Simulation scenario 6, CR phase

Setting description

Platinum_CT and PARPi more effective in the HRD+ biomarker signature

Simulations setting

Survival curves (by signature)

PFS distributions (by signature)

Treatment effects (by signature)

signature	var	Other	ARSi	Taxane_CT	Platinum_CT	PARPi
all	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.091, shape = 1.05	scale = 0.091, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 10.8, median = 7.7	mean = 10.8, median = 7.7
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.23, hr = 0.81	af = 1.23, hr = 0.81
TP53- & AR-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.093, shape = 1.05	scale = 0.093, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 10.5, median = 7.6	mean = 10.5, median = 7.6
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.2, hr = 0.83	af = 1.2, hr = 0.83
TP53+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.092, shape = 1.05	scale = 0.092, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 10.7, median = 7.7	mean = 10.7, median = 7.7
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.21, hr = 0.82	af = 1.21, hr = 0.82
HRD+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
TEfus+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.084, shape = 1.05	scale = 0.084, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 11.7, median = 8.4	mean = 11.7, median = 8.4
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.33, hr = 0.74	af = 1.33, hr = 0.74

Survival curves (by subgroup)

PFS distributions (by subgroup)

Treatment effects (by subgroup)

subtype	var	Other	ARSi	Taxane_CT	Platinum_CT	PARPi
—-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
-+-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
-++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
-+++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
+—	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+–+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
++-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
+++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
++++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31

Errors and power

graduation (counts and proportions):

ARSi Taxane_CT Platinum_CT PARPi all 6 3 19 15 TP53- & AR- 30 13 116 121 TP53+ 8 3 21 20 HRD+ 0 0 247 241 TEfus+ 0 2 18 27

ARSi Taxane_CT Platinum_CT PARPi all 0.012 0.006 0.038 0.030 TP53- & AR- 0.060 0.026 0.232 0.242 TP53+ 0.016 0.006 0.042 0.040 HRD+ 0.000 0.000 0.494 0.482 TEfus+ 0.000 0.004 0.036 0.054

futility (counts and proportions):

ARSi Taxane_CT Platinum_CT PARPi all 14 6 0 0 TP53- & AR- 243 196 5 5 TP53+ 79 63 0 0 HRD+ 107 123 0 0 TEfus+ 62 76 0 0

ARSi Taxane_CT Platinum_CT PARPi all 0.028 0.012 0.00 0.00 TP53- & AR- 0.486 0.392 0.01 0.01 TP53+ 0.158 0.126 0.00 0.00 HRD+ 0.214 0.246 0.00 0.00 TEfus+ 0.124 0.152 0.00 0.00

max sample size (counts and proportions):

ARSi Taxane_CT Platinum_CT PARPi all 0 0 0 0 TP53- & AR- 9 11 26 20 TP53+ 9 7 9 11 HRD+ 0 0 0 0 TEfus+ 1 0 0 1

ARSi Taxane_CT Platinum_CT PARPi all 0.000 0.000 0.000 0.000 TP53- & AR- 0.018 0.022 0.052 0.040 TP53+ 0.018 0.014 0.018 0.022 HRD+ 0.000 0.000 0.000 0.000 TEfus+ 0.002 0.000 0.000 0.002

Errors & power

The overall error was 0.34.
The corresponding errors separate for the different treatments were:

       ARSi   Taxane_CT Platinum_CT       PARPi 
      0.084       0.042       0.122       0.148 

The overall power was 0.718.
The corresponding power separate for the different treatments were:

       ARSi   Taxane_CT Platinum_CT       PARPi 
      0.000       0.000       0.494       0.482 

Median results at the end of the trial

By signature:

