Simulation scenario 8, CR phase

Setting description

Taxane_CT less effective in the TP53+ biomarker signature

Simulations setting

Survival curves (by signature)

PFS distributions (by signature)

Treatment effects (by signature)

signature	var	Other	ARSi	Taxane_CT	Platinum_CT	PARPi
all	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.159, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 6.2, median = 4.4	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 0.7, hr = 1.45	af = 1, hr = 1	af = 1, hr = 1
TP53- & AR-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
TP53+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 1, hr = 1	af = 1, hr = 1
HRD+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 1, hr = 1	af = 1, hr = 1
TEfus+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.168, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 5.8, median = 4.2	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 0.66, hr = 1.54	af = 1, hr = 1	af = 1, hr = 1

Survival curves (by subgroup)

PFS distributions (by subgroup)

Treatment effects (by subgroup)

subtype	var	Other	ARSi	Taxane_CT	Platinum_CT	PARPi
—-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 1, hr = 1	af = 1, hr = 1
–++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 1, hr = 1	af = 1, hr = 1
-+–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 1, hr = 1	af = 1, hr = 1
-+++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 1, hr = 1	af = 1, hr = 1
+—	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+–+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 1, hr = 1	af = 1, hr = 1
+-++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 1, hr = 1	af = 1, hr = 1
++–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 1, hr = 1	af = 1, hr = 1
++++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 1, hr = 1	af = 1, hr = 1

Errors and power

graduation (counts and proportions):

ARSi Taxane_CT Platinum_CT PARPi all 18 0 1 3 TP53- & AR- 55 39 27 26 TP53+ 50 0 19 9 HRD+ 4 0 2 4 TEfus+ 5 1 9 9

ARSi Taxane_CT Platinum_CT PARPi all 0.036 0.000 0.002 0.006 TP53- & AR- 0.110 0.078 0.054 0.052 TP53+ 0.100 0.000 0.038 0.018 HRD+ 0.008 0.000 0.004 0.008 TEfus+ 0.010 0.002 0.018 0.018

futility (counts and proportions):

ARSi Taxane_CT Platinum_CT PARPi all 1 23 0 0 TP53- & AR- 148 124 115 120 TP53+ 3 396 0 4 HRD+ 13 63 14 13 TEfus+ 3 119 7 4

ARSi Taxane_CT Platinum_CT PARPi all 0.002 0.046 0.000 0.000 TP53- & AR- 0.296 0.248 0.230 0.240 TP53+ 0.006 0.792 0.000 0.008 HRD+ 0.026 0.126 0.028 0.026 TEfus+ 0.006 0.238 0.014 0.008

max sample size (counts and proportions):

ARSi Taxane_CT Platinum_CT PARPi all 0 0 0 0 TP53- & AR- 19 9 23 16 TP53+ 25 0 36 27 HRD+ 0 0 0 0 TEfus+ 0 0 1 0

ARSi Taxane_CT Platinum_CT PARPi all 0.000 0.000 0.000 0.000 TP53- & AR- 0.038 0.018 0.046 0.032 TP53+ 0.050 0.000 0.072 0.054 HRD+ 0.000 0.000 0.000 0.000 TEfus+ 0.000 0.000 0.002 0.000

Errors & power

The overall error was 0.414.
The corresponding errors separate for the different treatments were:

       ARSi   Taxane_CT Platinum_CT       PARPi 
      0.242       0.078       0.098       0.096 

The overall power was .
The corresponding power separate for the different treatments were:

NULL

Median results at the end of the trial

By signature:

signature	var	Control	ARSi	Taxane_CT	Platinum_CT	PARPi
all	graduation	0	18	0	1	3
	futility	0	1	23	0	0
	max_n	0	0	0	0	0
	n	422 (388, 456)	200 (132, 271)	138 (91, 196)	206 (150, 275)	206 (152, 269)
	n_unique	383 (350, 414)	182 (120, 250)	126 (81, 179)	188 (135, 253)	189 (137, 250)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	5 (4, 9)	20 (5, 32)	6 (6, 6)	7 (7, 8)
	post_p	NA (NA, NA)	0.8 (0.35, 0.98)	0.19 (0.01, 0.74)	0.82 (0.36, 0.99)	0.82 (0.36, 0.98)
	rate	0.122 (0.114, 0.131)	0.113 (0.103, 0.125)	0.134 (0.117, 0.158)	0.112 (0.102, 0.124)	0.112 (0.102, 0.126)
TP53- & AR-	graduation	0	55	39	27	26
	futility	0	148	124	115	120
	max_n	0	19	9	23	16
	n	175 (148, 200)	68 (27, 127)	70 (27, 122)	68 (29, 133)	68 (31, 129)
	n_unique	160 (136, 183)	61 (25, 120)	64 (25, 114)	62 (26, 125)	63 (28, 120)
	time_trial	36 (36, 36)	36 (9, 36)	36 (15, 36)	36 (17, 36)	36 (17, 36)
	time_stop	NA (NA, NA)	15 (7, 30)	18 (11, 32)	19 (11, 33)	20 (12, 34)
	post_p	NA (NA, NA)	0.45 (0.09, 0.88)	0.45 (0.09, 0.88)	0.45 (0.1, 0.83)	0.44 (0.1, 0.88)
	rate	0.111 (0.1, 0.124)	0.114 (0.096, 0.143)	0.114 (0.096, 0.145)	0.114 (0.098, 0.14)	0.114 (0.095, 0.14)
TP53+	graduation	0	50	0	19	9
	futility	0	3	396	0	4
	max_n	0	25	0	36	27
	n	187 (167, 214)	100 (34, 141)	35 (25, 54)	107 (73, 142)	106 (71, 140)
	n_unique	169 (151, 193)	92 (30, 130)	32 (23, 50)	97 (66, 131)	96 (62, 129)
	time_trial	36 (36, 36)	36 (20, 36)	20 (11, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	10 (8, 16)	17 (10, 30)	15 (9, 30)	14 (8, 22)
	post_p	NA (NA, NA)	0.92 (0.54, 1)	0.01 (0, 0.06)	0.94 (0.61, 1)	0.93 (0.52, 1)
	rate	0.138 (0.125, 0.152)	0.112 (0.098, 0.132)	0.224 (0.188, 0.284)	0.111 (0.099, 0.129)	0.113 (0.098, 0.132)
HRD+	graduation	0	4	0	2	4
	futility	0	13	63	14	13
	max_n	0	0	0	0	0
	n	113 (96, 130)	50 (27, 73)	39 (23, 58)	66 (48, 87)	66 (47, 85)
	n_unique	101 (85, 116)	44 (24, 65)	34 (20, 51)	59 (42, 80)	60 (42, 78)
	time_trial	36 (36, 36)	36 (36, 36)	36 (34, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	25 (18, 33)	29 (22, 35)	16 (10, 32)	17 (11, 29)
	post_p	NA (NA, NA)	0.62 (0.16, 0.93)	0.29 (0.04, 0.76)	0.67 (0.22, 0.96)	0.67 (0.22, 0.94)
	rate	0.122 (0.107, 0.14)	0.115 (0.092, 0.148)	0.137 (0.107, 0.18)	0.113 (0.095, 0.136)	0.112 (0.096, 0.136)
TEfus+	graduation	0	5	1	9	9
	futility	0	3	119	7	4
	max_n	0	0	0	1	0
	n	153 (136, 173)	74 (42, 102)	52 (31, 72)	80 (55, 106)	82 (56, 109)
	n_unique	138 (121, 157)	67 (38, 93)	46 (28, 64)	73 (48, 97)	72 (50, 100)
	time_trial	36 (36, 36)	36 (36, 36)	36 (19, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	20 (13, 34)	20 (11, 32)	13 (11, 20)	17 (11, 26)
	post_p	NA (NA, NA)	0.73 (0.26, 0.97)	0.2 (0.02, 0.7)	0.75 (0.32, 0.97)	0.75 (0.31, 0.97)
	rate	0.125 (0.113, 0.142)	0.114 (0.096, 0.135)	0.146 (0.118, 0.189)	0.112 (0.096, 0.134)	0.112 (0.097, 0.133)

