Setting description

ARSi more effective in all the biomarker signatures

Simulations setting

Survival curves (by signature)


PFS distributions (by signature)


Treatment effects (by signature)

signature var Other ARSi Taxane_CT PARPi
all param scale = 0.024, shape = 1.3 scale = 0.014, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 66.5, median = 54.4 mean = 39, median = 31.9 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1.7, hr = 0.5 af = 1, hr = 1 af = 1, hr = 1
TP53- param scale = 0.024, shape = 1.3 scale = 0.014, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 66.5, median = 54.4 mean = 39, median = 31.9 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1.7, hr = 0.5 af = 1, hr = 1 af = 1, hr = 1
TP53+ param scale = 0.024, shape = 1.3 scale = 0.014, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 66.5, median = 54.4 mean = 39, median = 31.9 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1.7, hr = 0.5 af = 1, hr = 1 af = 1, hr = 1
HRD+ param scale = 0.024, shape = 1.3 scale = 0.014, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 66.5, median = 54.4 mean = 39, median = 31.9 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1.7, hr = 0.5 af = 1, hr = 1 af = 1, hr = 1
TEfus+ param scale = 0.024, shape = 1.3 scale = 0.014, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 66.5, median = 54.4 mean = 39, median = 31.9 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1.7, hr = 0.5 af = 1, hr = 1 af = 1, hr = 1



Survival curves (by subgroup)


PFS distributions (by subgroup)


Treatment effects (by subgroup)

subtype var Other ARSi Taxane_CT PARPi
— param scale = 0.024, shape = 1.3 scale = 0.014, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 66.5, median = 54.4 mean = 39, median = 31.9 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1.7, hr = 0.5 af = 1, hr = 1 af = 1, hr = 1
–+ param scale = 0.024, shape = 1.3 scale = 0.014, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 66.5, median = 54.4 mean = 39, median = 31.9 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1.7, hr = 0.5 af = 1, hr = 1 af = 1, hr = 1
-+- param scale = 0.024, shape = 1.3 scale = 0.014, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 66.5, median = 54.4 mean = 39, median = 31.9 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1.7, hr = 0.5 af = 1, hr = 1 af = 1, hr = 1
-++ param scale = 0.024, shape = 1.3 scale = 0.014, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 66.5, median = 54.4 mean = 39, median = 31.9 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1.7, hr = 0.5 af = 1, hr = 1 af = 1, hr = 1
+– param scale = 0.024, shape = 1.3 scale = 0.014, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 66.5, median = 54.4 mean = 39, median = 31.9 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1.7, hr = 0.5 af = 1, hr = 1 af = 1, hr = 1
+-+ param scale = 0.024, shape = 1.3 scale = 0.014, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 66.5, median = 54.4 mean = 39, median = 31.9 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1.7, hr = 0.5 af = 1, hr = 1 af = 1, hr = 1
++- param scale = 0.024, shape = 1.3 scale = 0.014, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 66.5, median = 54.4 mean = 39, median = 31.9 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1.7, hr = 0.5 af = 1, hr = 1 af = 1, hr = 1
+++ param scale = 0.024, shape = 1.3 scale = 0.014, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 66.5, median = 54.4 mean = 39, median = 31.9 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1.7, hr = 0.5 af = 1, hr = 1 af = 1, hr = 1