signature	var	Control	ARSi	Taxane_CT	Platinum_CT	PARPi
all	graduation	0	6	3	19	15
	futility	0	14	6	0	0
	max_n	0	0	0	0	0
	n	417 (384, 454)	168 (105, 242)	180 (125, 250)	197 (123, 264)	195 (132, 268)
	n_unique	382 (353, 415)	154 (99, 228)	166 (114, 234)	180 (111, 246)	181 (120, 252)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	8 (4, 29)	6 (4, 29)	7 (6, 27)	8 (5, 33)
	post_p	NA (NA, NA)	0.46 (0.08, 0.85)	0.46 (0.09, 0.86)	1 (1, 1)	1 (1, 1)
	rate	0.112 (0.105, 0.12)	0.113 (0.102, 0.129)	0.112 (0.102, 0.126)	0.073 (0.062, 0.084)	0.072 (0.062, 0.083)
TP53- & AR-	graduation	0	30	13	116	121
	futility	0	243	196	5	5
	max_n	0	9	11	26	20
	n	176 (151, 197)	54 (26, 125)	55 (26, 122)	70 (29, 132)	69 (33, 132)
	n_unique	163 (138, 184)	51 (25, 117)	52 (24, 116)	64 (26, 125)	63 (30, 125)
	time_trial	36 (36, 36)	29 (9, 36)	36 (14, 36)	36 (17, 36)	36 (17, 36)
	time_stop	NA (NA, NA)	14 (7, 28)	19 (12, 32)	18 (12, 31)	20 (12, 33)
	post_p	NA (NA, NA)	0.38 (0.08, 0.85)	0.41 (0.08, 0.83)	0.99 (0.84, 1)	0.99 (0.8, 1)
	rate	0.112 (0.101, 0.126)	0.116 (0.096, 0.146)	0.116 (0.097, 0.142)	0.074 (0.055, 0.093)	0.074 (0.054, 0.096)
TP53+	graduation	0	8	3	21	20
	futility	0	79	63	0	0
	max_n	0	9	7	9	11
	n	184 (162, 210)	81 (38, 122)	87 (49, 118)	88 (53, 125)	91 (54, 126)
	n_unique	168 (147, 191)	75 (34, 111)	81 (44, 110)	81 (49, 117)	84 (50, 117)
	time_trial	36 (36, 36)	36 (22, 36)	36 (30, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	18 (10, 33)	18 (9, 32)	14 (10, 23)	13 (10, 25)
	post_p	NA (NA, NA)	0.43 (0.07, 0.86)	0.42 (0.1, 0.86)	0.99 (0.86, 1)	1 (0.89, 1)
	rate	0.113 (0.101, 0.125)	0.114 (0.098, 0.141)	0.113 (0.098, 0.134)	0.076 (0.06, 0.093)	0.074 (0.06, 0.09)
HRD+	graduation	0	0	0	247	241
	futility	0	107	123	0	0
	max_n	0	0	0	0	0
	n	111 (94, 130)	34 (23, 55)	36 (24, 58)	72 (28, 99)	72 (33, 101)
	n_unique	101 (85, 118)	31 (20, 51)	33 (22, 53)	66 (26, 92)	66 (30, 93)
	time_trial	36 (36, 36)	36 (28, 36)	36 (27, 36)	36 (16, 36)	36 (18, 36)
	time_stop	NA (NA, NA)	29 (23, 34)	28 (20, 34)	23 (13, 34)	26 (13, 35)
	post_p	NA (NA, NA)	0.36 (0.06, 0.79)	0.35 (0.06, 0.72)	1 (1, 1)	1 (1, 1)
	rate	0.112 (0.099, 0.127)	0.112 (0.089, 0.148)	0.114 (0.093, 0.149)	0.036 (0.028, 0.045)	0.036 (0.028, 0.044)
TEfus+	graduation	0	0	2	18	27
	futility	0	62	76	0	0
	max_n	0	1	0	0	1
	n	152 (132, 172)	60 (33, 90)	70 (38, 96)	75 (43, 105)	78 (45, 106)
	n_unique	138 (119, 157)	55 (30, 82)	64 (35, 90)	68 (39, 97)	72 (41, 97)
	time_trial	36 (36, 36)	36 (31, 36)	36 (26, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	22 (16, 34)	22 (12, 31)	17 (12, 28)	16 (11, 30)
	post_p	NA (NA, NA)	0.4 (0.09, 0.8)	0.41 (0.07, 0.82)	1 (0.93, 1)	1 (0.95, 1)
	rate	0.112 (0.099, 0.126)	0.115 (0.096, 0.14)	0.113 (0.097, 0.141)	0.065 (0.052, 0.08)	0.065 (0.051, 0.08)

By subgroup combinations:

subtype	var	Control	ARSi	Taxane_CT	Platinum_CT	PARPi
—-	graduation	0	283	217	138	138
	futility	0	0	0	0	0
	max_n	0	9	11	26	20
	n	114 (94, 132)	31 (17, 98)	34 (10, 90)	33 (10, 89)	34 (12, 90)
	n_unique	106 (85, 123)	30 (16, 91)	32 (9, 85)	30 (9, 86)	31 (10, 85)
	post_p	NA (NA, NA)	0.45 (0.09, 0.87)	0.43 (0.1, 0.87)	0.49 (0.09, 0.89)	0.47 (0.11, 0.87)
	rate	0.113 (0.099, 0.128)	0.117 (0.094, 0.16)	0.119 (0.096, 0.18)	0.115 (0.09, 0.179)	0.115 (0.091, 0.166)
—+	graduation	0	303	251	146	151
	futility	0	0	0	0	0
	max_n	0	10	11	26	20
	n	21 (14, 27)	7 (2, 20)	8 (3, 20)	7 (2, 18)	7 (2, 18)
	n_unique	19 (12, 26)	6 (2, 18)	7 (3, 19)	6 (2, 17)	6 (2, 17)
	post_p	NA (NA, NA)	0.44 (0.18, 0.81)	0.46 (0.18, 0.83)	0.44 (0.16, 0.81)	0.47 (0.19, 0.82)
	rate	0.111 (0.078, 0.156)	0.122 (0.078, 0.282)	0.121 (0.076, 0.259)	0.125 (0.073, 0.268)	0.116 (0.071, 0.267)
–+-	graduation	0	99	71	40	34
	futility	0	0	0	0	0
	max_n	0	9	7	9	11
	n	62 (49, 76)	25 (9, 56)	26 (8, 53)	22 (7, 55)	24 (7, 53)
	n_unique	57 (44, 71)	23 (8, 53)	24 (7, 50)	20 (6, 52)	22 (7, 49)
	post_p	NA (NA, NA)	0.43 (0.1, 0.86)	0.48 (0.11, 0.88)	0.47 (0.11, 0.88)	0.49 (0.12, 0.86)
	rate	0.113 (0.095, 0.138)	0.119 (0.091, 0.197)	0.115 (0.09, 0.201)	0.119 (0.09, 0.202)	0.117 (0.09, 0.197)
–++	graduation	0	132	122	52	54
	futility	0	0	0	0	0
	max_n	0	10	7	9	11
	n	43 (33, 53)	15 (5, 37)	20 (8, 41)	14 (4, 34)	15 (4, 37)
	n_unique	39 (30, 49)	14 (4, 34)	18 (8, 39)	13 (4, 32)	14 (4, 35)
	post_p	NA (NA, NA)	0.44 (0.14, 0.84)	0.49 (0.14, 0.86)	0.47 (0.12, 0.84)	0.46 (0.13, 0.85)
	rate	0.113 (0.091, 0.141)	0.122 (0.09, 0.212)	0.116 (0.089, 0.183)	0.121 (0.083, 0.262)	0.119 (0.082, 0.224)
-+–	graduation	0	332	284	303	309
	futility	0	0	0	0	0
	max_n	0	8	10	23	19
	n	20 (14, 27)	4 (1, 12)	5 (2, 12)	12 (4, 23)	11 (4, 22)
	n_unique	18 (12, 25)	4 (1, 11)	5 (2, 11)	11 (3, 21)	10 (3, 21)
	post_p	NA (NA, NA)	0.36 (0.16, 0.68)	0.33 (0.14, 0.62)	0.95 (0.71, 1)	0.94 (0.68, 1)
	rate	0.115 (0.086, 0.162)	0.127 (0.068, 0.403)	0.129 (0.069, 0.316)	0.036 (0.018, 0.062)	0.037 (0.02, 0.067)
-+-+	graduation	0	347	309	303	312
	futility	0	0	0	0	0
	max_n	0	9	10	23	19
	n	20 (14, 28)	4 (0, 11)	5 (2, 12)	12 (4, 22)	12 (3, 21)
	n_unique	19 (13, 26)	4 (0, 10)	4 (1, 11)	11 (3, 20)	11 (3, 20)
	post_p	NA (NA, NA)	0.35 (0.15, 0.67)	0.34 (0.14, 0.63)	0.95 (0.66, 1)	0.95 (0.68, 1)
	rate	0.112 (0.08, 0.155)	0.129 (0.065, 0.343)	0.128 (0.071, 0.344)	0.037 (0.019, 0.068)	0.037 (0.019, 0.065)
-++-	graduation	0	178	170	264	255
	futility	0	0	0	0	0
	max_n	0	9	7	8	8
	n	11 (6, 17)	4 (1, 8)	4 (1, 9)	7 (2, 13)	8 (2, 14)
	n_unique	10 (6, 16)	3 (1, 7)	3 (1, 8)	6 (2, 12)	7 (2, 13)