By subgroup combinations:

subtype	var	Control	ARSi	Taxane_CT	Platinum_CT	PARPi
—-	graduation	0	219	176	143	149
	futility	0	0	0	0	0
	max_n	0	19	9	23	16
	n	112 (90, 134)	34 (18, 96)	36 (12, 90)	36 (10, 91)	33 (12, 90)
	n_unique	102 (83, 124)	32 (16, 92)	34 (10, 86)	33 (9, 88)	30 (10, 87)
	post_p	NA (NA, NA)	0.44 (0.1, 0.88)	0.45 (0.11, 0.87)	0.41 (0.08, 0.83)	0.41 (0.1, 0.86)
	rate	0.112 (0.097, 0.127)	0.116 (0.096, 0.155)	0.115 (0.094, 0.167)	0.118 (0.095, 0.19)	0.118 (0.095, 0.176)
—+	graduation	0	221	233	149	160
	futility	0	0	0	0	0
	max_n	0	19	9	24	16
	n	21 (14, 28)	7 (3, 20)	8 (3, 19)	8 (2, 20)	9 (2, 19)
	n_unique	19 (13, 25)	7 (2, 18)	7 (3, 17)	7 (2, 18)	8 (2, 18)
	post_p	NA (NA, NA)	0.46 (0.18, 0.81)	0.45 (0.2, 0.82)	0.46 (0.2, 0.84)	0.48 (0.22, 0.84)
	rate	0.113 (0.083, 0.153)	0.125 (0.078, 0.27)	0.124 (0.076, 0.245)	0.123 (0.075, 0.268)	0.118 (0.075, 0.272)
–+-	graduation	0	69	404	20	16
	futility	0	0	0	0	0
	max_n	0	25	0	36	27
	n	62 (51, 76)	34 (12, 62)	7 (4, 15)	33 (11, 59)	33 (10, 59)
	n_unique	57 (45, 70)	31 (11, 58)	7 (4, 13)	30 (9, 55)	30 (9, 55)
	post_p	NA (NA, NA)	0.78 (0.25, 0.98)	0.16 (0.05, 0.35)	0.79 (0.2, 0.98)	0.76 (0.24, 0.99)
	rate	0.14 (0.116, 0.17)	0.116 (0.093, 0.173)	0.242 (0.172, 0.458)	0.114 (0.091, 0.183)	0.117 (0.089, 0.178)
–++	graduation	0	75	416	35	28
	futility	0	0	0	0	0
	max_n	0	25	0	36	27
	n	43 (34, 53)	21 (5, 41)	8 (5, 14)	20 (6, 39)	21 (6, 39)
	n_unique	39 (30, 48)	18 (5, 37)	8 (4, 13)	18 (5, 36)	19 (5, 36)
	post_p	NA (NA, NA)	0.7 (0.24, 0.97)	0.16 (0.04, 0.38)	0.74 (0.24, 0.97)	0.72 (0.22, 0.97)
	rate	0.139 (0.114, 0.178)	0.116 (0.085, 0.195)	0.237 (0.165, 0.414)	0.115 (0.084, 0.198)	0.117 (0.086, 0.219)
-+–	graduation	0	229	214	155	164
	futility	0	0	0	0	0
	max_n	0	19	9	23	16
	n	21 (14, 28)	6 (1, 18)	7 (2, 18)	9 (3, 22)	10 (4, 21)
	n_unique	18 (12, 25)	5 (1, 16)	6 (2, 16)	8 (3, 20)	9 (3, 20)
	post_p	NA (NA, NA)	0.45 (0.18, 0.81)	0.46 (0.18, 0.8)	0.45 (0.16, 0.81)	0.46 (0.17, 0.85)
	rate	0.113 (0.082, 0.156)	0.126 (0.073, 0.326)	0.126 (0.077, 0.305)	0.127 (0.08, 0.26)	0.122 (0.08, 0.241)
-+-+	graduation	0	231	258	161	175
	futility	0	0	0	0	0
	max_n	0	19	9	24	16
	n	21 (15, 28)	6 (1, 18)	6 (2, 19)	9 (4, 20)	10 (4, 21)
	n_unique	19 (13, 26)	5 (1, 16)	5 (2, 17)	8 (3, 18)	8 (3, 19)
	post_p	NA (NA, NA)	0.47 (0.2, 0.84)	0.43 (0.2, 0.8)	0.46 (0.18, 0.81)	0.49 (0.19, 0.83)
	rate	0.114 (0.083, 0.162)	0.123 (0.076, 0.342)	0.127 (0.077, 0.322)	0.121 (0.08, 0.261)	0.12 (0.08, 0.235)
-++-	graduation	0	83	409	35	32
	futility	0	0	0	0	0
	max_n	0	25	0	36	27
	n	12 (8, 17)	5 (1, 12)	2 (0, 6)	7 (3, 13)	7 (3, 14)
	n_unique	11 (6, 16)	4 (1, 11)	2 (0, 5)	7 (2, 12)	6 (2, 13)
	post_p	NA (NA, NA)	0.53 (0.26, 0.86)	0.34 (0.18, 0.5)	0.56 (0.27, 0.86)	0.54 (0.27, 0.89)
	rate	0.141 (0.09, 0.228)	0.129 (0.068, 0.39)	0.269 (0.141, 1.114)	0.124 (0.073, 0.264)	0.122 (0.072, 0.261)
-+++	graduation	0	89	420	50	44
	futility	0	0	0	0	0
	max_n	0	25	0	36	27
	n	12 (7, 17)	5 (1, 11)	2 (0, 6)	7 (3, 14)	7 (3, 14)
	n_unique	10 (6, 15)	5 (1, 10)	2 (0, 5)	6 (2, 13)	6 (2, 13)
	post_p	NA (NA, NA)	0.54 (0.27, 0.86)	0.34 (0.19, 0.51)	0.56 (0.25, 0.88)	0.58 (0.26, 0.88)
	rate	0.139 (0.09, 0.228)	0.129 (0.07, 0.323)	0.275 (0.145, 0.897)	0.124 (0.073, 0.276)	0.118 (0.072, 0.293)
+—	graduation	0	19	23	1	3
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	20 (14, 27)	9 (3, 18)	10 (4, 20)	8 (3, 17)	8 (3, 17)
	n_unique	18 (12, 25)	8 (3, 17)	9 (4, 18)	7 (3, 16)	8 (3, 15)
	post_p	NA (NA, NA)	0.45 (0.17, 0.82)	0.46 (0.18, 0.83)	0.44 (0.19, 0.83)	0.48 (0.19, 0.84)
	rate	0.113 (0.083, 0.158)	0.124 (0.078, 0.279)	0.122 (0.081, 0.233)	0.123 (0.076, 0.261)	0.122 (0.075, 0.255)
+–+	graduation	0	27	129	17	16
	futility	0	0	0	0	0
	max_n	0	0	0	1	0
	n	16 (11, 22)	7 (3, 15)	8 (3, 16)	7 (2, 14)	6 (2, 14)
	n_unique	14 (9, 20)	6 (2, 13)	7 (3, 14)	6 (2, 13)	6 (2, 13)
	post_p	NA (NA, NA)	0.45 (0.2, 0.82)	0.46 (0.19, 0.81)	0.47 (0.2, 0.83)	0.46 (0.21, 0.83)
