Simulation scenario 7, CR phase

Setting description

Several treatments more effective in distinctive signatures: (ARSi, TP53- & AR-); (Taxane_CT, TEfus+); (Platinum_CT and PARPi, HRD+)

Simulations setting

Survival curves (by signature)

PFS distributions (by signature)

Treatment effects (by signature)

signature	var	Other	ARSi	Taxane_CT	Platinum_CT	PARPi
all	param	scale = 0.138, shape = 1.05	scale = 0.102, shape = 1.05	scale = 0.103, shape = 1.05	scale = 0.11, shape = 1.05	scale = 0.11, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 9.6, median = 6.9	mean = 9.5, median = 6.8	mean = 8.9, median = 6.4	mean = 8.9, median = 6.4
	effect	af = 1, hr = 1	af = 1.35, hr = 0.73	af = 1.34, hr = 0.74	af = 1.25, hr = 0.79	af = 1.25, hr = 0.79
TP53- & AR-	param	scale = 0.138, shape = 1.05	scale = 0.048, shape = 1.05	scale = 0.114, shape = 1.05	scale = 0.113, shape = 1.05	scale = 0.113, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 20.5, median = 14.8	mean = 8.6, median = 6.2	mean = 8.7, median = 6.2	mean = 8.7, median = 6.2
	effect	af = 1, hr = 1	af = 2.89, hr = 0.33	af = 1.21, hr = 0.82	af = 1.22, hr = 0.81	af = 1.22, hr = 0.81
TP53+	param	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.095, shape = 1.05	scale = 0.111, shape = 1.05	scale = 0.111, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 10.3, median = 7.4	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1.45, hr = 0.68	af = 1.24, hr = 0.8	af = 1.24, hr = 0.8
HRD+	param	scale = 0.138, shape = 1.05	scale = 0.116, shape = 1.05	scale = 0.095, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 8.5, median = 6.1	mean = 10.3, median = 7.4	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7
	effect	af = 1, hr = 1	af = 1.19, hr = 0.83	af = 1.45, hr = 0.68	af = 3.86, hr = 0.24	af = 3.86, hr = 0.24
TEfus+	param	scale = 0.138, shape = 1.05	scale = 0.118, shape = 1.05	scale = 0.042, shape = 1.05	scale = 0.1, shape = 1.05	scale = 0.1, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 8.3, median = 6	mean = 23.5, median = 16.9	mean = 9.8, median = 7.1	mean = 9.8, median = 7.1
	effect	af = 1, hr = 1	af = 1.17, hr = 0.85	af = 3.31, hr = 0.28	af = 1.38, hr = 0.71	af = 1.38, hr = 0.71

Survival curves (by subgroup)

PFS distributions (by subgroup)

Treatment effects (by subgroup)

subtype	var	Other	ARSi	Taxane_CT	Platinum_CT	PARPi
—-	param	scale = 0.138, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 27.4, median = 19.7	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1
	effect	af = 1, hr = 1	af = 3.86, hr = 0.24	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—+	param	scale = 0.138, shape = 1.05	scale = 0.05, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 19.4, median = 14	mean = 27.4, median = 19.7	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1
	effect	af = 1, hr = 1	af = 2.73, hr = 0.35	af = 3.86, hr = 0.24	af = 1, hr = 1	af = 1, hr = 1
–+-	param	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–++	param	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 27.4, median = 19.7	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.86, hr = 0.24	af = 1, hr = 1	af = 1, hr = 1
-+–	param	scale = 0.138, shape = 1.05	scale = 0.076, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 12.9, median = 9.3	mean = 7.1, median = 5.1	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7
	effect	af = 1, hr = 1	af = 1.82, hr = 0.53	af = 1, hr = 1	af = 3.86, hr = 0.24	af = 3.86, hr = 0.24
-+-+	param	scale = 0.138, shape = 1.05	scale = 0.076, shape = 1.05	scale = 0.047, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 12.9, median = 9.3	mean = 21, median = 15.1	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7
	effect	af = 1, hr = 1	af = 1.82, hr = 0.53	af = 2.96, hr = 0.32	af = 3.86, hr = 0.24	af = 3.86, hr = 0.24
-++-	param	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.86, hr = 0.24	af = 3.86, hr = 0.24
-+++	param	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.047, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 21, median = 15.1	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.96, hr = 0.32	af = 3.86, hr = 0.24	af = 3.86, hr = 0.24
+—	param	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+–+	param	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 27.4, median = 19.7	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.86, hr = 0.24	af = 1, hr = 1	af = 1, hr = 1
+-+-	param	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-++	param	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 27.4, median = 19.7	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.86, hr = 0.24	af = 1, hr = 1	af = 1, hr = 1
++–	param	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.86, hr = 0.24	af = 3.86, hr = 0.24
++-+	param	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.058, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 17, median = 12.2	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.39, hr = 0.4	af = 3.86, hr = 0.24	af = 3.86, hr = 0.24
+++-	param	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.86, hr = 0.24	af = 3.86, hr = 0.24
++++	param	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.058, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 17, median = 12.2	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.39, hr = 0.4	af = 3.86, hr = 0.24	af = 3.86, hr = 0.24

Errors and power

graduation (counts and proportions):

ARSi Taxane_CT Platinum_CT PARPi all 13 5 3 2 TP53- & AR- 223 2 6 1 TP53+ 1 24 6 6 HRD+ 0 0 191 181 TEfus+ 0 127 2 2

ARSi Taxane_CT Platinum_CT PARPi all 0.026 0.010 0.006 0.004 TP53- & AR- 0.446 0.004 0.012 0.002 TP53+ 0.002 0.048 0.012 0.012 HRD+ 0.000 0.000 0.382 0.362 TEfus+ 0.000 0.254 0.004 0.004

futility (counts and proportions):

ARSi Taxane_CT Platinum_CT PARPi all 4 0 0 0 TP53- & AR- 2 60 34 31 TP53+ 189 0 2 1 HRD+ 108 16 0 0 TEfus+ 143 0 3 4

ARSi Taxane_CT Platinum_CT PARPi all 0.008 0.000 0.000 0.000 TP53- & AR- 0.004 0.120 0.068 0.062 TP53+ 0.378 0.000 0.004 0.002 HRD+ 0.216 0.032 0.000 0.000 TEfus+ 0.286 0.000 0.006 0.008

max sample size (counts and proportions):

ARSi Taxane_CT Platinum_CT PARPi all 0 0 0 0 TP53- & AR- 110 8 21 28 TP53+ 1 40 8 4 HRD+ 0 0 0 0 TEfus+ 0 17 1 0

ARSi Taxane_CT Platinum_CT PARPi all 0.000 0.000 0.000 0.000 TP53- & AR- 0.220 0.016 0.042 0.056 TP53+ 0.002 0.080 0.016 0.008 HRD+ 0.000 0.000 0.000 0.000 TEfus+ 0.000 0.034 0.002 0.000

Errors & power

The overall error was 0.078.
The corresponding errors separate for the different treatments were:

       ARSi   Taxane_CT Platinum_CT       PARPi 
      0.020       0.036       0.018       0.008 

The overall power was 0.86.
The corresponding power separate for the different treatments were:

       ARSi   Taxane_CT Platinum_CT       PARPi 
      0.446       0.254       0.382       0.362 

Median results at the end of the trial

By signature:

signature	var	Control	ARSi	Taxane_CT	Platinum_CT	PARPi
all	graduation	0	13	5	3	2
	futility	0	4	0	0	0
	max_n	0	0	0	0	0
	n	442 (414, 474)	192 (92, 255)	194 (115, 260)	164 (116, 245)	170 (127, 245)
	n_unique	405 (379, 434)	179 (86, 241)	180 (104, 243)	151 (107, 230)	157 (116, 230)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	4 (4, 6)	5 (5, 6)	6 (5, 7)	7 (6, 8)
	post_p	NA (NA, NA)	1 (0.39, 1)	1 (0.83, 1)	0.97 (0.55, 1)	0.97 (0.53, 1)
	rate	0.095 (0.088, 0.103)	0.069 (0.056, 0.094)	0.068 (0.058, 0.083)	0.075 (0.062, 0.09)	0.075 (0.061, 0.091)
TP53- & AR-	graduation	0	223	2	6	1
	futility	0	2	60	34	31
	max_n	0	110	8	21	28
	n	191 (171, 210)	126 (26, 152)	46 (25, 102)	49 (28, 129)	52 (31, 138)
	n_unique	176 (157, 194)	121 (25, 146)	42 (23, 97)	44 (26, 122)	48 (28, 131)
	time_trial	36 (36, 36)	36 (7, 36)	36 (31, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	9 (7, 16)	20 (12, 34)	16 (12, 23)	16 (13, 26)
	post_p	NA (NA, NA)	1 (0.98, 1)	0.48 (0.04, 0.92)	0.65 (0.04, 0.97)	0.63 (0.02, 0.98)
	rate	0.077 (0.068, 0.087)	0.039 (0.031, 0.047)	0.076 (0.055, 0.109)	0.07 (0.051, 0.102)	0.071 (0.048, 0.103)
TP53+	graduation	0	1	24	6	6
	futility	0	189	0	2	1
	max_n	0	1	40	8	4
	n	191 (171, 214)	61 (27, 99)	108 (54, 146)	81 (50, 119)	82 (55, 116)
	n_unique	175 (156, 195)	57 (25, 94)	100 (50, 138)	74 (46, 111)	76 (50, 107)
	time_trial	36 (36, 36)	36 (15, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	20 (11, 32)	11 (9, 19)	12 (10, 16)	12 (10, 21)
	post_p	NA (NA, NA)	0.06 (0, 0.35)	1 (0.96, 1)	0.96 (0.68, 1)	0.98 (0.63, 1)
	rate	0.112 (0.099, 0.126)	0.142 (0.122, 0.181)	0.064 (0.051, 0.08)	0.08 (0.062, 0.101)	0.08 (0.062, 0.101)
HRD+	graduation	0	0	0	191	181
	futility	0	108	16	0	0
	max_n	0	0	0	0	0
	n	110 (96, 129)	27 (18, 43)	40 (23, 59)	74 (33, 101)	77 (41, 98)
	n_unique	100 (86, 116)	25 (16, 40)	37 (20, 55)	70 (31, 94)	71 (38, 92)
	time_trial	36 (36, 36)	36 (27, 36)	36 (36, 36)	36 (17, 36)	36 (19, 36)
	time_stop	NA (NA, NA)	27 (20, 35)	26 (20, 32)	25 (13, 35)	25 (14, 35)
	post_p	NA (NA, NA)	0.2 (0.03, 0.67)	0.82 (0.34, 0.98)	1 (1, 1)	1 (1, 1)
	rate	0.105 (0.089, 0.122)	0.118 (0.09, 0.162)	0.079 (0.06, 0.103)	0.035 (0.028, 0.044)	0.035 (0.028, 0.043)
TEfus+	graduation	0	0	127	2	2
	futility	0	143	0	3	4
	max_n	0	0	17	1	0
	n	160 (141, 179)	39 (25, 63)	116 (35, 140)	61 (41, 91)	62 (42, 91)
	n_unique	146 (128, 162)	35 (22, 59)	108 (32, 131)	56 (38, 85)	57 (38, 85)
	time_trial	36 (36, 36)	36 (20, 36)	36 (13, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	23 (16, 32)	15 (10, 30)	12 (10, 19)	12 (12, 20)
	post_p	NA (NA, NA)	0.07 (0.01, 0.43)	1 (1, 1)	0.83 (0.32, 0.99)	0.86 (0.36, 0.99)
	rate	0.08 (0.071, 0.091)	0.108 (0.082, 0.137)	0.038 (0.032, 0.045)	0.064 (0.05, 0.084)	0.063 (0.048, 0.081)

By subgroup combinations:

subtype	var	Control	ARSi	Taxane_CT	Platinum_CT	PARPi
—-	graduation	0	239	67	43	34
	futility	0	0	0	0	0
	max_n	0	110	8	21	28
	n	127 (110, 144)	104 (21, 127)	15 (7, 74)	15 (7, 90)	15 (7, 98)
	n_unique	119 (103, 136)	98 (21, 122)	13 (6, 71)	13 (6, 86)	14 (6, 94)
	post_p	NA (NA, NA)	1 (0.99, 1)	0.06 (0, 0.19)	0.05 (0, 0.19)	0.06 (0, 0.19)
	rate	0.078 (0.067, 0.092)	0.035 (0.029, 0.044)	0.146 (0.111, 0.239)	0.147 (0.112, 0.264)	0.148 (0.114, 0.246)
—+	graduation	0	318	185	48	39
	futility	0	0	0	0	0
	max_n	0	109	24	22	28
	n	22 (16, 29)	5 (2, 19)	16 (4, 26)	5 (3, 12)	5 (3, 14)
	n_unique	20 (14, 27)	5 (2, 18)	14 (4, 24)	5 (2, 11)	5 (2, 13)
	post_p	NA (NA, NA)	0.61 (0.3, 0.89)	0.84 (0.46, 0.98)	0.16 (0.05, 0.36)	0.16 (0.05, 0.35)
	rate	0.056 (0.038, 0.083)	0.051 (0.026, 0.101)	0.037 (0.021, 0.067)	0.149 (0.089, 0.322)	0.157 (0.089, 0.345)
–+-	graduation	0	207	29	11	9
	futility	0	0	0	0	0
	max_n	0	1	40	8	4
	n	63 (51, 78)	22 (8, 58)	22 (7, 54)	22 (7, 55)	24 (8, 53)
	n_unique	58 (45, 72)	20 (8, 56)	21 (6, 52)	20 (6, 53)	23 (7, 50)
	post_p	NA (NA, NA)	0.45 (0.12, 0.89)	0.42 (0.1, 0.87)	0.43 (0.11, 0.86)	0.43 (0.11, 0.85)
	rate	0.141 (0.119, 0.167)	0.147 (0.115, 0.242)	0.149 (0.115, 0.258)	0.15 (0.116, 0.286)	0.147 (0.115, 0.265)
–++	graduation	0	283	145	16	14
	futility	0	0	0	0	0
	max_n	0	1	53	9	4
	n	48 (38, 57)	7 (3, 17)	42 (13, 53)	9 (4, 24)	8 (4, 22)
	n_unique	44 (34, 53)	6 (3, 16)	39 (12, 50)	7 (3, 22)	7 (3, 21)
	post_p	NA (NA, NA)	0.17 (0.06, 0.42)	1 (0.96, 1)	0.18 (0.05, 0.42)	0.16 (0.05, 0.41)
	rate	0.084 (0.065, 0.109)	0.153 (0.103, 0.319)	0.035 (0.025, 0.048)	0.149 (0.1, 0.27)	0.158 (0.103, 0.344)
-+–	graduation	0	294	79	225	205
	futility	0	0	0	0	0
	max_n	0	107	8	21	25
	n	20 (14, 27)	3 (0, 11)	5 (2, 10)	12 (5, 23)	14 (5, 23)
	n_unique	18 (13, 25)	3 (0, 10)	4 (2, 9)	12 (4, 22)	13 (4, 22)
	post_p	NA (NA, NA)	0.51 (0.26, 0.84)	0.25 (0.11, 0.47)	0.93 (0.64, 1)	0.94 (0.69, 1)
	rate	0.108 (0.076, 0.151)	0.078 (0.036, 0.188)	0.155 (0.093, 0.356)	0.037 (0.021, 0.066)	0.036 (0.02, 0.062)
-+-+	graduation	0	349	196	229	208
	futility	0	0	0	0	0
	max_n	0	106	24	22	25
	n	20 (14, 26)	3 (0, 9)	7 (2, 17)	12 (4, 23)	12 (4, 21)
	n_unique	18 (12, 24)	3 (0, 9)	7 (2, 16)	11 (3, 21)	11 (4, 21)
	post_p	NA (NA, NA)	0.37 (0.16, 0.65)	0.61 (0.3, 0.89)	0.78 (0.42, 0.96)	0.79 (0.43, 0.97)
	rate	0.074 (0.05, 0.105)	0.083 (0.042, 0.236)	0.047 (0.024, 0.107)	0.036 (0.019, 0.068)	0.036 (0.02, 0.066)
-++-	graduation	0	271	43	195	185
	futility	0	0	0	0	0
	max_n	0	1	40	7	4
	n	11 (7, 16)	3 (1, 7)	4 (1, 7)	8 (3, 14)	8 (3, 14)
	n_unique	10 (7, 15)	3 (1, 6)	3 (1, 7)	7 (2, 13)	7 (2, 13)
	post_p	NA (NA, NA)	0.35 (0.2, 0.56)	0.34 (0.19, 0.58)	0.9 (0.58, 0.98)	0.9 (0.63, 0.99)
	rate	0.145 (0.094, 0.23)	0.165 (0.089, 0.492)	0.166 (0.087, 0.491)	0.038 (0.016, 0.084)	0.036 (0.014, 0.07)
-+++	graduation	0	328	158	199	188
	futility	0	0	0	0	0
	max_n	0	1	53	8	4
	n	12 (7, 17)	3 (1, 6)	5 (1, 10)	7 (2, 14)	7 (3, 13)
	n_unique	11 (6, 15)	2 (1, 5)	4 (1, 9)	6 (2, 13)	7 (2, 12)
	post_p	NA (NA, NA)	0.32 (0.15, 0.45)	0.61 (0.35, 0.86)	0.75 (0.42, 0.94)	0.76 (0.44, 0.94)
	rate	0.091 (0.054, 0.161)	0.171 (0.08, 0.584)	0.048 (0.017, 0.141)	0.037 (0.014, 0.088)	0.034 (0.014, 0.078)
+—	graduation	0	17	5	3	2
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	20 (14, 27)	9 (3, 18)	10 (4, 20)	8 (3, 17)	8 (3, 17)
	n_unique	18 (12, 25)	8 (2, 17)	9 (4, 18)	7 (2, 16)	7 (2, 15)
	post_p	NA (NA, NA)	0.44 (0.17, 0.84)	0.45 (0.17, 0.85)	0.44 (0.18, 0.82)	0.42 (0.18, 0.82)
	rate	0.141 (0.099, 0.188)	0.156 (0.099, 0.352)	0.15 (0.1, 0.305)	0.158 (0.096, 0.424)	0.159 (0.097, 0.377)
+–+	graduation	0	160	132	8	8
	futility	0	0	0	0	0
	max_n	0	0	17	1	0
	n	17 (12, 23)	5 (2, 10)	14 (4, 22)	5 (2, 10)	5 (2, 11)
	n_unique	16 (11, 21)	4 (1, 9)	12 (4, 21)	4 (2, 9)	4 (2, 10)
	post_p	NA (NA, NA)	0.29 (0.13, 0.5)	0.94 (0.69, 1)	0.26 (0.13, 0.52)	0.27 (0.12, 0.5)