	post_p	NA (NA, NA)	0.35 (0.19, 0.63)	0.36 (0.18, 0.66)	0.83 (0.54, 0.97)	0.84 (0.52, 0.98)
	rate	0.112 (0.072, 0.176)	0.132 (0.063, 0.364)	0.132 (0.062, 0.395)	0.036 (0.013, 0.079)	0.035 (0.016, 0.08)
-+++	graduation	0	206	206	265	260
	futility	0	0	0	0	0
	max_n	0	10	7	8	8
	n	12 (7, 17)	4 (1, 8)	4 (1, 8)	6 (2, 14)	7 (3, 13)
	n_unique	10 (6, 16)	3 (1, 8)	3 (1, 7)	6 (2, 13)	7 (2, 13)
	post_p	NA (NA, NA)	0.38 (0.19, 0.65)	0.35 (0.18, 0.63)	0.82 (0.54, 0.97)	0.85 (0.53, 0.98)
	rate	0.113 (0.074, 0.183)	0.127 (0.063, 0.353)	0.139 (0.063, 0.4)	0.037 (0.013, 0.085)	0.037 (0.015, 0.077)
+—	graduation	0	20	9	19	15
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	20 (13, 26)	8 (3, 17)	11 (4, 19)	8 (3, 17)	9 (3, 17)
	n_unique	18 (12, 25)	7 (3, 16)	10 (4, 18)	8 (2, 16)	8 (2, 16)
	post_p	NA (NA, NA)	0.46 (0.2, 0.83)	0.49 (0.17, 0.83)	0.47 (0.18, 0.85)	0.5 (0.21, 0.85)
	rate	0.115 (0.082, 0.161)	0.123 (0.079, 0.264)	0.118 (0.082, 0.228)	0.125 (0.071, 0.268)	0.115 (0.075, 0.267)
+–+	graduation	0	76	85	35	40
	futility	0	0	0	0	0
	max_n	0	1	0	0	1
	n	16 (10, 22)	7 (2, 15)	8 (3, 16)	6 (2, 14)	6 (2, 15)
	n_unique	14 (9, 20)	6 (2, 13)	8 (3, 15)	5 (2, 12)	6 (2, 14)
	post_p	NA (NA, NA)	0.46 (0.21, 0.8)	0.45 (0.2, 0.83)	0.47 (0.21, 0.79)	0.46 (0.2, 0.83)
	rate	0.115 (0.08, 0.162)	0.128 (0.077, 0.273)	0.124 (0.077, 0.248)	0.128 (0.072, 0.284)	0.127 (0.069, 0.324)
+-+-	graduation	0	99	71	40	34
	futility	0	0	0	0	0
	max_n	0	9	7	9	11
	n	16 (11, 22)	6 (2, 15)	8 (3, 16)	7 (2, 14)	6 (2, 13)
	n_unique	15 (9, 21)	6 (2, 14)	7 (3, 15)	6 (2, 13)	6 (2, 12)
	post_p	NA (NA, NA)	0.45 (0.21, 0.84)	0.46 (0.2, 0.8)	0.47 (0.2, 0.83)	0.47 (0.19, 0.78)
	rate	0.116 (0.08, 0.167)	0.13 (0.076, 0.299)	0.125 (0.081, 0.263)	0.122 (0.069, 0.284)	0.126 (0.073, 0.311)
+-++	graduation	0	132	122	52	54
	futility	0	0	0	0	0
	max_n	0	10	7	9	11
	n	16 (10, 21)	6 (2, 14)	8 (2, 16)	6 (2, 14)	6 (2, 15)
	n_unique	14 (9, 19)	6 (2, 13)	7 (2, 15)	6 (2, 13)	6 (2, 13)
	post_p	NA (NA, NA)	0.45 (0.22, 0.81)	0.45 (0.21, 0.82)	0.46 (0.21, 0.82)	0.48 (0.2, 0.79)
	rate	0.112 (0.078, 0.165)	0.127 (0.075, 0.28)	0.125 (0.077, 0.271)	0.122 (0.066, 0.287)	0.122 (0.073, 0.297)
++–	graduation	0	124	132	260	254
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	11 (7, 16)	4 (2, 9)	4 (2, 8)	7 (2, 13)	7 (2, 14)
	n_unique	10 (6, 15)	4 (1, 8)	4 (1, 7)	6 (2, 12)	6 (2, 12)
	post_p	NA (NA, NA)	0.37 (0.18, 0.59)	0.37 (0.19, 0.64)	0.83 (0.51, 0.98)	0.85 (0.55, 0.97)
	rate	0.113 (0.075, 0.179)	0.129 (0.067, 0.299)	0.125 (0.063, 0.331)	0.037 (0.015, 0.088)	0.036 (0.016, 0.086)
++-+	graduation	0	167	184	261	259