Errors and power


graduation (counts and proportions):
ARSi Taxane_CT PARPi
all 393 0 0
TP53- 335 0 0
TP53+ 338 2 1
HRD+ 193 1 0
TEfus+ 310 0 0
ARSi Taxane_CT PARPi
all 0.786 0.000 0.000
TP53- 0.670 0.000 0.000
TP53+ 0.676 0.004 0.002
HRD+ 0.386 0.002 0.000
TEfus+ 0.620 0.000 0.000
futility (counts and proportions):
ARSi Taxane_CT PARPi
all 0 211 252
TP53- 2 362 386
TP53+ 3 327 356
HRD+ 0 184 311
TEfus+ 3 307 339
ARSi Taxane_CT PARPi
all 0.000 0.422 0.504
TP53- 0.004 0.724 0.772
TP53+ 0.006 0.654 0.712
HRD+ 0.000 0.368 0.622
TEfus+ 0.006 0.614 0.678
max sample size (counts and proportions):
ARSi Taxane_CT PARPi
all 0 0 0
TP53- 59 29 23
TP53+ 10 17 6
HRD+ 0 0 0
TEfus+ 0 0 0
ARSi Taxane_CT PARPi
all 0.000 0.000 0.000
TP53- 0.118 0.058 0.046
TP53+ 0.020 0.034 0.012
HRD+ 0.000 0.000 0.000
TEfus+ 0.000 0.000 0.000


Errors & power

The overall error was 0.17.
The corresponding errors separate for the different treatments were:

     ARSi Taxane_CT     PARPi 
    0.166     0.006     0.002

The overall power was 0.786.
The corresponding power separate for the different treatments were:

     ARSi Taxane_CT     PARPi 
    0.786     0.000     0.000

Median results at the end of the trial

By signature:
signature var Control ARSi Taxane_CT PARPi
all graduation 0 393 0 0
futility 0 0 211 252
max_n 0 0 0 0
n 616 (456, 735) 325 (187, 517) 255 (133, 442) 232 (131, 409)
n_unique 616 (456, 735) 325 (187, 517) 255 (133, 442) 232 (131, 409)
time_trial 60 (60, 60) 40 (24, 60) 60 (31, 60) 60 (27, 60)
time_stop NA (NA, NA) 35 (23, 53) 41 (18, 57) 39 (23, 56)
post_p NA (NA, NA) 1 (1, 1) 0.02 (0, 0.18) 0.02 (0, 0.19)
rate 0.017 (0.016, 0.019) 0.011 (0.01, 0.012) 0.022 (0.02, 0.025) 0.022 (0.019, 0.025)
TP53- graduation 0 335 0 0
futility 0 2 362 386
max_n 0 59 29 23
n 344 (214, 413) 176 (100, 301) 117 (52, 283) 112 (54, 270)
n_unique 344 (214, 413) 176 (100, 301) 117 (52, 283) 112 (54, 270)
time_trial 60 (60, 60) 46 (27, 60) 42 (20, 60) 37 (18, 60)
time_stop NA (NA, NA) 37 (26, 55) 34 (18, 54) 30 (17, 52)
post_p NA (NA, NA) 1 (0.98, 1) 0.07 (0, 0.34) 0.06 (0, 0.37)
rate 0.017 (0.016, 0.019) 0.011 (0.01, 0.013) 0.022 (0.019, 0.027) 0.022 (0.019, 0.027)
TP53+ graduation 0 338 2 1
futility 0 3 327 356
max_n 0 10 17 6
n 292 (179, 351) 128 (75, 245) 108 (53, 238) 94 (52, 223)
n_unique 292 (179, 351) 128 (75, 245) 108 (53, 238) 94 (52, 223)
time_trial 60 (60, 60) 48 (29, 60) 44 (20, 60) 40 (21, 60)
time_stop NA (NA, NA) 40 (26, 55) 33 (18, 53) 32 (20, 52)
post_p NA (NA, NA) 1 (0.96, 1) 0.07 (0, 0.42) 0.09 (0, 0.38)
rate 0.017 (0.015, 0.019) 0.011 (0.009, 0.013) 0.022 (0.019, 0.027) 0.022 (0.019, 0.027)
HRD+ graduation 0 193 1 0
futility 0 0 184 311
max_n 0 0 0 0
n 160 (106, 206) 72 (41, 121) 74 (34, 134) 65 (48, 130)
n_unique 160 (106, 206) 72 (41, 121) 74 (34, 134) 65 (48, 130)
time_trial 60 (60, 60) 60 (36, 60) 60 (39, 60) 46 (21, 60)
time_stop NA (NA, NA) 43 (31, 57) 46 (34, 57) 30 (20, 54)
post_p NA (NA, NA) 0.98 (0.86, 1) 0.14 (0.01, 0.52) 0.12 (0.01, 0.51)
rate 0.017 (0.015, 0.02) 0.011 (0.009, 0.014) 0.021 (0.018, 0.028) 0.023 (0.019, 0.028)
TEfus+ graduation 0 310 0 0
futility 0 3 307 339
max_n 0 0 0 0
n 213 (139, 271) 99 (60, 178) 86 (50, 178) 79 (50, 160)
n_unique 213 (139, 271) 99 (60, 178) 86 (50, 178) 79 (50, 160)
time_trial 60 (60, 60) 52 (31, 60) 49 (24, 60) 44 (23, 60)
time_stop NA (NA, NA) 41 (29, 57) 35 (23, 53) 34 (21, 53)
post_p NA (NA, NA) 0.99 (0.91, 1) 0.1 (0, 0.43) 0.09 (0.01, 0.43)
rate 0.017 (0.015, 0.02) 0.011 (0.009, 0.013) 0.022 (0.019, 0.027) 0.022 (0.019, 0.028)