	rate	0.114 (0.082, 0.169)	0.127 (0.08, 0.31)	0.122 (0.08, 0.27)	0.122 (0.071, 0.318)	0.127 (0.069, 0.306)
+-+-	graduation	0	69	404	20	16
	futility	0	0	0	0	0
	max_n	0	25	0	36	27
	n	17 (11, 23)	7 (2, 17)	4 (2, 8)	9 (3, 18)	8 (3, 17)
	n_unique	15 (10, 22)	6 (2, 15)	4 (2, 7)	8 (2, 16)	7 (2, 16)
	post_p	NA (NA, NA)	0.59 (0.24, 0.91)	0.27 (0.12, 0.47)	0.61 (0.23, 0.93)	0.57 (0.25, 0.9)
	rate	0.14 (0.097, 0.205)	0.123 (0.074, 0.297)	0.244 (0.155, 0.581)	0.122 (0.073, 0.321)	0.123 (0.074, 0.288)
+-++	graduation	0	75	416	35	28
	futility	0	0	0	0	0
	max_n	0	25	0	36	27
	n	16 (11, 23)	7 (2, 17)	4 (2, 8)	8 (3, 16)	8 (3, 17)
	n_unique	15 (10, 20)	6 (1, 16)	4 (2, 7)	7 (2, 14)	7 (2, 15)
	post_p	NA (NA, NA)	0.6 (0.23, 0.9)	0.26 (0.11, 0.47)	0.59 (0.23, 0.92)	0.6 (0.26, 0.91)
	rate	0.139 (0.098, 0.201)	0.119 (0.071, 0.32)	0.257 (0.152, 0.561)	0.119 (0.071, 0.302)	0.12 (0.07, 0.284)
++–	graduation	0	36	77	17	20
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	11 (7, 16)	5 (2, 10)	5 (2, 11)	6 (2, 12)	6 (3, 12)
	n_unique	10 (6, 15)	4 (1, 9)	4 (1, 10)	5 (2, 11)	6 (2, 11)
	post_p	NA (NA, NA)	0.46 (0.23, 0.78)	0.48 (0.22, 0.81)	0.44 (0.2, 0.82)	0.47 (0.22, 0.82)
	rate	0.113 (0.069, 0.19)	0.129 (0.068, 0.307)	0.125 (0.068, 0.367)	0.127 (0.071, 0.34)	0.124 (0.071, 0.285)
++-+	graduation	0	44	161	33	33
	futility	0	0	0	0	0
	max_n	0	0	0	1	0
	n	11 (7, 16)	5 (1, 10)	5 (1, 11)	6 (2, 12)	6 (3, 13)
	n_unique	10 (6, 15)	4 (1, 10)	4 (1, 10)	5 (2, 11)	5 (2, 12)
	post_p	NA (NA, NA)	0.45 (0.22, 0.8)	0.45 (0.23, 0.78)	0.46 (0.23, 0.81)	0.45 (0.21, 0.83)
	rate	0.115 (0.074, 0.177)	0.127 (0.064, 0.352)	0.131 (0.07, 0.414)	0.124 (0.071, 0.284)	0.13 (0.069, 0.279)
+++-	graduation	0	83	409	35	32
	futility	0	0	0	0	0
	max_n	0	25	0	36	27
	n	12 (7, 17)	4 (1, 12)	3 (0, 6)	7 (3, 14)	6 (2, 14)
	n_unique	10 (6, 15)	4 (1, 11)	2 (0, 5)	6 (2, 13)	6 (2, 12)
	post_p	NA (NA, NA)	0.53 (0.26, 0.85)	0.35 (0.19, 0.52)	0.6 (0.25, 0.91)	0.53 (0.21, 0.87)
	rate	0.14 (0.09, 0.228)	0.131 (0.064, 0.352)	0.246 (0.133, 0.738)	0.121 (0.068, 0.284)	0.128 (0.074, 0.345)
++++	graduation	0	89	420	50	44
	futility	0	0	0	0	0
	max_n	0	25	0	36	27
	n	12 (7, 17)	5 (1, 12)	2 (0, 5)	7 (2, 14)	7 (3, 14)
	n_unique	11 (6, 16)	4 (1, 11)	2 (0, 5)	7 (2, 13)	6 (2, 13)
	post_p	NA (NA, NA)	0.55 (0.26, 0.85)	0.32 (0.16, 0.5)	0.6 (0.26, 0.9)	0.57 (0.25, 0.84)
	rate	0.136 (0.089, 0.227)	0.129 (0.072, 0.364)	0.28 (0.148, 1.017)	0.121 (0.074, 0.251)	0.128 (0.075, 0.278)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	ARSi	Taxane_CT	Platinum_CT	PARPi
all	count	18		1	3
	time_stop	5 (4, 9)		6 (6, 6)	7 (7, 8)
	n_trt	34 (26, 64)		26 (26, 26)	34 (32, 46)
	n_control	65 (48, 93)		79 (79, 79)	83 (79, 90)
	post_p	0.95 (0.87, 0.98)		0.92 (0.92, 0.92)	0.98 (0.89, 0.99)
	order	1 (1, 1)		1 (1, 1)	1 (1, 1)
TP53- & AR-	count	55	39	27	26
	time_stop	10 (7, 23)	12 (9, 22)	14 (10, 24)	16 (10, 31)
	n_trt	34 (26, 84)	31 (25, 67)	29 (25, 57)	44 (26, 96)
	n_control	45 (26, 107)	54 (36, 103)	59 (39, 98)	68 (46, 132)
	post_p	0.9 (0.86, 0.96)	0.92 (0.87, 0.97)	0.94 (0.89, 0.99)	0.94 (0.87, 0.98)
	order	1 (1, 2)	1 (1, 2)	1 (1, 2)	1.5 (1, 2)
TP53+	count	50		19	9
	time_stop	10 (8, 16)		15 (9, 30)	11 (9, 21)
	n_trt	29 (25, 43)		39 (28, 118)	32 (27, 75)
	n_control	44 (33, 71)		72 (40, 145)	61 (33, 96)
	post_p	0.97 (0.91, 1)		0.98 (0.93, 1)	0.98 (0.96, 1)
	order	1 (1, 2)		1 (1, 2)	1 (1, 1.2)
HRD+	count	4		2	4
	time_stop	20 (19, 21)		14 (12, 16)	15 (13, 16)
	n_trt	30 (26, 32)		34 (29, 40)	28 (25, 32)
	n_control	60 (49, 65)		38 (35, 42)	38 (31, 44)
	post_p	0.96 (0.93, 0.99)		0.97 (0.97, 0.98)	0.92 (0.88, 0.96)
	order	1 (1, 1.7)		2 (1.2, 2.8)	1 (1, 1.7)
TEfus+	count	5	1	9	9
	time_stop	14 (13, 28)	11 (11, 11)	13 (11, 16)	15 (11, 20)
	n_trt	29 (25, 83)	29 (29, 29)	29 (28, 39)	33 (27, 58)
	n_control	55 (48, 134)	46 (46, 46)	50 (36, 66)	58 (38, 81)
	post_p	0.95 (0.89, 0.99)	0.93 (0.93, 0.93)	0.97 (0.96, 0.99)	0.98 (0.88, 1)
	order	1 (1, 3)	1 (1, 1)	2 (1, 3)	1 (1, 2.4)