	rate	0.084 (0.054, 0.129)	0.154 (0.09, 0.397)	0.035 (0.018, 0.066)	0.158 (0.088, 0.432)	0.165 (0.096, 0.427)
+-+-	graduation	0	207	29	11	9
	futility	0	0	0	0	0
	max_n	0	1	40	8	4
	n	16 (10, 22)	5 (2, 14)	8 (3, 15)	7 (2, 15)	7 (2, 14)
	n_unique	14 (9, 20)	5 (1, 14)	7 (3, 13)	7 (2, 14)	6 (2, 13)
	post_p	NA (NA, NA)	0.45 (0.21, 0.81)	0.48 (0.19, 0.83)	0.49 (0.2, 0.82)	0.45 (0.2, 0.82)
	rate	0.143 (0.1, 0.209)	0.161 (0.098, 0.387)	0.149 (0.096, 0.337)	0.151 (0.091, 0.378)	0.152 (0.094, 0.416)
+-++	graduation	0	283	145	16	14
	futility	0	0	0	0	0
	max_n	0	1	53	9	4
	n	17 (11, 24)	4 (2, 9)	14 (3, 21)	5 (2, 11)	5 (2, 11)
	n_unique	15 (10, 22)	4 (1, 8)	13 (3, 20)	5 (2, 11)	5 (2, 11)
	post_p	NA (NA, NA)	0.29 (0.14, 0.51)	0.95 (0.73, 1)	0.27 (0.11, 0.5)	0.28 (0.12, 0.55)
	rate	0.086 (0.053, 0.133)	0.17 (0.089, 0.428)	0.034 (0.018, 0.064)	0.163 (0.094, 0.421)	0.155 (0.091, 0.432)
++–	graduation	0	125	21	194	183
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	11 (7, 17)	3 (1, 7)	4 (1, 6)	8 (2, 14)	8 (2, 14)
	n_unique	10 (6, 15)	3 (1, 6)	3 (1, 6)	7 (2, 13)	7 (2, 13)
	post_p	NA (NA, NA)	0.35 (0.2, 0.58)	0.35 (0.17, 0.58)	0.89 (0.6, 0.99)	0.89 (0.58, 0.99)
	rate	0.145 (0.094, 0.217)	0.163 (0.084, 0.427)	0.165 (0.08, 0.445)	0.034 (0.013, 0.081)	0.036 (0.015, 0.084)
++-+	graduation	0	230	146	198	187
	futility	0	0	0	0	0
	max_n	0	0	17	1	0
	n	11 (7, 17)	3 (1, 6)	4 (1, 10)	7 (2, 13)	7 (3, 14)
	n_unique	10 (6, 15)	3 (1, 6)	4 (1, 9)	6 (2, 12)	7 (2, 13)
	post_p	NA (NA, NA)	0.3 (0.16, 0.47)	0.55 (0.31, 0.82)	0.78 (0.48, 0.95)	0.79 (0.47, 0.95)
	rate	0.1 (0.061, 0.162)	0.155 (0.077, 0.467)	0.063 (0.029, 0.172)	0.035 (0.014, 0.082)	0.037 (0.016, 0.078)
+++-	graduation	0	271	43	195	185
	futility	0	0	0	0	0
	max_n	0	1	40	7	4
	n	11 (7, 17)	3 (1, 7)	3 (1, 7)	7 (3, 14)	8 (2, 14)
	n_unique	10 (6, 15)	3 (1, 6)	3 (1, 7)	7 (2, 13)	7 (2, 13)
	post_p	NA (NA, NA)	0.35 (0.19, 0.6)	0.34 (0.18, 0.6)	0.87 (0.58, 0.99)	0.88 (0.6, 0.99)
	rate	0.136 (0.091, 0.222)	0.162 (0.078, 0.49)	0.164 (0.077, 0.41)	0.037 (0.016, 0.08)	0.035 (0.016, 0.08)
++++	graduation	0	328	158	199	188
	futility	0	0	0	0	0
	max_n	0	1	53	8	4
	n	12 (7, 16)	3 (1, 6)	4 (1, 10)	7 (3, 14)	7 (3, 14)
	n_unique	10 (6, 15)	3 (0, 5)	4 (1, 9)	6 (2, 13)	7 (2, 13)
	post_p	NA (NA, NA)	0.3 (0.15, 0.46)	0.58 (0.32, 0.83)	0.78 (0.48, 0.96)	0.8 (0.47, 0.96)
	rate	0.1 (0.061, 0.166)	0.175 (0.085, 0.496)	0.059 (0.021, 0.141)	0.037 (0.018, 0.076)	0.035 (0.014, 0.081)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	ARSi	Taxane_CT	Platinum_CT	PARPi
all	count	13	5	3	2
	time_stop	5 (4, 7)	5 (5, 6)	6 (5, 7)	7 (6, 8)
	n_trt	29 (27, 53)	29 (26, 33)	29 (28, 35)	35 (28, 42)
	n_control	57 (46, 73)	59 (51, 73)	57 (55, 65)	78 (68, 88)
	post_p	0.92 (0.87, 0.98)	0.92 (0.87, 0.96)	0.99 (0.93, 0.99)	0.94 (0.9, 0.98)
	order	1 (1, 1)	1 (1, 1)	1 (1, 1)	1.5 (1.1, 1.9)
TP53- & AR-	count	223	2	6	1
	time_stop	9 (7, 16)	15 (13, 17)	14 (14, 19)	11 (11, 11)
	n_trt	31 (26, 63)	38 (31, 46)	30 (26, 32)	37 (37, 37)
	n_control	39 (28, 73)	72 (62, 82)	70 (48, 84)	56 (56, 56)
	post_p	0.94 (0.87, 1)	0.97 (0.96, 0.98)	0.94 (0.92, 0.98)	0.95 (0.95, 0.95)
	order	1 (1, 2)	1.5 (1.1, 1.9)	2 (1, 2)	2 (2, 2)
TP53+	count	1	24	6	6
	time_stop	7 (7, 7)	11 (9, 19)	12 (10, 16)	14 (10, 22)
	n_trt	25 (25, 25)	34 (28, 55)	30 (26, 40)	40 (26, 66)
	n_control	33 (33, 33)	53 (37, 84)	46 (43, 68)	70 (45, 112)
	post_p	0.98 (0.98, 0.98)	0.99 (0.93, 1)	0.99 (0.95, 0.99)	1 (0.97, 1)
	order	1 (1, 1)	1 (1, 2)	1.5 (1, 2.5)	1.5 (1, 3)
HRD+	count			191	181
	time_stop			25 (13, 35)	25 (14, 35)
	n_trt			53 (27, 91)	59 (28, 85)
	n_control			67 (33, 107)	75 (31, 102)
	post_p			1 (0.99, 1)	1 (0.99, 1)
	order			2 (1, 3)	2 (1, 3)
TEfus+	count		127	2	2
	time_stop		15 (10, 30)	10 (10, 11)	12 (12, 12)
	n_trt		39 (27, 106)	28 (27, 30)	26 (25, 27)
	n_control		56 (33, 134)	32 (28, 35)	46 (44, 47)
	post_p		1 (0.95, 1)	0.98 (0.98, 0.99)	0.92 (0.88, 0.95)
	order		2 (1, 3)	2 (1.2, 2.8)	1 (1, 1)