By subgroup combinations:
subtype var Control ARSi Taxane_CT PARPi
— graduation 0 433 387 397
futility 0 0 0 0
max_n 0 47 29 23
n 199 (122, 243) 108 (59, 194) 54 (22, 159) 52 (19, 156)
n_unique 199 (122, 243) 108 (59, 194) 54 (22, 159) 52 (19, 156)
post_p NA (NA, NA) 0.99 (0.89, 1) 0.15 (0.01, 0.53) 0.15 (0.02, 0.53)
rate 0.017 (0.015, 0.02) 0.011 (0.009, 0.014) 0.022 (0.018, 0.029) 0.022 (0.018, 0.029)
–+ graduation 0 451 422 433
futility 0 0 0 0
max_n 0 41 28 22
n 50 (27, 68) 24 (12, 47) 18 (10, 53) 16 (7, 48)
n_unique 50 (27, 68) 24 (12, 47) 18 (10, 53) 16 (7, 48)
post_p NA (NA, NA) 0.88 (0.59, 0.99) 0.23 (0.04, 0.66) 0.25 (0.05, 0.65)
rate 0.017 (0.013, 0.022) 0.011 (0.007, 0.016) 0.023 (0.016, 0.035) 0.023 (0.016, 0.036)
-+- graduation 0 439 351 382
futility 0 0 0 0
max_n 0 6 17 6
n 132 (78, 159) 60 (30, 122) 40 (20, 116) 37 (15, 111)
n_unique 132 (78, 159) 60 (30, 122) 40 (20, 116) 37 (15, 111)
post_p NA (NA, NA) 0.96 (0.77, 1) 0.17 (0.02, 0.57) 0.21 (0.02, 0.6)
rate 0.017 (0.014, 0.02) 0.011 (0.008, 0.014) 0.022 (0.018, 0.029) 0.022 (0.017, 0.03)
-++ graduation 0 455 421 435
futility 0 0 0 0
max_n 0 6 17 5
n 86 (48, 113) 39 (21, 80) 27 (16, 79) 24 (11, 75)
n_unique 86 (48, 113) 39 (21, 80) 27 (16, 79) 24 (11, 75)
post_p NA (NA, NA) 0.94 (0.66, 1) 0.21 (0.03, 0.59) 0.23 (0.04, 0.61)
rate 0.017 (0.014, 0.021) 0.011 (0.008, 0.015) 0.022 (0.017, 0.03) 0.023 (0.016, 0.032)
+– graduation 0 440 415 441
futility 0 0 0 0
max_n 0 47 28 22
n 46 (27, 63) 20 (9, 38) 20 (6, 46) 17 (10, 43)
n_unique 46 (27, 63) 20 (9, 38) 20 (6, 46) 17 (10, 43)
post_p NA (NA, NA) 0.86 (0.5, 0.98) 0.28 (0.07, 0.62) 0.25 (0.05, 0.65)
rate 0.017 (0.013, 0.022) 0.011 (0.006, 0.017) 0.023 (0.015, 0.034) 0.023 (0.016, 0.034)
+-+ graduation 0 457 438 458
futility 0 0 0 0
max_n 0 41 28 21
n 43 (24, 63) 19 (9, 38) 14 (5, 44) 16 (9, 42)
n_unique 43 (24, 63) 19 (9, 38) 14 (5, 44) 16 (9, 42)
post_p NA (NA, NA) 0.86 (0.54, 0.98) 0.3 (0.06, 0.66) 0.26 (0.05, 0.66)
rate 0.018 (0.013, 0.023) 0.011 (0.006, 0.017) 0.023 (0.015, 0.038) 0.023 (0.016, 0.034)
++- graduation 0 444 374 423
futility 0 0 0 0
max_n 0 6 17 5
n 37 (19, 51) 14 (7, 32) 15 (5, 39) 14 (8, 36)
n_unique 37 (19, 51) 14 (7, 32) 15 (5, 39) 14 (8, 36)
post_p NA (NA, NA) 0.81 (0.48, 0.97) 0.34 (0.08, 0.71) 0.3 (0.06, 0.67)
rate 0.018 (0.013, 0.024) 0.011 (0.006, 0.018) 0.022 (0.013, 0.037) 0.023 (0.016, 0.036)
+++ graduation 0 459 428 453