Futility:

signature	var	ARSi	Taxane_CT	Platinum_CT	PARPi
all	count	1	23
	time_stop	3 (3, 3)	20 (5, 32)
	n_trt	27 (27, 27)	75 (27, 99)
	n_control	35 (35, 35)	216 (49, 374)
	post_p	0.14 (0.14, 0.14)	0.01 (0, 0.13)
	order	1 (1, 1)	2 (1, 5)
TP53- & AR-	count	148	124	115	120
	time_stop	16 (8, 32)	20 (13, 32)	20 (14, 34)	21 (13, 34)
	n_trt	37 (25, 84)	33 (25, 77)	34 (25, 71)	40 (26, 82)
	n_control	68 (34, 153)	92 (56, 154)	92 (55, 174)	96 (58, 158)
	post_p	0.16 (0.05, 0.27)	0.15 (0.05, 0.26)	0.15 (0.05, 0.26)	0.15 (0.04, 0.26)
	order	2 (1, 3)	2 (1, 4)	2 (1, 4)	2 (1, 3)
TP53+	count	3	396		4
	time_stop	16 (12, 30)	17 (10, 30)		15 (10, 30)
	n_trt	42 (30, 79)	33 (25, 49)		32 (26, 76)
	n_control	70 (64, 140)	80 (42, 150)		78 (53, 182)
	post_p	0.1 (0.09, 0.13)	0.01 (0, 0.09)		0.03 (0.01, 0.1)
	order	1 (1, 5)	1 (1, 3)		1.5 (1, 2.7)
HRD+	count	13	63	14	13
	time_stop	29 (18, 34)	29 (22, 35)	17 (10, 34)	20 (11, 30)
	n_trt	29 (26, 44)	32 (26, 48)	30 (25, 49)	33 (25, 47)
	n_control	84 (45, 103)	88 (62, 112)	44 (28, 97)	48 (30, 95)
	post_p	0.1 (0.03, 0.23)	0.06 (0.01, 0.17)	0.04 (0.02, 0.24)	0.12 (0.08, 0.18)
	order	2 (1, 5.4)	3 (2, 4)	2 (1, 3)	2 (1, 3)
TEfus+	count	3	119	7	4
	time_stop	29 (24, 32)	20 (12, 32)	13 (12, 23)	21 (16, 26)
	n_trt	46 (40, 48)	34 (26, 50)	27 (25, 43)	38 (33, 50)
	n_control	109 (101, 134)	79 (40, 127)	51 (39, 96)	78 (51, 110)
	post_p	0.12 (0.06, 0.13)	0.03 (0, 0.15)	0.12 (0.05, 0.23)	0.11 (0.03, 0.23)
	order	5 (4.2, 5)	3 (1, 5)	1 (1, 3)	2.5 (1.3, 3)