	futility	0	0	0	0	0
	max_n	0	1	0	0	1
	n	12 (7, 17)	4 (1, 8)	4 (1, 8)	6 (2, 14)	7 (2, 13)
	n_unique	10 (6, 15)	3 (1, 8)	3 (1, 7)	6 (2, 13)	6 (2, 12)
	post_p	NA (NA, NA)	0.36 (0.19, 0.62)	0.37 (0.2, 0.63)	0.83 (0.5, 0.98)	0.85 (0.5, 0.98)
	rate	0.116 (0.074, 0.182)	0.124 (0.063, 0.384)	0.123 (0.063, 0.286)	0.037 (0.015, 0.091)	0.037 (0.016, 0.079)
+++-	graduation	0	178	170	264	255
	futility	0	0	0	0	0
	max_n	0	9	7	8	8
	n	12 (7, 17)	4 (1, 8)	4 (1, 8)	6 (2, 13)	7 (2, 14)
	n_unique	10 (6, 16)	4 (1, 7)	3 (1, 7)	6 (2, 12)	6 (2, 13)
	post_p	NA (NA, NA)	0.36 (0.19, 0.65)	0.34 (0.19, 0.59)	0.82 (0.53, 0.97)	0.84 (0.52, 0.98)
	rate	0.113 (0.072, 0.182)	0.127 (0.062, 0.353)	0.137 (0.067, 0.394)	0.038 (0.015, 0.082)	0.037 (0.015, 0.082)
++++	graduation	0	206	206	265	260
	futility	0	0	0	0	0
	max_n	0	10	7	8	8
	n	12 (7, 17)	4 (1, 8)	4 (1, 8)	6 (2, 14)	7 (2, 14)
	n_unique	11 (6, 16)	3 (1, 7)	3 (1, 8)	6 (2, 13)	6 (2, 13)
	post_p	NA (NA, NA)	0.35 (0.17, 0.6)	0.37 (0.2, 0.64)	0.83 (0.49, 0.97)	0.84 (0.53, 0.98)
	rate	0.111 (0.071, 0.182)	0.127 (0.063, 0.402)	0.129 (0.059, 0.356)	0.038 (0.015, 0.093)	0.037 (0.015, 0.084)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	ARSi	Taxane_CT	Platinum_CT	PARPi
all	count	6	3	19	15
	time_stop	5 (4, 8)	5 (5, 6)	7 (6, 27)	8 (5, 33)
	n_trt	34 (28, 56)	34 (29, 34)	33 (28, 113)	34 (26, 213)
	n_control	61 (50, 83)	65 (55, 66)	77 (57, 302)	79 (60, 349)
	post_p	0.9 (0.89, 0.92)	0.86 (0.86, 0.94)	1 (0.95, 1)	0.99 (0.96, 1)
	order	1 (1, 1)	1 (1, 1)	1 (1, 2.2)	1 (1, 2)
TP53- & AR-	count	30	13	116	121
	time_stop	10 (7, 15)	12 (9, 16)	18 (12, 32)	21 (12, 33)
	n_trt	30 (26, 43)	31 (25, 43)	45 (27, 88)	49 (27, 99)
	n_control	42 (28, 63)	48 (38, 73)	78 (47, 148)	95 (50, 157)
	post_p	0.9 (0.86, 0.96)	0.9 (0.87, 0.98)	0.99 (0.92, 1)	0.99 (0.92, 1)
	order	1 (1, 2)	2 (1, 2.8)	2 (1, 3)	1 (1, 4)
TP53+	count	8	3	21	20
	time_stop	10 (9, 10)	8 (7, 13)	14 (10, 23)	13 (10, 25)
	n_trt	28 (25, 34)	26 (25, 32)	35 (26, 66)	35 (27, 66)
	n_control	38 (31, 42)	38 (34, 45)	65 (38, 110)	56 (39, 114)
	post_p	0.91 (0.87, 0.97)	0.88 (0.86, 0.89)	1 (0.95, 1)	0.99 (0.98, 1)
	order	1 (1, 1)	1 (1, 1)	2 (1, 4)	1 (1, 2.1)
HRD+	count			247	241
	time_stop			23 (13, 34)	26 (13, 35)
	n_trt			51 (26, 87)	58 (28, 89)
	n_control			64 (32, 109)	74 (35, 110)
	post_p			1 (0.99, 1)	1 (1, 1)
	order			2 (1, 3)	2 (1, 3)
TEfus+	count		2	18	27
	time_stop		12 (11, 13)	17 (12, 28)	16 (11, 30)
	n_trt		30 (29, 30)	32 (26, 52)	31 (26, 78)
	n_control		42 (36, 48)	58 (43, 119)	63 (35, 122)
	post_p		0.94 (0.92, 0.96)	1 (0.98, 1)	0.99 (0.97, 1)
	order		1 (1, 1)	2.5 (1, 4)	2 (1, 3)