futility 0 0 0 0
max_n 0 6 17 5
n 33 (19, 50) 14 (7, 28) 13 (4, 36) 13 (8, 33)
n_unique 33 (19, 50) 14 (7, 28) 13 (4, 36) 13 (8, 33)
post_p NA (NA, NA) 0.81 (0.46, 0.97) 0.32 (0.08, 0.69) 0.27 (0.06, 0.64)
rate 0.017 (0.012, 0.023) 0.011 (0.005, 0.018) 0.022 (0.014, 0.036) 0.023 (0.016, 0.037)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var ARSi Taxane_CT PARPi
all count 393
time_stop 35 (23, 53)
n_trt 289 (179, 464)
n_control 396 (240, 601)
post_p 1 (0.97, 1)
order 2 (1, 3)
TP53- count 335
time_stop 38 (26, 55)
n_trt 156 (98, 260)
n_control 230 (147, 341)
post_p 0.99 (0.95, 1)
order 2 (1, 4)
TP53+ count 338 2 1
time_stop 40 (27, 55) 39 (31, 47) 33 (33, 33)
n_trt 118 (76, 202) 106 (96, 115) 93 (93, 93)
n_control 193 (126, 284) 216 (181, 252) 174 (174, 174)
post_p 0.99 (0.95, 1) 0.95 (0.91, 0.98) 0.98 (0.98, 0.98)
order 2 (1, 4) 2 (2, 2) 1 (1, 1)
HRD+ count 193 1
time_stop 43 (31, 57) 41 (41, 41)
n_trt 73 (55, 115) 71 (71, 71)
n_control 125 (89, 172) 111 (111, 111)
post_p 0.99 (0.94, 1) 0.98 (0.98, 0.98)
order 3 (1, 5) 2 (2, 2)
TEfus+ count 310
time_stop 41 (29, 57)
n_trt 95 (62, 163)
n_control 162 (111, 233)
post_p 0.99 (0.95, 1)
order 3 (1, 5)
Futility:
signature var ARSi Taxane_CT PARPi
all count 211 252
time_stop 41 (18, 57) 39 (23, 56)
n_trt 183 (101, 315) 177 (115, 309)
n_control 439 (176, 608) 431 (233, 586)
post_p 0.02 (0, 0.12) 0.02 (0, 0.1)
order 5 (1, 8) 4 (2, 7)
TP53- count 2 362 386
time_stop 21 (14, 28) 34 (18, 54) 30 (17, 52)
n_trt 91 (63, 119) 95 (55, 220) 93 (54, 206)
n_control 125 (79, 171) 207 (98, 353) 177 (92, 327)
post_p 0.28 (0.26, 0.29) 0.1 (0.01, 0.24) 0.11 (0.02, 0.26)
order 1.5 (1.1, 1.9) 3 (1, 6) 3 (1, 7)
TP53+ count 3 327 356
time_stop 22 (20, 29) 33 (18, 53) 32 (20, 52)
n_trt 53 (52, 91) 83 (53, 175) 80 (53, 166)
n_control 114 (95, 142) 167 (82, 286) 154 (92, 270)
post_p 0.23 (0.18, 0.29) 0.1 (0.02, 0.24) 0.12 (0.02, 0.25)
order 1 (1, 1.8) 3 (1, 7) 3 (1, 7)
HRD+ count 184 311
time_stop 46 (34, 57) 30 (20, 54)
n_trt 71 (52, 107) 60 (50, 105)
n_control 130 (98, 175) 91 (54, 162)
post_p 0.09 (0.01, 0.24) 0.13 (0.03, 0.27)
order 6 (3, 9) 3 (1, 7)
TEfus+ count 3 307 339
time_stop 29 (21, 38) 35 (23, 53) 34 (21, 53)
n_trt 60 (52, 63) 72 (52, 129) 69 (51, 129)
n_control 95 (95, 145) 143 (85, 221) 132 (77, 214)
post_p 0.19 (0.04, 0.22) 0.1 (0.02, 0.23) 0.12 (0.02, 0.26)
order 3 (2.2, 3) 4 (2, 8) 4 (1, 7)