By subgroup combinations

Graduation:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	ARSi	count	18	18	18	18	18	18	18	18	18	18	18	18	18	18	18	18
		time	5 (4, 9)	5 (4, 9)	5 (4, 9)	5 (4, 9)	5 (4, 9)	5 (4, 9)	5 (4, 9)	5 (4, 9)	5 (4, 9)	5 (4, 9)	5 (4, 9)	5 (4, 9)	5 (4, 9)	5 (4, 9)	5 (4, 9)	5 (4, 9)
		n	15 (11, 24)	2 (0, 7)	8 (3, 13)	3 (2, 9)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 3)	1 (0, 3)	1 (0, 5)	1 (0, 2)	0 (0, 2)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 2)
		post_p	0.57 (0.51, 0.82)	0.54 (0.52, 0.56)	0.66 (0.55, 0.8)	0.63 (0.54, 0.73)	0.53 (0.51, 0.55)	0.54 (0.51, 0.57)	0.56 (0.53, 0.71)	0.59 (0.52, 0.7)	0.56 (0.52, 0.59)	0.56 (0.52, 0.6)	0.54 (0.52, 0.58)	0.57 (0.53, 0.66)	0.55 (0.51, 0.56)	0.62 (0.6, 0.62)	0.53 (0.52, 0.53)	0.57 (0.52, 0.65)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.077 (0.034, 0.113)	0 (0, 0.179)	0.059 (0, 0.124)	0.028 (0, 0.121)	0 (0, 0.093)	0 (0, 0.127)	0 (0, 0.033)	0 (0, 0.036)	0 (0, 0)	0 (0, 0.103)	0 (0, 0.125)	0 (0, 0.079)	0 (0, 0.047)	0 (0, 0)	0 (0, 0.132)	0 (0, 0.027)
	Platinum_CT	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
		time	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)
		n	6 (6, 6)	0 (0, 0)	5 (5, 5)	3 (3, 3)	2 (2, 2)	1 (1, 1)	4 (4, 4)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	2 (2, 2)	2 (2, 2)	1 (1, 1)
		post_p	0.7 (0.7, 0.7)	NA (NA, NA)	0.61 (0.61, 0.61)	0.6 (0.6, 0.6)	0.59 (0.59, 0.59)	0.53 (0.53, 0.53)	0.71 (0.71, 0.71)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.54 (0.54, 0.54)	0.52 (0.52, 0.52)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0 (0, 0)	NA (NA, NA)	0.051 (0.051, 0.051)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.113 (0.113, 0.113)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)
	PARPi	count	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3
		time	7 (7, 8)	7 (7, 8)	7 (7, 8)	7 (7, 8)	7 (7, 8)	7 (7, 8)	7 (7, 8)	7 (7, 8)	7 (7, 8)	7 (7, 8)	7 (7, 8)	7 (7, 8)	7 (7, 8)	7 (7, 8)	7 (7, 8)	7 (7, 8)
		n	6 (4, 8)	0 (0, 2)	8 (4, 10)	0 (0, 2)	4 (2, 4)	4 (1, 6)	2 (1, 3)	5 (3, 6)	1 (0, 3)	0 (0, 0)	0 (0, 1)	1 (0, 2)	2 (1, 2)	1 (0, 3)	2 (1, 4)	2 (1, 2)
		post_p	0.64 (0.57, 0.7)	NA (NA, NA)	0.65 (0.6, 0.69)	0.61 (0.61, 0.61)	0.6 (0.53, 0.61)	0.52 (0.51, 0.53)	0.56 (0.53, 0.57)	0.52 (0.51, 0.6)	0.56 (0.55, 0.57)	NA (NA, NA)	0.53 (0.53, 0.53)	0.57 (0.55, 0.59)	0.61 (0.54, 0.79)	0.51 (0.51, 0.52)	0.58 (0.53, 0.58)	0.52 (0.52, 0.57)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0 (0, 0.081)	0 (0, 0)	0.103 (0.094, 0.127)	0 (0, 0)	0.059 (0.012, 0.073)	0.099 (0.076, 0.123)	0 (0, 0.124)	0.036 (0.007, 0.153)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0.138)	0.04 (0.008, 0.071)	0 (0, 0.079)	0 (0, 0.144)
TP53- & AR-	ARSi	count	55	55			55	55
		time	10 (7, 23)	10 (7, 23)			10 (7, 23)	10 (7, 23)
		n	25 (20, 62)	4 (1, 9)			2 (0, 6)	2 (0, 8)
		post_p	0.79 (0.72, 0.91)	0.61 (0.51, 0.77)			0.57 (0.53, 0.81)	0.58 (0.52, 0.77)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.075 (0.054, 0.102)	0.08 (0, 0.15)			0 (0, 0.145)	0 (0, 0.135)
	Taxane_CT	count	39	39			39	39
		time	12 (9, 22)	12 (9, 22)			12 (9, 22)	12 (9, 22)
		n	22 (16, 43)	4 (3, 10)			3 (1, 9)	3 (1, 7)
		post_p	0.83 (0.72, 0.92)	0.65 (0.51, 0.78)			0.61 (0.53, 0.8)	0.59 (0.52, 0.76)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.083 (0.044, 0.101)	0.065 (0.029, 0.101)			0.017 (0, 0.1)	0 (0, 0.108)
	Platinum_CT	count	27	27			27	27
		time	14 (10, 24)	14 (10, 24)			14 (10, 24)	14 (10, 24)
		n	18 (12, 38)	3 (1, 5)			5 (2, 10)	5 (2, 10)
		post_p	0.79 (0.72, 0.94)	0.6 (0.51, 0.82)			0.68 (0.55, 0.81)	0.73 (0.55, 0.82)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.07 (0.04, 0.092)	0.067 (0, 0.154)			0.056 (0, 0.112)	0.068 (0, 0.084)
	PARPi	count	26	26			26	26
		time	16 (10, 31)	16 (10, 31)			16 (10, 31)	16 (10, 31)
		n	27 (12, 60)	5 (1, 14)			5 (4, 16)	6 (2, 18)
		post_p	0.8 (0.72, 0.93)	0.72 (0.55, 0.91)			0.75 (0.58, 0.86)	0.66 (0.52, 0.8)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.077 (0.052, 0.111)	0.062 (0, 0.115)			0.061 (0.029, 0.104)	0.076 (0.045, 0.108)
TP53+	ARSi	count			50	50			50	50			50	50			50	50
		time			10 (8, 16)	10 (8, 16)			10 (8, 16)	10 (8, 16)			10 (8, 16)	10 (8, 16)			10 (8, 16)	10 (8, 16)
		n			15 (9, 21)	8 (4, 14)			1 (0, 2)	1 (0, 4)			2 (0, 5)	2 (0, 3)			1 (0, 2)	1 (0, 3)
		post_p			0.81 (0.72, 0.95)	0.75 (0.55, 0.89)			0.56 (0.52, 0.68)	0.56 (0.52, 0.65)			0.6 (0.53, 0.81)	0.56 (0.52, 0.67)			0.55 (0.5, 0.67)	0.56 (0.52, 0.72)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.078 (0.037, 0.114)	0.076 (0.017, 0.132)			0 (0, 0.131)	0 (0, 0.188)			0.026 (0, 0.138)	0 (0, 0.198)			0 (0, 0.079)	0 (0, 0.128)
	Platinum_CT	count			19	19			19	19			19	19			19	19
		time			15 (9, 30)	15 (9, 30)			15 (9, 30)	15 (9, 30)			15 (9, 30)	15 (9, 30)			15 (9, 30)	15 (9, 30)
		n			13 (7, 46)	10 (2, 24)			3 (1, 4)	4 (1, 8)			3 (1, 7)	4 (1, 9)			5 (3, 10)	3 (2, 7)