Futility:

signature	var	ARSi	Taxane_CT	Platinum_CT	PARPi
all	count	14	6
	time_stop	14 (3, 30)	9 (4, 30)
	n_trt	68 (27, 97)	46 (30, 104)
	n_control	125 (34, 368)	88 (40, 352)
	post_p	0.06 (0.01, 0.2)	0.06 (0.01, 0.16)
	order	2 (1, 4.4)	1.5 (1, 3.5)
TP53- & AR-	count	243	196	5	5
	time_stop	15 (7, 29)	20 (12, 32)	17 (13, 23)	14 (12, 15)
	n_trt	34 (25, 74)	37 (25, 69)	37 (30, 46)	34 (26, 35)
	n_control	60 (30, 135)	88 (50, 156)	60 (51, 97)	58 (48, 64)
	post_p	0.16 (0.05, 0.28)	0.17 (0.07, 0.27)	0.18 (0.12, 0.24)	0.18 (0.04, 0.27)
	order	1 (1, 2)	2 (1, 3)	1 (1, 1.6)	1 (1, 3)
TP53+	count	79	63
	time_stop	20 (12, 33)	18 (10, 32)
	n_trt	42 (27, 68)	42 (28, 76)
	n_control	89 (47, 160)	89 (39, 170)
	post_p	0.08 (0.03, 0.21)	0.1 (0.02, 0.23)
	order	2 (1, 4)	2 (1, 3)
HRD+	count	107	123
	time_stop	29 (23, 34)	28 (20, 34)
	n_trt	29 (25, 43)	31 (25, 46)
	n_control	83 (54, 109)	81 (52, 108)
	post_p	0.1 (0.03, 0.25)	0.1 (0.01, 0.25)
	order	2 (1, 4)	2 (1, 4)
TEfus+	count	62	76
	time_stop	22 (16, 34)	22 (12, 32)
	n_trt	39 (26, 65)	39 (28, 67)
	n_control	86 (54, 139)	88 (46, 132)
	post_p	0.07 (0.02, 0.18)	0.06 (0.02, 0.18)
	order	2 (1, 4)	2 (1, 4)