By subgroup combinations

Graduation:
signature treatment var — –+ -+- -++ +– +-+ ++- +++
all ARSi count 393 393 393 393 393 393 393 393
time 35 (23, 53) 35 (23, 53) 35 (23, 53) 35 (23, 53) 35 (23, 53) 35 (23, 53) 35 (23, 53) 35 (23, 53)
n 98 (57, 173) 23 (12, 43) 54 (29, 101) 36 (20, 71) 19 (9, 34) 18 (9, 34) 13 (7, 26) 13 (7, 25)
post_p 0.92 (0.65, 1) 0.72 (0.58, 0.94) 0.86 (0.6, 0.99) 0.81 (0.58, 0.97) 0.69 (0.57, 0.94) 0.73 (0.57, 0.93) 0.66 (0.56, 0.9) 0.66 (0.56, 0.89)
r_prob 0.37 (0.37, 0.37) 0.19 (0.19, 0.19) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.01 (0.006, 0.013) 0.009 (0, 0.014) 0.009 (0.005, 0.014) 0.009 (0.004, 0.014) 0.009 (0, 0.015) 0.008 (0, 0.015) 0.008 (0, 0.015) 0.008 (0, 0.015)
TP53- count 335 335 335 335
time 38 (26, 55) 38 (26, 55) 38 (26, 55) 38 (26, 55)
n 96 (58, 163) 23 (12, 41) 18 (9, 34) 18 (8, 33)
post_p 0.93 (0.74, 1) 0.78 (0.7, 0.94) 0.76 (0.66, 0.93) 0.78 (0.65, 0.96)
r_prob 0.37 (0.37, 0.37) 0.19 (0.19, 0.19) 0 (0, 0) 0 (0, 0)
rate 0.01 (0.007, 0.013) 0.008 (0.002, 0.013) 0.008 (0, 0.013) 0.008 (0, 0.013)
TP53+ count 338 338 338 338
time 40 (27, 55) 40 (27, 55) 40 (27, 55) 40 (27, 55)
n 54 (30, 96) 37 (21, 69) 13 (7, 26) 13 (7, 25)
post_p 0.88 (0.72, 0.99) 0.84 (0.72, 0.98) 0.74 (0.62, 0.92) 0.74 (0.61, 0.91)
r_prob 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.01 (0.005, 0.013) 0.009 (0.004, 0.013) 0.008 (0, 0.013) 0.007 (0, 0.013)
Taxane_CT count 2 2 2 2
time 39 (31, 47) 39 (31, 47) 39 (31, 47) 39 (31, 47)
n 54 (49, 58) 22 (22, 22) 13 (11, 15) 17 (10, 24)
post_p 0.9 (0.88, 0.91) 0.73 (0.72, 0.73) 0.7 (0.63, 0.77) 0.66 (0.61, 0.7)
r_prob 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0)
rate 0.013 (0.01, 0.016) 0.014 (0.011, 0.016) 0.008 (0.006, 0.011) 0.011 (0.011, 0.011)
PARPi count 1 1 1 1
time 33 (33, 33) 33 (33, 33) 33 (33, 33) 33 (33, 33)
n 42 (42, 42) 16 (16, 16) 16 (16, 16) 19 (19, 19)
post_p 0.73 (0.73, 0.73) 0.7 (0.7, 0.7) 0.77 (0.77, 0.77) 0.71 (0.71, 0.71)
r_prob 0 (0, 0) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5)
rate 0.011 (0.011, 0.011) 0.014 (0.014, 0.014) 0.003 (0.003, 0.003) 0.004 (0.004, 0.004)