		post_p			0.84 (0.73, 0.98)	0.78 (0.58, 0.9)			0.57 (0.51, 0.82)	0.58 (0.51, 0.87)			0.59 (0.51, 0.91)	0.65 (0.53, 0.82)			0.66 (0.56, 0.85)	0.58 (0.53, 0.85)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.085 (0.031, 0.11)	0.076 (0.041, 0.121)			0.079 (0, 0.143)	0.073 (0, 0.136)			0.108 (0, 0.207)	0.087 (0, 0.12)			0.089 (0, 0.115)	0.077 (0, 0.152)
	PARPi	count			9	9			9	9			9	9			9	9
		time			11 (9, 21)	11 (9, 21)			11 (9, 21)	11 (9, 21)			11 (9, 21)	11 (9, 21)			11 (9, 21)	11 (9, 21)
		n			12 (8, 27)	7 (3, 16)			3 (2, 5)	3 (3, 7)			3 (2, 5)	2 (0, 5)			3 (2, 5)	3 (1, 5)
		post_p			0.86 (0.67, 0.93)	0.74 (0.54, 0.87)			0.63 (0.54, 0.83)	0.55 (0.51, 0.78)			0.63 (0.56, 0.74)	0.69 (0.57, 0.79)			0.57 (0.52, 0.61)	0.62 (0.57, 0.92)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.077 (0.036, 0.115)	0.076 (0, 0.131)			0.042 (0, 0.108)	0.108 (0.088, 0.139)			0.075 (0, 0.117)	0.108 (0.037, 0.177)			0 (0, 0.112)	0.034 (0, 0.115)
HRD+	ARSi	count					4	4	4	4					4	4	4	4
		time					20 (19, 21)	20 (19, 21)	20 (19, 21)	20 (19, 21)					20 (19, 21)	20 (19, 21)	20 (19, 21)	20 (19, 21)
		n					4 (4, 5)	4 (3, 11)	3 (1, 4)	4 (2, 6)					4 (1, 5)	4 (2, 6)	1 (0, 2)	4 (2, 5)
		post_p					0.69 (0.56, 0.79)	0.66 (0.54, 0.74)	0.56 (0.53, 0.56)	0.77 (0.59, 0.84)					0.74 (0.6, 0.78)	0.72 (0.64, 0.79)	0.67 (0.54, 0.71)	0.64 (0.57, 0.78)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.09 (0.068, 0.131)	0.092 (0.021, 0.125)	0.135 (0.131, 0.196)	0.069 (0.012, 0.13)					0.072 (0.067, 0.08)	0.021 (0, 0.061)	0 (0, 0.065)	0.077 (0.053, 0.098)
	Platinum_CT	count					2	2	2	2					2	2	2	2
		time					14 (12, 16)	14 (12, 16)	14 (12, 16)	14 (12, 16)					14 (12, 16)	14 (12, 16)	14 (12, 16)	14 (12, 16)
		n					4 (3, 5)	5 (3, 7)	4 (3, 5)	6 (5, 7)					3 (1, 5)	3 (3, 3)	7 (2, 12)	2 (2, 3)
		post_p					0.57 (0.55, 0.59)	0.72 (0.6, 0.84)	0.74 (0.65, 0.83)	0.74 (0.58, 0.9)					0.73 (0.7, 0.77)	0.59 (0.53, 0.66)	0.72 (0.63, 0.82)	0.57 (0.53, 0.62)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.079 (0.061, 0.097)	0.08 (0.064, 0.096)	0.072 (0.045, 0.1)	0.078 (0.059, 0.097)					0.031 (0.006, 0.056)	0.079 (0.016, 0.143)	0.072 (0.014, 0.13)	0.085 (0.077, 0.094)
	PARPi	count					4	4	4	4					4	4	4	4
		time					15 (13, 16)	15 (13, 16)	15 (13, 16)	15 (13, 16)					15 (13, 16)	15 (13, 16)	15 (13, 16)	15 (13, 16)
		n					4 (2, 6)	6 (5, 8)	4 (3, 4)	1 (0, 3)					4 (3, 5)	4 (1, 6)	2 (1, 4)	4 (2, 5)
		post_p					0.64 (0.55, 0.82)	0.64 (0.54, 0.81)	0.59 (0.55, 0.63)	0.57 (0.55, 0.6)					0.55 (0.53, 0.57)	0.6 (0.55, 0.84)	0.52 (0.52, 0.56)	0.6 (0.58, 0.64)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.069 (0.017, 0.084)	0.052 (0.038, 0.077)	0.063 (0.016, 0.073)	0.11 (0.101, 0.119)					0.118 (0.098, 0.162)	0.079 (0.057, 0.105)	0.145 (0.098, 0.204)	0.109 (0.032, 0.132)
TEfus+	ARSi	count		5		5		5		5		5		5		5		5
		time		14 (13, 28)		14 (13, 28)		14 (13, 28)		14 (13, 28)		14 (13, 28)		14 (13, 28)		14 (13, 28)		14 (13, 28)
		n		4 (3, 6)		10 (5, 31)		1 (0, 4)		1 (0, 6)		3 (2, 15)		3 (1, 13)		3 (2, 12)		2 (1, 8)
		post_p		0.64 (0.57, 0.74)		0.72 (0.62, 0.9)		0.57 (0.56, 0.62)		0.68 (0.57, 0.84)		0.63 (0.56, 0.69)		0.57 (0.54, 0.75)		0.58 (0.51, 0.8)		0.61 (0.59, 0.69)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.056 (0.025, 0.076)		0.103 (0.09, 0.139)		0.1 (0.02, 0.11)		0.051 (0.01, 0.109)		0.027 (0, 0.082)		0.057 (0, 0.114)		0.075 (0.066, 0.142)		0 (0, 0.119)
	Taxane_CT	count		1		1		1		1		1		1		1		1
		time		11 (11, 11)		11 (11, 11)		11 (11, 11)		11 (11, 11)		11 (11, 11)		11 (11, 11)		11 (11, 11)		11 (11, 11)
		n		4 (4, 4)		9 (9, 9)		4 (4, 4)		2 (2, 2)		3 (3, 3)		2 (2, 2)		1 (1, 1)		4 (4, 4)
		post_p		0.59 (0.59, 0.59)		0.8 (0.8, 0.8)		0.66 (0.66, 0.66)		NA (NA, NA)		0.53 (0.53, 0.53)		0.52 (0.52, 0.52)		0.53 (0.53, 0.53)		0.53 (0.53, 0.53)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0.034 (0.034, 0.034)		0.169 (0.169, 0.169)		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0.08 (0.08, 0.08)		0 (0, 0)		0.133 (0.133, 0.133)
	Platinum_CT	count		9		9		9		9		9		9		9		9
		time		13 (11, 16)		13 (11, 16)		13 (11, 16)		13 (11, 16)		13 (11, 16)		13 (11, 16)		13 (11, 16)		13 (11, 16)
		n		3 (1, 4)		8 (4, 15)		5 (2, 7)		3 (1, 5)		3 (1, 5)		4 (1, 5)		3 (1, 4)		3 (0, 5)
		post_p		0.56 (0.51, 0.6)		0.8 (0.63, 0.93)		0.72 (0.54, 0.76)		0.52 (0.51, 0.66)		0.54 (0.52, 0.65)		0.63 (0.57, 0.76)		0.55 (0.53, 0.69)		0.54 (0.51, 0.66)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.073 (0, 0.142)		0.063 (0.028, 0.096)		0.047 (0.025, 0.104)		0.035 (0, 0.119)		0.066 (0, 0.166)		0.067 (0.03, 0.129)		0.053 (0, 0.121)		0.089 (0.034, 0.143)
	PARPi	count		9		9		9		9		9		9		9		9
		time		15 (11, 20)		15 (11, 20)		15 (11, 20)		15 (11, 20)		15 (11, 20)		15 (11, 20)		15 (11, 20)		15 (11, 20)
		n		3 (2, 7)		6 (2, 15)		6 (5, 10)		4 (2, 5)		4 (0, 8)		4 (1, 9)		3 (1, 6)		4 (4, 7)
		post_p		0.61 (0.53, 0.75)		0.83 (0.56, 0.92)		0.72 (0.52, 0.81)		0.64 (0.53, 0.68)		0.73 (0.57, 0.88)		0.72 (0.6, 0.85)		0.58 (0.51, 0.73)		0.58 (0.51, 0.8)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.071 (0, 0.118)		0.054 (0.036, 0.126)		0.07 (0.037, 0.133)		0.103 (0.036, 0.163)		0.079 (0, 0.114)		0.073 (0.028, 0.104)		0.073 (0, 0.104)		0.096 (0.03, 0.111)