By subgroup combinations

Graduation:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	ARSi	count	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6
		time	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)
		n	16 (12, 22)	2 (1, 3)	8 (6, 14)	2 (2, 4)	0 (0, 4)	0 (0, 2)	0 (0, 1)	0 (0, 0)	2 (0, 3)	2 (0, 2)	0 (0, 2)	1 (0, 1)	0 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)
		post_p	0.62 (0.58, 0.75)	0.53 (0.51, 0.56)	0.61 (0.51, 0.8)	0.53 (0.52, 0.63)	0.55 (0.51, 0.57)	0.52 (0.52, 0.52)	0.55 (0.55, 0.55)	NA (NA, NA)	0.57 (0.53, 0.65)	0.53 (0.52, 0.54)	0.52 (0.52, 0.53)	0.55 (0.54, 0.56)	0.55 (0.52, 0.57)	NA (NA, NA)	0.54 (0.54, 0.54)	NA (NA, NA)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.057 (0.035, 0.109)	0 (0, 0.043)	0.06 (0.026, 0.111)	0 (0, 0.056)	0 (0, 0)	0 (0, 0)	0.214 (0.043, 0.386)	NA (NA, NA)	0 (0, 0)	0 (0, 0.06)	0.124 (0.025, 0.153)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
	Taxane_CT	count	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3
		time	5 (5, 6)	5 (5, 6)	5 (5, 6)	5 (5, 6)	5 (5, 6)	5 (5, 6)	5 (5, 6)	5 (5, 6)	5 (5, 6)	5 (5, 6)	5 (5, 6)	5 (5, 6)	5 (5, 6)	5 (5, 6)	5 (5, 6)	5 (5, 6)
		n	5 (3, 6)	1 (0, 3)	6 (3, 6)	7 (7, 9)	0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 0)	4 (2, 6)	3 (1, 3)	4 (2, 5)	1 (0, 3)	0 (0, 2)	0 (0, 1)	0 (0, 2)	0 (0, 0)
		post_p	0.56 (0.51, 0.68)	0.54 (0.53, 0.55)	0.58 (0.56, 0.67)	0.58 (0.57, 0.88)	NA (NA, NA)	0.54 (0.54, 0.54)	NA (NA, NA)	NA (NA, NA)	0.56 (0.52, 0.58)	0.54 (0.52, 0.57)	0.53 (0.52, 0.58)	0.56 (0.54, 0.58)	0.55 (0.55, 0.55)	0.54 (0.54, 0.54)	0.5 (0.5, 0.5)	NA (NA, NA)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.085 (0.057, 0.136)	0.064 (0.013, 0.116)	0 (0, 0)	0.071 (0.061, 0.094)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0 (0, 0.081)	0.131 (0.096, 0.166)	0.144 (0.029, 0.164)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)
	Platinum_CT	count	19	19	19	19	19	19	19	19	19	19	19	19	19	19	19	19
		time	7 (6, 27)	7 (6, 27)	7 (6, 27)	7 (6, 27)	7 (6, 27)	7 (6, 27)	7 (6, 27)	7 (6, 27)	7 (6, 27)	7 (6, 27)	7 (6, 27)	7 (6, 27)	7 (6, 27)	7 (6, 27)	7 (6, 27)	7 (6, 27)
		n	5 (2, 24)	1 (0, 4)	7 (3, 15)	2 (1, 14)	3 (2, 6)	3 (1, 10)	2 (0, 5)	1 (0, 5)	1 (0, 9)	2 (0, 5)	1 (0, 4)	1 (0, 5)	2 (1, 5)	1 (0, 5)	2 (0, 6)	2 (1, 5)
		post_p	0.61 (0.54, 0.87)	0.61 (0.52, 0.79)	0.59 (0.52, 0.69)	0.58 (0.52, 0.77)	0.55 (0.52, 0.85)	0.58 (0.52, 0.81)	0.54 (0.52, 0.62)	0.54 (0.51, 0.64)	0.55 (0.5, 0.76)	0.6 (0.53, 0.86)	0.59 (0.52, 0.72)	0.53 (0.51, 0.6)	0.55 (0.52, 0.7)	0.56 (0.51, 0.72)	0.58 (0.51, 0.81)	0.56 (0.51, 0.78)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0 (0, 0.103)	0 (0, 0.064)	0.074 (0, 0.113)	0 (0, 0.093)	0 (0, 0.029)	0 (0, 0.052)	0 (0, 0.059)	0 (0, 0.053)	0.058 (0, 0.215)	0 (0, 0.089)	0 (0, 0.047)	0 (0, 0.134)	0 (0, 0.037)	0 (0, 0.047)	0 (0, 0.076)	0 (0, 0.043)
	PARPi	count	15	15	15	15	15	15	15	15	15	15	15	15	15	15	15	15
		time	8 (5, 33)	8 (5, 33)	8 (5, 33)	8 (5, 33)	8 (5, 33)	8 (5, 33)	8 (5, 33)	8 (5, 33)	8 (5, 33)	8 (5, 33)	8 (5, 33)	8 (5, 33)	8 (5, 33)	8 (5, 33)	8 (5, 33)	8 (5, 33)
		n	6 (2, 23)	1 (0, 4)	7 (3, 29)	2 (0, 19)	4 (2, 6)	5 (1, 7)	1 (0, 10)	2 (1, 12)	1 (0, 12)	1 (0, 5)	1 (0, 12)	2 (0, 11)	2 (0, 10)	3 (1, 8)	2 (0, 8)	3 (0, 9)
		post_p	0.56 (0.52, 0.87)	0.55 (0.52, 0.66)	0.66 (0.55, 0.78)	0.56 (0.52, 0.74)	0.55 (0.51, 0.75)	0.57 (0.51, 0.92)	0.54 (0.51, 0.82)	0.54 (0.52, 0.8)	0.61 (0.53, 0.79)	0.54 (0.52, 0.7)	0.61 (0.52, 0.72)	0.55 (0.51, 0.62)	0.6 (0.53, 0.91)	0.53 (0.51, 0.86)	0.56 (0.51, 0.86)	0.55 (0.51, 0.64)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0 (0, 0.158)	0 (0, 0.099)	0 (0, 0.112)	0 (0, 0.11)	0 (0, 0.064)	0 (0, 0.077)	0 (0, 0.041)	0 (0, 0.049)	0 (0, 0.077)	0.025 (0, 0.128)	0 (0, 0.081)	0.084 (0, 0.111)	0 (0, 0.075)	0 (0, 0.079)	0 (0, 0.048)	0.02 (0, 0.082)
TP53- & AR-	ARSi	count	30	30			30	30