Futility:

signature	var	ARSi	Taxane_CT	Platinum_CT	PARPi
all	count	4
	time_stop	4 (3, 4)
	n_trt	28 (27, 34)
	n_control	38 (27, 45)
	post_p	0.19 (0.1, 0.23)
	order	1 (1, 1)
TP53- & AR-	count	2	60	34	31
	time_stop	7 (7, 7)	20 (12, 34)	17 (12, 25)	16 (13, 26)
	n_trt	27 (27, 27)	27 (25, 50)	31 (25, 52)	29 (25, 56)
	n_control	22 (20, 23)	98 (50, 163)	80 (51, 117)	76 (49, 120)
	post_p	0.21 (0.2, 0.21)	0.11 (0.03, 0.26)	0.09 (0.03, 0.21)	0.12 (0.05, 0.27)
	order	1 (1, 1)	1 (1, 2)	1 (1, 2)	1 (1, 2)
TP53+	count	189		2	1
	time_stop	20 (11, 32)		13 (11, 15)	11 (11, 11)
	n_trt	37 (26, 69)		26 (26, 26)	25 (25, 25)
	n_control	97 (47, 163)		68 (59, 77)	50 (50, 50)
	post_p	0.03 (0, 0.15)		0.11 (0.05, 0.17)	0.07 (0.07, 0.07)
	order	1 (1, 2)		1 (1, 1)	1 (1, 1)
HRD+	count	108	16
	time_stop	27 (20, 35)	26 (20, 32)
	n_trt	27 (25, 36)	28 (25, 44)
	n_control	78 (51, 107)	68 (47, 100)
	post_p	0.08 (0.01, 0.21)	0.16 (0.09, 0.22)
	order	2 (1, 3)	1.5 (1, 3)
TEfus+	count	143		3	4
	time_stop	23 (16, 32)		15 (13, 20)	16 (12, 21)
	n_trt	32 (25, 47)		31 (28, 37)	28 (28, 33)
	n_control	90 (52, 141)		59 (41, 66)	54 (34, 77)
	post_p	0.04 (0.01, 0.15)		0.28 (0.18, 0.28)	0.1 (0.04, 0.23)
	order	1 (1, 3)		1 (1, 1.8)	1 (1, 1.7)