Futility:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	ARSi	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
		time	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)
		n	10 (10, 10)	1 (1, 1)	9 (9, 9)	4 (4, 4)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	1 (1, 1)	0 (0, 0)	2 (2, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		post_p	0.39 (0.39, 0.39)	NA (NA, NA)	0.42 (0.42, 0.42)	0.47 (0.47, 0.47)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.45 (0.45, 0.45)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.203 (0.203, 0.203)	0 (0, 0)	0.128 (0.128, 0.128)	0.195 (0.195, 0.195)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0.387 (0.387, 0.387)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
	Taxane_CT	count	23	23	23	23	23	23	23	23	23	23	23	23	23	23	23	23
		time	20 (5, 32)	20 (5, 32)	20 (5, 32)	20 (5, 32)	20 (5, 32)	20 (5, 32)	20 (5, 32)	20 (5, 32)	20 (5, 32)	20 (5, 32)	20 (5, 32)	20 (5, 32)	20 (5, 32)	20 (5, 32)	20 (5, 32)	20 (5, 32)
		n	10 (3, 27)	3 (0, 8)	6 (3, 11)	7 (3, 12)	3 (0, 8)	3 (0, 8)	1 (0, 5)	1 (0, 4)	4 (2, 10)	5 (1, 10)	4 (1, 8)	4 (3, 6)	3 (0, 5)	2 (0, 5)	2 (0, 5)	1 (0, 4)
		post_p	0.27 (0.11, 0.42)	0.36 (0.22, 0.48)	0.23 (0.09, 0.4)	0.17 (0.07, 0.41)	0.39 (0.29, 0.48)	0.42 (0.27, 0.47)	0.36 (0.21, 0.47)	0.41 (0.23, 0.47)	0.35 (0.15, 0.47)	0.38 (0.21, 0.49)	0.34 (0.17, 0.43)	0.33 (0.11, 0.41)	0.41 (0.22, 0.48)	0.33 (0.13, 0.46)	0.4 (0.2, 0.49)	0.36 (0.22, 0.47)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.177 (0.117, 0.418)	0.172 (0.128, 0.312)	0.229 (0.169, 0.366)	0.241 (0.166, 0.673)	0.153 (0.13, 0.322)	0.159 (0.107, 0.419)	0.518 (0.19, 9.721)	0.43 (0.177, 0.85)	0.159 (0.09, 0.254)	0.169 (0.079, 0.286)	0.272 (0.109, 0.478)	0.256 (0.145, 0.488)	0.159 (0.092, 0.616)	0.163 (0.108, 0.625)	0.21 (0.133, 1.181)	0.312 (0.161, 1.096)
TP53- & AR-	ARSi	count	148	148			148	148
		time	16 (8, 32)	16 (8, 32)			16 (8, 32)	16 (8, 32)
		n	25 (16, 61)	5 (2, 11)			3 (0, 10)	3 (1, 10)
		post_p	0.33 (0.11, 0.45)	0.39 (0.18, 0.48)			0.4 (0.22, 0.48)	0.4 (0.23, 0.48)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.129 (0.103, 0.17)	0.153 (0.097, 0.35)			0.183 (0.111, 0.683)	0.186 (0.111, 0.802)
	Taxane_CT	count	124	124			124	124
		time	20 (13, 32)	20 (13, 32)			20 (13, 32)	20 (13, 32)
		n	18 (11, 53)	5 (3, 11)			4 (2, 13)	4 (1, 9)
		post_p	0.34 (0.12, 0.48)	0.34 (0.19, 0.48)			0.4 (0.21, 0.49)	0.39 (0.26, 0.49)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.127 (0.104, 0.18)	0.162 (0.103, 0.376)			0.158 (0.107, 0.389)	0.157 (0.107, 0.37)
	Platinum_CT	count	115	115			115	115
		time	20 (14, 34)	20 (14, 34)			20 (14, 34)	20 (14, 34)
		n	18 (7, 47)	4 (2, 11)			6 (3, 13)	6 (3, 12)
		post_p	0.33 (0.08, 0.48)	0.39 (0.19, 0.48)			0.36 (0.19, 0.48)	0.35 (0.19, 0.48)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.132 (0.107, 0.227)	0.158 (0.1, 0.505)			0.158 (0.107, 0.281)	0.156 (0.101, 0.37)
	PARPi	count	120	120			120	120
		time	21 (13, 34)	21 (13, 34)			21 (13, 34)	21 (13, 34)
		n	20 (10, 59)	5 (2, 11)			6 (4, 13)	6 (2, 13)
		post_p	0.3 (0.13, 0.45)	0.39 (0.23, 0.49)			0.36 (0.17, 0.47)	0.35 (0.18, 0.47)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.134 (0.103, 0.187)	0.163 (0.105, 0.306)			0.153 (0.105, 0.288)	0.156 (0.1, 0.357)
TP53+	ARSi	count			3	3			3	3			3	3			3	3
		time			16 (12, 30)	16 (12, 30)			16 (12, 30)	16 (12, 30)			16 (12, 30)	16 (12, 30)			16 (12, 30)	16 (12, 30)
		n			20 (17, 36)	12 (6, 20)			1 (0, 7)	0 (0, 2)			2 (1, 4)	2 (1, 3)			4 (2, 5)	2 (1, 4)
		post_p			0.39 (0.37, 0.4)	0.4 (0.26, 0.48)			0.45 (0.42, 0.47)	0.42 (0.42, 0.42)			0.35 (0.27, 0.41)	0.35 (0.25, 0.36)			0.42 (0.41, 0.43)	0.36 (0.3, 0.43)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.145 (0.111, 0.162)	0.117 (0.115, 0.274)			0.193 (0.146, 0.24)	0.186 (0.186, 0.186)			0.367 (0.252, 0.655)	0.188 (0.18, 0.649)			0.24 (0.153, 0.377)	0.648 (0.312, 5.52)
	Taxane_CT	count			396	396			396	396			396	396			396	396
		time			17 (10, 30)	17 (10, 30)			17 (10, 30)	17 (10, 30)			17 (10, 30)	17 (10, 30)			17 (10, 30)	17 (10, 30)
		n			7 (4, 14)	8 (5, 13)			2 (0, 5)	2 (0, 5)			4 (2, 7)	4 (2, 7)			2 (0, 5)	2 (0, 5)
		post_p			0.2 (0.07, 0.42)	0.2 (0.07, 0.41)			0.39 (0.22, 0.48)	0.4 (0.25, 0.48)			0.34 (0.17, 0.47)	0.31 (0.14, 0.46)			0.4 (0.24, 0.48)	0.38 (0.22, 0.48)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.245 (0.159, 0.458)	0.233 (0.16, 0.414)			0.285 (0.142, 1.155)	0.292 (0.141, 0.99)			0.241 (0.141, 0.565)	0.252 (0.149, 0.578)			0.263 (0.131, 0.887)	0.284 (0.151, 1.02)
	PARPi	count			4	4			4	4			4	4			4	4
		time			15 (10, 30)	15 (10, 30)			15 (10, 30)	15 (10, 30)			15 (10, 30)	15 (10, 30)			15 (10, 30)	15 (10, 30)
		n			10 (7, 17)	8 (3, 21)			3 (1, 8)	3 (1, 10)			2 (1, 8)	5 (3, 8)			0 (0, 2)	4 (2, 6)
		post_p			0.23 (0.22, 0.24)	0.44 (0.29, 0.49)			0.29 (0.25, 0.33)	0.36 (0.21, 0.41)			0.42 (0.37, 0.47)	0.4 (0.36, 0.48)			0.42 (0.36, 0.48)	0.36 (0.2, 0.46)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.188 (0.152, 0.273)	0.25 (0.164, 0.35)			0.155 (0.113, 0.309)	0.302 (0.174, 0.807)			0.733 (0.253, 1.011)	0.149 (0.1, 0.243)			0.15 (0.142, 0.158)	0.256 (0.156, 0.342)