HRD+ ARSi count 193 193 193 193
time 43 (31, 57) 43 (31, 57) 43 (31, 57) 43 (31, 57)
n 22 (11, 37) 21 (13, 36) 15 (8, 27) 14 (8, 26)
post_p 0.81 (0.71, 0.97) 0.81 (0.71, 0.97) 0.76 (0.65, 0.92) 0.75 (0.65, 0.93)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.009 (0.004, 0.013) 0.008 (0.003, 0.014) 0.008 (0, 0.014) 0.008 (0, 0.014)
Taxane_CT count 1 1 1 1
time 41 (41, 41) 41 (41, 41) 41 (41, 41) 41 (41, 41)
n 37 (37, 37) 23 (23, 23) 7 (7, 7) 4 (4, 4)
post_p 0.73 (0.73, 0.73) 0.93 (0.93, 0.93) 0.6 (0.6, 0.6) 0.62 (0.62, 0.62)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.009 (0.009, 0.009) 0.009 (0.009, 0.009) 0.012 (0.012, 0.012) 0.011 (0.011, 0.011)
TEfus+ ARSi count 310 310 310 310
time 41 (29, 57) 41 (29, 57) 41 (29, 57) 41 (29, 57)
n 24 (14, 44) 37 (22, 71) 20 (9, 36) 14 (7, 25)
post_p 0.79 (0.71, 0.95) 0.88 (0.72, 0.99) 0.79 (0.7, 0.97) 0.74 (0.63, 0.92)
r_prob 0.19 (0.19, 0.19) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.009 (0.004, 0.013) 0.009 (0.005, 0.013) 0.008 (0, 0.014) 0.007 (0, 0.013)
Futility:
signature treatment var — –+ -+- -++ +– +-+ ++- +++
all Taxane_CT count 211 211 211 211 211 211 211 211
time 41 (18, 57) 41 (18, 57) 41 (18, 57) 41 (18, 57) 41 (18, 57) 41 (18, 57) 41 (18, 57) 41 (18, 57)
n 41 (21, 122) 16 (8, 35) 31 (18, 84) 23 (14, 49) 13 (4, 37) 11 (5, 31) 9 (3, 25) 9 (3, 23)
post_p 0.25 (0.03, 0.46) 0.3 (0.07, 0.46) 0.21 (0.02, 0.45) 0.26 (0.05, 0.46) 0.35 (0.11, 0.49) 0.36 (0.1, 0.48) 0.39 (0.12, 0.48) 0.38 (0.11, 0.48)
r_prob 0.25 (0.25, 0.25) 0.38 (0.38, 0.38) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.02 (0.016, 0.029) 0.023 (0.016, 0.036) 0.022 (0.016, 0.029) 0.022 (0.015, 0.03) 0.022 (0.015, 0.038) 0.023 (0.014, 0.044) 0.023 (0.013, 0.044) 0.023 (0.014, 0.038)
PARPi count 252 252 252 252 252 252 252 252
time 39 (23, 56) 39 (23, 56) 39 (23, 56) 39 (23, 56) 39 (23, 56) 39 (23, 56) 39 (23, 56) 39 (23, 56)
n 38 (17, 107) 13 (6, 37) 30 (14, 77) 20 (10, 51) 15 (10, 29) 15 (9, 27) 12 (8, 24) 12 (7, 20)
post_p 0.23 (0.04, 0.46) 0.35 (0.1, 0.47) 0.29 (0.06, 0.47) 0.32 (0.06, 0.48) 0.27 (0.07, 0.47) 0.3 (0.09, 0.46) 0.32 (0.11, 0.47) 0.34 (0.09, 0.47)