By subgroup combinations

Graduation:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	ARSi	count	13	13	13	13	13	13	13	13	13	13	13	13	13	13	13	13
		time	5 (4, 7)	5 (4, 7)	5 (4, 7)	5 (4, 7)	5 (4, 7)	5 (4, 7)	5 (4, 7)	5 (4, 7)	5 (4, 7)	5 (4, 7)	5 (4, 7)	5 (4, 7)	5 (4, 7)	5 (4, 7)	5 (4, 7)	5 (4, 7)
		n	16 (12, 27)	2 (0, 4)	6 (3, 8)	2 (0, 7)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	2 (0, 2)	1 (0, 2)	1 (0, 3)	0 (0, 3)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 2)
		post_p	0.68 (0.65, 0.87)	0.52 (0.51, 0.55)	0.58 (0.54, 0.77)	0.54 (0.51, 0.6)	0.53 (0.51, 0.54)	0.53 (0.51, 0.55)	0.51 (0.51, 0.51)	0.51 (0.51, 0.53)	0.54 (0.51, 0.66)	0.51 (0.5, 0.51)	0.52 (0.5, 0.61)	0.54 (0.52, 0.57)	NA (NA, NA)	0.54 (0.54, 0.54)	0.54 (0.52, 0.57)	0.55 (0.54, 0.56)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.023 (0, 0.049)	0 (0, 0.069)	0.067 (0, 0.099)	0 (0, 0.09)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0.151)	0 (0, 0.284)	0 (0, 0.048)	0 (0, 0.054)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
	Taxane_CT	count	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5
		time	5 (5, 6)	5 (5, 6)	5 (5, 6)	5 (5, 6)	5 (5, 6)	5 (5, 6)	5 (5, 6)	5 (5, 6)	5 (5, 6)	5 (5, 6)	5 (5, 6)	5 (5, 6)	5 (5, 6)	5 (5, 6)	5 (5, 6)	5 (5, 6)
		n	4 (2, 7)	2 (0, 4)	2 (1, 7)	4 (4, 7)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 1)	5 (4, 6)	3 (1, 4)	2 (1, 4)	3 (1, 4)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 1)
		post_p	0.56 (0.54, 0.65)	0.56 (0.52, 0.61)	0.56 (0.53, 0.67)	0.56 (0.54, 0.6)	0.54 (0.54, 0.54)	NA (NA, NA)	NA (NA, NA)	0.52 (0.52, 0.52)	0.58 (0.54, 0.65)	0.54 (0.51, 0.56)	0.53 (0.53, 0.55)	0.59 (0.54, 0.63)	NA (NA, NA)	NA (NA, NA)	0.56 (0.52, 0.6)	NA (NA, NA)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0 (0, 0.024)	0 (0, 0)	0 (0, 0.059)	0.054 (0, 0.07)	0 (0, 0)	NA (NA, NA)	7.902 (7.902, 7.902)	0 (0, 0)	0.056 (0.017, 0.078)	0 (0, 0.054)	0 (0, 0.119)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)
	Platinum_CT	count	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3
		time	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)
		n	2 (2, 5)	1 (1, 2)	8 (6, 9)	1 (1, 2)	2 (1, 3)	2 (0, 4)	0 (0, 3)	2 (0, 3)	0 (0, 1)	1 (0, 1)	0 (0, 1)	1 (0, 1)	2 (0, 4)	1 (1, 2)	2 (1, 3)	3 (3, 5)
		post_p	0.54 (0.54, 0.65)	0.54 (0.52, 0.56)	0.68 (0.54, 0.73)	0.52 (0.51, 0.53)	0.54 (0.53, 0.59)	0.51 (0.51, 0.52)	0.56 (0.56, 0.56)	0.58 (0.58, 0.58)	0.52 (0.52, 0.52)	0.56 (0.54, 0.58)	0.57 (0.57, 0.57)	0.53 (0.51, 0.54)	0.51 (0.51, 0.51)	0.52 (0.51, 0.53)	0.5 (0.5, 0.5)	0.54 (0.51, 0.57)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0 (0, 0.053)	0 (0, 0)	0.127 (0.025, 0.167)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.066 (0.066, 0.066)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
	PARPi	count	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
		time	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)
		n	6 (6, 7)	0 (0, 1)	7 (5, 9)	2 (0, 3)	4 (3, 4)	4 (2, 6)	2 (1, 3)	1 (0, 2)	2 (1, 2)	0 (0, 0)	0 (0, 1)	0 (0, 1)	4 (3, 4)	0 (0, 1)	0 (0, 1)	2 (0, 4)
		post_p	0.63 (0.54, 0.71)	0.52 (0.52, 0.52)	0.53 (0.51, 0.54)	0.54 (0.54, 0.54)	0.61 (0.52, 0.69)	0.54 (0.52, 0.56)	0.52 (0.52, 0.52)	0.54 (0.54, 0.54)	0.53 (0.52, 0.54)	NA (NA, NA)	0.51 (0.51, 0.51)	0.51 (0.51, 0.51)	0.52 (0.52, 0.53)	0.56 (0.56, 0.56)	0.52 (0.52, 0.52)	0.53 (0.53, 0.53)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.071 (0.057, 0.086)	0 (0, 0)	0.175 (0.155, 0.194)	0.113 (0.113, 0.113)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53- & AR-	ARSi	count	223	223			223	223
		time	9 (7, 16)	9 (7, 16)			9 (7, 16)	9 (7, 16)
		n	26 (20, 50)	3 (2, 6)			2 (0, 4)	1 (0, 4)
		post_p	0.91 (0.79, 1)	0.55 (0.51, 0.71)			0.54 (0.51, 0.65)	0.53 (0.51, 0.6)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.032 (0.012, 0.051)	0 (0, 0.071)			0 (0, 0.068)	0 (0, 0.05)
	Taxane_CT	count	2	2			2	2
		time	15 (13, 17)	15 (13, 17)			15 (13, 17)	15 (13, 17)
		n	18 (12, 23)	11 (9, 13)			4 (2, 6)	6 (3, 9)
		post_p	0.72 (0.71, 0.74)	0.9 (0.85, 0.96)			0.53 (0.53, 0.53)	0.67 (0.62, 0.72)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.069 (0.069, 0.07)	0.01 (0.002, 0.018)			0.084 (0.074, 0.094)	0.009 (0.002, 0.015)
	Platinum_CT	count	6	6			6	6
		time	14 (14, 19)	14 (14, 19)			14 (14, 19)	14 (14, 19)
		n	13 (10, 16)	4 (2, 6)			9 (3, 12)	4 (2, 8)
		post_p	0.78 (0.77, 0.85)	0.6 (0.51, 0.75)			0.71 (0.57, 0.73)	0.54 (0.51, 0.69)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.058 (0.053, 0.077)	0 (0, 0.052)			0.04 (0.01, 0.053)	0.013 (0, 0.039)
	PARPi	count	1	1			1	1
		time	11 (11, 11)	11 (11, 11)			11 (11, 11)	11 (11, 11)
		n	31 (31, 31)	1 (1, 1)			3 (3, 3)	2 (2, 2)
		post_p	0.93 (0.93, 0.93)	0.54 (0.54, 0.54)			0.58 (0.58, 0.58)	0.59 (0.59, 0.59)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.058 (0.058, 0.058)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TP53+	ARSi	count			1	1			1	1			1	1			1	1
		time			7 (7, 7)	7 (7, 7)			7 (7, 7)	7 (7, 7)			7 (7, 7)	7 (7, 7)			7 (7, 7)	7 (7, 7)
		n			15 (15, 15)	6 (6, 6)			0 (0, 0)	0 (0, 0)			1 (1, 1)	3 (3, 3)			0 (0, 0)	0 (0, 0)