HRD+	ARSi	count					13	13	13	13					13	13	13	13
		time					29 (18, 34)	29 (18, 34)	29 (18, 34)	29 (18, 34)					29 (18, 34)	29 (18, 34)	29 (18, 34)	29 (18, 34)
		n					5 (2, 11)	6 (2, 11)	3 (0, 5)	2 (0, 6)					3 (2, 6)	4 (2, 8)	3 (0, 7)	2 (1, 4)
		post_p					0.35 (0.25, 0.48)	0.38 (0.25, 0.48)	0.39 (0.3, 0.47)	0.44 (0.32, 0.48)					0.43 (0.25, 0.47)	0.33 (0.21, 0.47)	0.45 (0.25, 0.49)	0.38 (0.14, 0.49)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.174 (0.101, 0.226)	0.158 (0.116, 0.315)	0.192 (0.146, 0.303)	0.157 (0.097, 0.588)					0.181 (0.124, 0.296)	0.158 (0.111, 0.427)	0.178 (0.09, 0.234)	0.258 (0.158, 0.513)
	Taxane_CT	count					63	63	63	63					63	63	63	63
		time					29 (22, 35)	29 (22, 35)	29 (22, 35)	29 (22, 35)					29 (22, 35)	29 (22, 35)	29 (22, 35)	29 (22, 35)
		n					6 (2, 18)	5 (2, 12)	2 (0, 7)	2 (1, 6)					3 (1, 9)	4 (1, 8)	3 (1, 5)	3 (1, 6)
		post_p					0.37 (0.2, 0.49)	0.33 (0.16, 0.47)	0.34 (0.17, 0.48)	0.32 (0.19, 0.47)					0.4 (0.25, 0.48)	0.36 (0.21, 0.48)	0.34 (0.19, 0.48)	0.34 (0.2, 0.46)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.145 (0.098, 0.398)	0.169 (0.105, 0.322)	0.299 (0.184, 1.501)	0.28 (0.147, 0.724)					0.172 (0.098, 0.51)	0.171 (0.107, 0.476)	0.259 (0.146, 1.15)	0.248 (0.156, 0.62)
	Platinum_CT	count					14	14	14	14					14	14	14	14
		time					17 (10, 34)	17 (10, 34)	17 (10, 34)	17 (10, 34)					17 (10, 34)	17 (10, 34)	17 (10, 34)	17 (10, 34)
		n					6 (4, 11)	4 (3, 10)	5 (1, 6)	4 (0, 8)					3 (1, 5)	3 (0, 6)	2 (2, 4)	4 (1, 5)
		post_p					0.35 (0.15, 0.42)	0.39 (0.3, 0.47)	0.43 (0.29, 0.49)	0.44 (0.36, 0.48)					0.42 (0.24, 0.47)	0.38 (0.23, 0.49)	0.39 (0.23, 0.49)	0.36 (0.24, 0.49)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.168 (0.111, 0.207)	0.144 (0.09, 0.311)	0.141 (0.114, 0.256)	0.164 (0.118, 0.243)					0.209 (0.127, 0.684)	0.203 (0.104, 0.448)	0.227 (0.14, 0.401)	0.195 (0.105, 0.305)
	PARPi	count					13	13	13	13					13	13	13	13
		time					20 (11, 30)	20 (11, 30)	20 (11, 30)	20 (11, 30)					20 (11, 30)	20 (11, 30)	20 (11, 30)	20 (11, 30)
		n					6 (2, 12)	6 (2, 11)	4 (2, 7)	3 (2, 7)					3 (2, 7)	3 (1, 6)	3 (0, 5)	3 (2, 7)
		post_p					0.43 (0.23, 0.48)	0.43 (0.31, 0.48)	0.39 (0.28, 0.49)	0.39 (0.26, 0.48)					0.44 (0.3, 0.46)	0.39 (0.28, 0.42)	0.42 (0.32, 0.49)	0.43 (0.28, 0.46)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.134 (0.072, 0.29)	0.137 (0.101, 0.292)	0.261 (0.124, 0.406)	0.17 (0.12, 0.373)					0.132 (0.076, 0.269)	0.236 (0.148, 0.806)	0.193 (0.101, 0.316)	0.191 (0.092, 0.358)
TEfus+	ARSi	count		3		3		3		3		3		3		3		3
		time		29 (24, 32)		29 (24, 32)		29 (24, 32)		29 (24, 32)		29 (24, 32)		29 (24, 32)		29 (24, 32)		29 (24, 32)
		n		3 (3, 6)		13 (7, 17)		1 (0, 3)		3 (2, 6)		8 (4, 10)		9 (3, 11)		3 (2, 10)		3 (2, 3)
		post_p		0.36 (0.34, 0.39)		0.41 (0.27, 0.45)		0.34 (0.32, 0.36)		0.41 (0.32, 0.47)		0.31 (0.22, 0.46)		0.32 (0.22, 0.43)		0.33 (0.17, 0.45)		0.44 (0.27, 0.44)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.149 (0.128, 0.166)		0.158 (0.121, 0.281)		2.268 (0.634, 3.901)		0.159 (0.14, 0.21)		0.116 (0.112, 0.479)		0.259 (0.158, 0.685)		0.238 (0.109, 0.247)		0.197 (0.159, 0.263)
	Taxane_CT	count		119		119		119		119		119		119		119		119
		time		20 (12, 32)		20 (12, 32)		20 (12, 32)		20 (12, 32)		20 (12, 32)		20 (12, 32)		20 (12, 32)		20 (12, 32)
		n		5 (2, 11)		9 (5, 13)		4 (1, 8)		2 (0, 4)		5 (2, 9)		4 (2, 6)		3 (0, 6)		2 (0, 5)
		post_p		0.36 (0.19, 0.48)		0.18 (0.05, 0.37)		0.38 (0.23, 0.48)		0.38 (0.21, 0.47)		0.38 (0.22, 0.48)		0.27 (0.13, 0.45)		0.39 (0.24, 0.48)		0.39 (0.21, 0.48)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0.153 (0.094, 0.299)		0.234 (0.17, 0.372)		0.159 (0.104, 0.398)		0.306 (0.159, 1.03)		0.148 (0.102, 0.322)		0.256 (0.153, 0.523)		0.194 (0.1, 0.607)		0.295 (0.156, 0.765)
	Platinum_CT	count		7		7		7		7		7		7		7		7
		time		13 (12, 23)		13 (12, 23)		13 (12, 23)		13 (12, 23)		13 (12, 23)		13 (12, 23)		13 (12, 23)		13 (12, 23)
		n		4 (0, 4)		6 (3, 8)		7 (5, 9)		3 (1, 3)		3 (0, 6)		3 (2, 7)		5 (2, 7)		3 (0, 4)
		post_p		0.4 (0.36, 0.45)		0.4 (0.24, 0.45)		0.42 (0.35, 0.45)		0.44 (0.34, 0.46)		0.34 (0.22, 0.42)		0.37 (0.3, 0.47)		0.42 (0.37, 0.44)		0.41 (0.28, 0.44)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.155 (0.119, 0.718)		0.209 (0.185, 0.241)		0.137 (0.112, 0.226)		0.304 (0.142, 0.375)		0.206 (0.138, 0.294)		0.2 (0.12, 0.398)		0.15 (0.124, 0.199)		0.193 (0.157, 0.949)
	PARPi	count		4		4		4		4		4		4		4		4
		time		21 (16, 26)		21 (16, 26)		21 (16, 26)		21 (16, 26)		21 (16, 26)		21 (16, 26)		21 (16, 26)		21 (16, 26)
		n		5 (3, 12)		6 (2, 9)		10 (5, 14)		4 (1, 7)		2 (1, 3)		3 (2, 4)		2 (2, 6)		6 (4, 8)
		post_p		0.33 (0.23, 0.43)		0.26 (0.15, 0.39)		0.43 (0.31, 0.46)		0.41 (0.24, 0.46)		0.4 (0.34, 0.43)		0.29 (0.16, 0.36)		0.47 (0.41, 0.48)		0.41 (0.29, 0.47)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.161 (0.13, 0.361)		0.271 (0.176, 0.342)		0.13 (0.1, 0.236)		0.147 (0.112, 0.693)		0.3 (0.221, 2.686)		0.382 (0.22, 0.606)		0.15 (0.142, 0.188)		0.194 (0.14, 0.315)