r_prob 0 (0, 0) 0.06 (0.06, 0.06) 0 (0, 0) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5)
rate 0.02 (0.015, 0.029) 0.023 (0.015, 0.041) 0.021 (0.016, 0.03) 0.022 (0.015, 0.033) 0.023 (0.014, 0.035) 0.023 (0.016, 0.035) 0.023 (0.013, 0.036) 0.023 (0.013, 0.037)
TP53- ARSi count 2 2 2 2
time 21 (14, 28) 21 (14, 28) 21 (14, 28) 21 (14, 28)
n 66 (43, 88) 12 (8, 15) 8 (8, 8) 6 (4, 8)
post_p 0.39 (0.33, 0.45) 0.48 (0.47, 0.5) 0.43 (0.42, 0.44) 0.43 (0.4, 0.47)
r_prob 0.37 (0.37, 0.37) 0.19 (0.19, 0.19) 0 (0, 0) 0 (0, 0)
rate 0.014 (0.012, 0.016) 0.008 (0.002, 0.014) 0.03 (0.025, 0.035) 0.01 (0.002, 0.018)
Taxane_CT count 362 362 362 362
time 34 (18, 54) 34 (18, 54) 34 (18, 54) 34 (18, 54)
n 44 (24, 128) 17 (10, 41) 15 (6, 39) 13 (6, 36)
post_p 0.25 (0.04, 0.46) 0.33 (0.1, 0.47) 0.41 (0.16, 0.49) 0.41 (0.16, 0.49)
r_prob 0.25 (0.25, 0.25) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0)
rate 0.02 (0.015, 0.027) 0.021 (0.014, 0.034) 0.022 (0.015, 0.04) 0.022 (0.014, 0.037)
PARPi count 386 386 386 386
time 30 (17, 52) 30 (17, 52) 30 (17, 52) 30 (17, 52)
n 39 (18, 126) 14 (7, 40) 16 (10, 35) 15 (9, 30)
post_p 0.31 (0.06, 0.47) 0.41 (0.14, 0.49) 0.36 (0.12, 0.48) 0.36 (0.16, 0.48)
r_prob 0 (0, 0) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5)
rate 0.019 (0.014, 0.027) 0.021 (0.013, 0.042) 0.021 (0.013, 0.035) 0.02 (0.013, 0.034)
TP53+ ARSi count 3 3 3 3
time 22 (20, 29) 22 (20, 29) 22 (20, 29) 22 (20, 29)
n 27 (18, 42) 22 (19, 24) 4 (3, 6) 12 (5, 22)
post_p 0.47 (0.41, 0.48) 0.44 (0.38, 0.49) 0.37 (0.28, 0.4) 0.47 (0.46, 0.48)
r_prob 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.012 (0.011, 0.02) 0.022 (0.019, 0.022) 0.081 (0.037, 0.128) 0.017 (0.012, 0.028)
Taxane_CT count 327 327 327 327
time 33 (18, 53) 33 (18, 53) 33 (18, 53) 33 (18, 53)
n 32 (20, 83) 24 (16, 59) 11 (5, 27) 10 (4, 25)
post_p 0.27 (0.05, 0.46) 0.3 (0.09, 0.46) 0.43 (0.19, 0.49) 0.43 (0.25, 0.49)
r_prob 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0)
rate 0.02 (0.014, 0.029) 0.02 (0.014, 0.029) 0.023 (0.014, 0.046) 0.022 (0.013, 0.042)
PARPi count 356 356 356 356