		post_p			0.81 (0.81, 0.81)	0.74 (0.74, 0.74)			NA (NA, NA)	NA (NA, NA)			0.54 (0.54, 0.54)	0.61 (0.61, 0.61)			NA (NA, NA)	NA (NA, NA)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.038 (0.038, 0.038)	0 (0, 0)			NA (NA, NA)	NA (NA, NA)			0 (0, 0)	0 (0, 0)			NA (NA, NA)	NA (NA, NA)
	Taxane_CT	count			24	24			24	24			24	24			24	24
		time			11 (9, 19)	11 (9, 19)			11 (9, 19)	11 (9, 19)			11 (9, 19)	11 (9, 19)			11 (9, 19)	11 (9, 19)
		n			14 (9, 21)	13 (8, 20)			1 (0, 2)	1 (0, 2)			4 (0, 5)	4 (1, 9)			1 (0, 5)	1 (0, 3)
		post_p			0.77 (0.72, 0.86)	0.86 (0.76, 0.97)			0.54 (0.51, 0.59)	0.55 (0.51, 0.6)			0.57 (0.54, 0.73)	0.7 (0.54, 0.84)			0.54 (0.51, 0.56)	0.57 (0.52, 0.61)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.082 (0.023, 0.136)	0.026 (0, 0.058)			0 (0, 0.096)	0 (0, 0.021)			0.077 (0, 0.145)	0.024 (0, 0.074)			0 (0, 0.105)	0 (0, 0.063)
	Platinum_CT	count			6	6			6	6			6	6			6	6
		time			12 (10, 16)	12 (10, 16)			12 (10, 16)	12 (10, 16)			12 (10, 16)	12 (10, 16)			12 (10, 16)	12 (10, 16)
		n			12 (9, 16)	4 (2, 5)			4 (1, 6)	2 (0, 4)			4 (2, 6)	1 (0, 2)			3 (2, 4)	3 (0, 4)
		post_p			0.84 (0.79, 0.92)	0.55 (0.54, 0.64)			0.59 (0.54, 0.74)	0.56 (0.54, 0.58)			0.57 (0.55, 0.78)	0.54 (0.53, 0.56)			0.56 (0.51, 0.79)	0.54 (0.52, 0.64)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.075 (0.042, 0.101)	0.027 (0, 0.101)			0 (0, 0.083)	0 (0, 0.027)			0.061 (0, 0.106)	0 (0, 0.07)			0 (0, 0.043)	0 (0, 0.038)
	PARPi	count			6	6			6	6			6	6			6	6
		time			14 (10, 22)	14 (10, 22)			14 (10, 22)	14 (10, 22)			14 (10, 22)	14 (10, 22)			14 (10, 22)	14 (10, 22)
		n			16 (10, 32)	4 (1, 12)			2 (2, 4)	3 (2, 6)			3 (1, 8)	2 (0, 3)			4 (2, 6)	4 (1, 4)
		post_p			0.84 (0.75, 0.96)	0.55 (0.5, 0.8)			0.62 (0.54, 0.89)	0.59 (0.53, 0.76)			0.63 (0.54, 0.74)	0.57 (0.54, 0.65)			0.66 (0.55, 0.8)	0.6 (0.53, 0.76)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.089 (0.024, 0.097)	0.023 (0, 0.089)			0 (0, 0.019)	0.009 (0, 0.058)			0.015 (0, 0.108)	0.036 (0, 0.079)			0.01 (0, 0.045)	0.013 (0, 0.041)
HRD+	Platinum_CT	count					191	191	191	191					191	191	191	191
		time					25 (13, 35)	25 (13, 35)	25 (13, 35)	25 (13, 35)					25 (13, 35)	25 (13, 35)	25 (13, 35)	25 (13, 35)
		n					10 (4, 19)	9 (3, 19)	6 (2, 11)	5 (2, 11)					5 (2, 12)	5 (2, 11)	5 (2, 11)	5 (2, 11)
		post_p					0.8 (0.58, 0.98)	0.74 (0.53, 0.91)	0.75 (0.56, 0.96)	0.7 (0.52, 0.88)					0.74 (0.55, 0.94)	0.69 (0.53, 0.9)	0.73 (0.53, 0.94)	0.7 (0.53, 0.88)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.03 (0, 0.06)	0.029 (0, 0.052)	0.032 (0, 0.083)	0.028 (0, 0.055)					0.028 (0, 0.061)	0.024 (0, 0.054)	0.032 (0, 0.07)	0.029 (0, 0.058)
	PARPi	count					181	181	181	181					181	181	181	181
		time					25 (14, 35)	25 (14, 35)	25 (14, 35)	25 (14, 35)					25 (14, 35)	25 (14, 35)	25 (14, 35)	25 (14, 35)
		n					11 (4, 19)	10 (3, 18)	5 (2, 11)	5 (2, 11)					5 (2, 12)	5 (2, 12)	5 (2, 11)	5 (2, 11)
		post_p					0.84 (0.6, 0.99)	0.75 (0.56, 0.95)	0.76 (0.55, 0.97)	0.73 (0.53, 0.89)					0.74 (0.55, 0.94)	0.72 (0.53, 0.91)	0.78 (0.56, 0.96)	0.71 (0.52, 0.92)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.028 (0, 0.054)	0.026 (0, 0.046)	0.029 (0, 0.063)	0.023 (0, 0.052)					0.028 (0, 0.068)	0.03 (0, 0.065)	0.026 (0, 0.067)	0.03 (0, 0.063)
TEfus+	Taxane_CT	count		127		127		127		127		127		127		127		127
		time		15 (10, 30)		15 (10, 30)		15 (10, 30)		15 (10, 30)		15 (10, 30)		15 (10, 30)		15 (10, 30)		15 (10, 30)
		n		5 (2, 17)		16 (10, 39)		3 (1, 12)		2 (0, 5)		5 (2, 13)		5 (2, 13)		2 (0, 5)		2 (0, 5)
		post_p		0.7 (0.54, 0.91)		0.92 (0.74, 1)		0.58 (0.52, 0.81)		0.56 (0.51, 0.78)		0.71 (0.55, 0.96)		0.72 (0.54, 0.96)		0.55 (0.51, 0.73)		0.56 (0.51, 0.75)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0.02 (0, 0.051)		0.033 (0.01, 0.055)		0 (0, 0.052)		0 (0, 0.057)		0.03 (0, 0.064)		0.025 (0, 0.084)		0 (0, 0.087)		0 (0, 0.099)
	Platinum_CT	count		2		2		2		2		2		2		2		2
		time		10 (10, 11)		10 (10, 11)		10 (10, 11)		10 (10, 11)		10 (10, 11)		10 (10, 11)		10 (10, 11)		10 (10, 11)
		n		3 (2, 4)		7 (5, 9)		3 (2, 4)		2 (1, 3)		2 (1, 3)		4 (3, 4)		4 (3, 4)		4 (4, 5)
		post_p		0.6 (0.57, 0.64)		0.71 (0.54, 0.88)		0.58 (0.54, 0.61)		0.52 (0.51, 0.53)		0.54 (0.51, 0.57)		0.55 (0.52, 0.58)		0.57 (0.56, 0.59)		0.59 (0.59, 0.59)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0 (0, 0)		0.067 (0.013, 0.12)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.087 (0.072, 0.102)		0 (0, 0)		0 (0, 0)
	PARPi	count		2		2		2		2		2		2		2		2
		time		12 (12, 12)		12 (12, 12)		12 (12, 12)		12 (12, 12)		12 (12, 12)		12 (12, 12)		12 (12, 12)		12 (12, 12)
		n		2 (0, 3)		6 (2, 9)		7 (5, 9)		2 (2, 3)		2 (1, 3)		0 (0, 1)		4 (3, 4)		4 (3, 4)
		post_p		0.52 (0.52, 0.52)		0.69 (0.56, 0.83)		0.7 (0.62, 0.78)		0.55 (0.53, 0.57)		0.52 (0.51, 0.54)		0.58 (0.58, 0.58)		0.6 (0.6, 0.61)		0.55 (0.53, 0.57)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.103 (0.103, 0.103)		0.02 (0.004, 0.036)		0.028 (0.006, 0.05)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.017 (0.003, 0.03)		0.016 (0.003, 0.029)

Futility:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	ARSi	count	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4
		time	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)
		n	15 (15, 16)	2 (1, 2)	6 (4, 9)	4 (1, 6)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)	1 (0, 1)	0 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 1)
		post_p	0.47 (0.42, 0.5)	0.43 (0.43, 0.48)	0.44 (0.39, 0.48)	0.41 (0.39, 0.47)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.46 (0.44, 0.48)	0.46 (0.43, 0.46)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.5 (0.5, 0.5)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.087 (0.069, 0.099)	0.265 (0.053, 0.265)	0.194 (0.144, 0.265)	0.181 (0.039, 0.273)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.725 (0.145, 1.305)	2.644 (1.242, 8.745)	0.072 (0.014, 0.129)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)
TP53- & AR-		count	2	2			2	2
		time	7 (7, 7)	7 (7, 7)			7 (7, 7)	7 (7, 7)
		n	20 (19, 20)	6 (4, 7)			0 (0, 0)	2 (1, 3)
		post_p	0.43 (0.41, 0.46)	0.41 (0.4, 0.43)			NA (NA, NA)	0.44 (0.43, 0.44)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.101 (0.092, 0.109)	0.104 (0.083, 0.124)			NA (NA, NA)	0.468 (0.41, 0.527)
	Taxane_CT	count	60	60			60	60
		time	20 (12, 34)	20 (12, 34)			20 (12, 34)	20 (12, 34)
		n	14 (9, 29)	6 (4, 14)			4 (1, 7)	4 (2, 7)
		post_p	0.14 (0.02, 0.42)	0.44 (0.32, 0.49)			0.32 (0.18, 0.46)	0.42 (0.28, 0.49)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.134 (0.108, 0.205)	0.076 (0.052, 0.135)			0.157 (0.095, 0.403)	0.094 (0.055, 0.24)
	Platinum_CT	count	34	34			34	34
		time	17 (12, 25)	17 (12, 25)			17 (12, 25)	17 (12, 25)
		n	16 (9, 36)	5 (2, 8)			5 (3, 9)	5 (3, 10)
		post_p	0.1 (0.01, 0.27)	0.38 (0.2, 0.48)			0.46 (0.35, 0.49)	0.44 (0.3, 0.48)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.145 (0.1, 0.222)	0.109 (0.067, 0.344)			0.077 (0.054, 0.117)	0.068 (0.041, 0.153)
	PARPi	count	31	31			31	31
		time	16 (13, 26)	16 (13, 26)			16 (13, 26)	16 (13, 26)
		n	15 (10, 40)	4 (2, 7)			4 (1, 8)	5 (2, 10)
		post_p	0.16 (0.06, 0.35)	0.32 (0.16, 0.45)			0.42 (0.29, 0.49)	0.44 (0.34, 0.48)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.138 (0.089, 0.223)	0.198 (0.085, 0.616)			0.093 (0.051, 0.246)	0.057 (0.034, 0.255)
TP53+	ARSi	count			189	189			189	189			189	189			189	189
		time			20 (11, 32)	20 (11, 32)			20 (11, 32)	20 (11, 32)			20 (11, 32)	20 (11, 32)			20 (11, 32)	20 (11, 32)
		n			13 (7, 36)	6 (3, 15)			2 (1, 5)	2 (0, 4)			3 (1, 9)	4 (1, 7)			2 (1, 5)	2 (0, 5)
		post_p			0.3 (0.1, 0.48)	0.23 (0.1, 0.44)			0.4 (0.22, 0.48)	0.36 (0.23, 0.47)			0.4 (0.21, 0.48)	0.37 (0.19, 0.48)			0.39 (0.23, 0.47)	0.37 (0.17, 0.48)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.175 (0.129, 0.272)	0.162 (0.102, 0.342)			0.181 (0.098, 0.815)	0.193 (0.087, 0.747)			0.212 (0.133, 0.442)	0.181 (0.093, 0.533)			0.188 (0.084, 0.62)	0.178 (0.074, 0.582)
	Platinum_CT	count			2	2			2	2			2	2			2	2
		time			13 (11, 15)	13 (11, 15)			13 (11, 15)	13 (11, 15)			13 (11, 15)	13 (11, 15)			13 (11, 15)	13 (11, 15)
		n			8 (7, 8)	5 (3, 7)			2 (1, 3)	2 (1, 3)			2 (1, 3)	3 (2, 4)			1 (0, 2)	4 (3, 4)
		post_p			0.34 (0.31, 0.37)	0.18 (0.1, 0.27)			0.46 (0.43, 0.49)	0.39 (0.36, 0.43)			0.26 (0.16, 0.35)	0.4 (0.35, 0.46)			0.48 (0.48, 0.48)	0.42 (0.39, 0.45)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.194 (0.181, 0.208)	0.346 (0.29, 0.401)			0.207 (0.1, 0.314)	0.175 (0.157, 0.193)			0.539 (0.519, 0.559)	0.269 (0.168, 0.37)			0.08 (0.08, 0.08)	0.077 (0.059, 0.096)
	PARPi	count			1	1			1	1			1	1			1	1
		time			11 (11, 11)	11 (11, 11)			11 (11, 11)	11 (11, 11)			11 (11, 11)	11 (11, 11)			11 (11, 11)	11 (11, 11)
		n			5 (5, 5)	8 (8, 8)			0 (0, 0)	4 (4, 4)			2 (2, 2)	1 (1, 1)			0 (0, 0)	5 (5, 5)
		post_p			0.27 (0.27, 0.27)	0.23 (0.23, 0.23)			NA (NA, NA)	0.4 (0.4, 0.4)			0.33 (0.33, 0.33)	0.38 (0.38, 0.38)			NA (NA, NA)	0.43 (0.43, 0.43)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.241 (0.241, 0.241)	0.144 (0.144, 0.144)			NA (NA, NA)	0.092 (0.092, 0.092)			0.251 (0.251, 0.251)	0.223 (0.223, 0.223)			NA (NA, NA)	0.144 (0.144, 0.144)
HRD+	ARSi	count					108	108	108	108					108	108	108	108
		time					27 (20, 35)	27 (20, 35)	27 (20, 35)	27 (20, 35)					27 (20, 35)	27 (20, 35)	27 (20, 35)	27 (20, 35)
		n					4 (0, 9)	4 (1, 9)	3 (1, 7)	3 (1, 6)					3 (1, 7)	3 (1, 5)	3 (1, 6)	3 (1, 6)
		post_p					0.39 (0.19, 0.48)	0.36 (0.17, 0.46)	0.36 (0.23, 0.47)	0.34 (0.18, 0.47)					0.35 (0.18, 0.48)	0.34 (0.21, 0.46)	0.35 (0.19, 0.47)	0.34 (0.15, 0.46)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.117 (0.074, 0.254)	0.102 (0.058, 0.262)	0.168 (0.104, 0.58)	0.166 (0.086, 0.359)					0.176 (0.102, 0.448)	0.164 (0.086, 0.485)	0.157 (0.093, 0.432)	0.173 (0.079, 0.453)
	Taxane_CT	count					16	16	16	16					16	16	16	16
		time					26 (20, 32)	26 (20, 32)	26 (20, 32)	26 (20, 32)					26 (20, 32)	26 (20, 32)	26 (20, 32)	26 (20, 32)
		n					4 (3, 8)	6 (2, 11)	3 (2, 6)	2 (0, 4)					3 (2, 5)	3 (1, 7)	4 (1, 7)	3 (0, 6)
		post_p					0.32 (0.19, 0.43)	0.4 (0.29, 0.48)	0.34 (0.19, 0.46)	0.41 (0.28, 0.47)					0.32 (0.2, 0.44)	0.41 (0.32, 0.48)	0.37 (0.25, 0.43)	0.46 (0.29, 0.49)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.146 (0.103, 0.244)	0.066 (0.045, 0.094)	0.178 (0.098, 0.717)	0.107 (0.074, 0.444)					0.264 (0.096, 0.658)	0.112 (0.068, 0.406)	0.139 (0.096, 0.522)	0.069 (0.047, 0.119)
TEfus+	ARSi	count		143		143		143		143		143		143		143		143
		time		23 (16, 32)		23 (16, 32)		23 (16, 32)		23 (16, 32)		23 (16, 32)		23 (16, 32)		23 (16, 32)		23 (16, 32)
		n		6 (3, 11)		7 (3, 13)		3 (0, 7)		2 (1, 5)		4 (1, 8)		4 (1, 7)		3 (1, 5)		3 (1, 5)
		post_p		0.43 (0.25, 0.49)		0.23 (0.09, 0.46)		0.39 (0.21, 0.49)		0.36 (0.2, 0.45)		0.34 (0.2, 0.48)		0.34 (0.21, 0.48)		0.37 (0.21, 0.47)		0.37 (0.19, 0.46)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.073 (0.047, 0.136)		0.153 (0.091, 0.322)		0.092 (0.054, 0.287)		0.181 (0.082, 0.614)		0.15 (0.095, 0.456)		0.176 (0.09, 0.413)		0.181 (0.077, 0.405)		0.165 (0.074, 0.489)
	Platinum_CT	count		3		3		3		3		3		3		3		3
		time		15 (13, 20)		15 (13, 20)		15 (13, 20)		15 (13, 20)		15 (13, 20)		15 (13, 20)		15 (13, 20)		15 (13, 20)
		n		3 (1, 4)		9 (7, 11)		8 (6, 8)		1 (0, 3)		3 (1, 4)		1 (0, 2)		3 (3, 7)		3 (3, 5)
		post_p		0.22 (0.11, 0.4)		0.34 (0.28, 0.43)		0.45 (0.44, 0.47)		0.47 (0.46, 0.47)		0.44 (0.24, 0.45)		0.36 (0.31, 0.42)		0.43 (0.41, 0.48)		0.45 (0.43, 0.49)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.499 (0.213, 0.685)		0.117 (0.117, 0.206)		0.042 (0.042, 0.043)		0.068 (0.066, 0.07)		0.246 (0.143, 0.254)		0.335 (0.305, 0.366)		0.039 (0.035, 0.04)		0.091 (0.068, 0.109)
	PARPi	count		4		4		4		4		4		4		4		4
		time		16 (12, 21)		16 (12, 21)		16 (12, 21)		16 (12, 21)		16 (12, 21)		16 (12, 21)		16 (12, 21)		16 (12, 21)
		n		4 (2, 6)		3 (2, 7)		6 (5, 8)		4 (3, 7)		2 (1, 4)		2 (1, 4)		2 (2, 4)		3 (1, 5)
		post_p		0.34 (0.1, 0.43)		0.24 (0.14, 0.26)		0.4 (0.35, 0.48)		0.44 (0.36, 0.47)		0.41 (0.35, 0.48)		0.21 (0.19, 0.33)		0.38 (0.34, 0.48)		0.42 (0.23, 0.46)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.173 (0.1, 0.238)		0.296 (0.161, 0.782)		0.068 (0.046, 0.087)		0.049 (0.042, 0.08)		0.131 (0.064, 0.348)		0.195 (0.166, 0.264)		0.188 (0.051, 0.715)		0.111 (0.075, 0.381)