time 32 (20, 52) 32 (20, 52) 32 (20, 52) 32 (20, 52)
n 31 (15, 77) 21 (11, 57) 13 (8, 26) 12 (8, 22)
post_p 0.34 (0.09, 0.48) 0.37 (0.11, 0.48) 0.36 (0.15, 0.48) 0.38 (0.12, 0.48)
r_prob 0 (0, 0) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5)
rate 0.02 (0.014, 0.029) 0.02 (0.014, 0.032) 0.022 (0.013, 0.036) 0.021 (0.012, 0.036)
HRD+ Taxane_CT count 184 184 184 184
time 46 (34, 57) 46 (34, 57) 46 (34, 57) 46 (34, 57)
n 22 (8, 41) 18 (7, 41) 14 (5, 29) 13 (5, 28)
post_p 0.32 (0.11, 0.49) 0.3 (0.08, 0.47) 0.35 (0.13, 0.47) 0.36 (0.11, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.021 (0.015, 0.034) 0.023 (0.015, 0.037) 0.023 (0.016, 0.04) 0.023 (0.015, 0.04)
PARPi count 311 311 311 311
time 30 (20, 54) 30 (20, 54) 30 (20, 54) 30 (20, 54)
n 17 (11, 35) 16 (10, 33) 14 (8, 28) 13 (8, 24)
post_p 0.36 (0.11, 0.48) 0.36 (0.13, 0.48) 0.4 (0.18, 0.48) 0.38 (0.14, 0.48)
r_prob 0.5 (0.5, 0.5) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5)
rate 0.021 (0.012, 0.034) 0.02 (0.014, 0.031) 0.021 (0.012, 0.034) 0.022 (0.012, 0.036)
TEfus+ ARSi count 3 3 3 3
time 29 (21, 38) 29 (21, 38) 29 (21, 38) 29 (21, 38)
n 9 (9, 11) 21 (15, 33) 12 (10, 14) 10 (6, 20)
post_p 0.39 (0.2, 0.43) 0.5 (0.13, 0.5) 0.31 (0.13, 0.44) 0.45 (0.45, 0.49)
r_prob 0.19 (0.19, 0.19) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.025 (0.022, 0.025) 0.013 (0.011, 0.024) 0.024 (0.022, 0.027) 0.02 (0.016, 0.034)
Taxane_CT count 307 307 307 307
time 35 (23, 53) 35 (23, 53) 35 (23, 53) 35 (23, 53)
n 18 (11, 38) 25 (16, 58) 13 (6, 34) 12 (5, 26)
post_p 0.31 (0.09, 0.48) 0.28 (0.07, 0.46) 0.4 (0.13, 0.48) 0.41 (0.2, 0.49)
r_prob 0.38 (0.38, 0.38) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0)
rate 0.022 (0.014, 0.033) 0.02 (0.014, 0.028) 0.022 (0.014, 0.037) 0.022 (0.014, 0.041)
PARPi count 339 339 339 339
time 34 (21, 53) 34 (21, 53) 34 (21, 53) 34 (21, 53)
n 15 (7, 39) 23 (12, 58) 16 (10, 30) 12 (8, 22)
post_p 0.39 (0.14, 0.49) 0.38 (0.11, 0.48) 0.33 (0.1, 0.47) 0.36 (0.11, 0.48)
r_prob 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5)
rate 0.021 (0.014, 0.04) 0.019 (0.014, 0.03) 0.022 (0.014, 0.034) 0.022 (0.013, 0.036)