		time	10 (7, 15)	10 (7, 15)			10 (7, 15)	10 (7, 15)
		n	26 (19, 34)	3 (2, 5)			1 (0, 3)	2 (0, 4)
		post_p	0.85 (0.74, 0.93)	0.63 (0.52, 0.72)			0.57 (0.52, 0.62)	0.55 (0.51, 0.62)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.074 (0.054, 0.093)	0.044 (0, 0.104)			0 (0, 0.042)	0 (0, 0.06)
	Taxane_CT	count	13	13			13	13
		time	12 (9, 16)	12 (9, 16)			12 (9, 16)	12 (9, 16)
		n	24 (17, 31)	4 (1, 5)			3 (0, 6)	2 (0, 5)
		post_p	0.84 (0.75, 0.92)	0.59 (0.51, 0.75)			0.56 (0.52, 0.73)	0.56 (0.54, 0.7)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.064 (0.036, 0.088)	0.039 (0, 0.081)			0 (0, 0.059)	0 (0, 0.087)
	Platinum_CT	count	116	116			116	116
		time	18 (12, 32)	18 (12, 32)			18 (12, 32)	18 (12, 32)
		n	22 (14, 54)	5 (1, 12)			6 (3, 14)	6 (3, 14)
		post_p	0.78 (0.71, 0.9)	0.64 (0.51, 0.88)			0.74 (0.54, 0.98)	0.74 (0.54, 0.95)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.086 (0.051, 0.106)	0.076 (0, 0.116)			0.024 (0, 0.072)	0.031 (0, 0.062)
	PARPi	count	121	121			121	121
		time	21 (12, 33)	21 (12, 33)			21 (12, 33)	21 (12, 33)
		n	27 (14, 64)	5 (2, 13)			8 (3, 16)	8 (3, 17)
		post_p	0.79 (0.71, 0.91)	0.64 (0.52, 0.85)			0.78 (0.54, 0.97)	0.78 (0.55, 0.97)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.089 (0.059, 0.108)	0.076 (0, 0.115)			0.03 (0, 0.061)	0.028 (0, 0.057)
TP53+	ARSi	count			8	8			8	8			8	8			8	8
		time			10 (9, 10)	10 (9, 10)			10 (9, 10)	10 (9, 10)			10 (9, 10)	10 (9, 10)			10 (9, 10)	10 (9, 10)
		n			14 (11, 21)	4 (3, 7)			2 (1, 2)	1 (0, 2)			2 (2, 4)	2 (0, 3)			1 (0, 2)	2 (0, 2)
		post_p			0.78 (0.73, 0.9)	0.63 (0.53, 0.77)			0.54 (0.51, 0.62)	0.53 (0.51, 0.58)			0.54 (0.51, 0.63)	0.56 (0.52, 0.62)			0.52 (0.51, 0.56)	0.56 (0.54, 0.6)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.058 (0.049, 0.094)	0.072 (0.028, 0.122)			0 (0, 0.118)	0 (0, 0)			0.086 (0, 0.176)	0 (0, 0.129)			0 (0, 0.165)	0 (0, 0)
	Taxane_CT	count			3	3			3	3			3	3			3	3
		time			8 (7, 13)	8 (7, 13)			8 (7, 13)	8 (7, 13)			8 (7, 13)	8 (7, 13)			8 (7, 13)	8 (7, 13)
		n			12 (6, 12)	11 (7, 12)			0 (0, 2)	1 (0, 3)			3 (1, 5)	3 (1, 5)			1 (0, 2)	0 (0, 0)
		post_p			0.71 (0.66, 0.74)	0.75 (0.71, 0.81)			0.5 (0.5, 0.5)	0.54 (0.52, 0.56)			0.55 (0.52, 0.58)	0.58 (0.53, 0.77)			0.51 (0.5, 0.52)	NA (NA, NA)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.051 (0.047, 0.082)	0.058 (0.012, 0.098)			0 (0, 0)	0.034 (0.007, 0.061)			0.017 (0.003, 0.03)	0 (0, 0.037)			0.054 (0.011, 0.097)	NA (NA, NA)
	Platinum_CT	count			21	21			21	21			21	21			21	21
		time			14 (10, 23)	14 (10, 23)			14 (10, 23)	14 (10, 23)			14 (10, 23)	14 (10, 23)			14 (10, 23)	14 (10, 23)
		n			12 (6, 21)	6 (3, 13)			3 (1, 5)	4 (2, 8)			3 (0, 5)	2 (1, 5)			4 (2, 6)	3 (1, 5)
		post_p			0.8 (0.71, 0.97)	0.72 (0.64, 0.81)			0.58 (0.52, 0.8)	0.66 (0.54, 0.75)			0.58 (0.51, 0.75)	0.59 (0.51, 0.78)			0.64 (0.56, 0.8)	0.56 (0.52, 0.71)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.071 (0.028, 0.101)	0.05 (0, 0.105)			0 (0, 0.061)	0.009 (0, 0.056)			0.076 (0, 0.125)	0.059 (0, 0.119)			0.029 (0, 0.059)	0.026 (0, 0.063)
	PARPi	count			20	20			20	20			20	20			20	20
		time			13 (10, 25)	13 (10, 25)			13 (10, 25)	13 (10, 25)			13 (10, 25)	13 (10, 25)			13 (10, 25)	13 (10, 25)
		n			12 (7, 23)	5 (2, 12)			3 (1, 5)	3 (2, 6)			2 (1, 5)	2 (0, 4)			4 (1, 5)	4 (1, 5)
		post_p			0.8 (0.7, 0.9)	0.73 (0.52, 0.83)			0.59 (0.51, 0.73)	0.61 (0.51, 0.84)			0.61 (0.54, 0.74)	0.57 (0.51, 0.84)			0.6 (0.52, 0.81)	0.58 (0.52, 0.69)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.067 (0.037, 0.097)	0.061 (0, 0.101)			0.023 (0, 0.09)	0 (0, 0.046)			0.019 (0, 0.119)	0.069 (0, 0.138)			0.018 (0, 0.052)	0 (0, 0.051)
HRD+	Platinum_CT	count					247	247	247	247					247	247	247	247
		time					23 (13, 34)	23 (13, 34)	23 (13, 34)	23 (13, 34)					23 (13, 34)	23 (13, 34)	23 (13, 34)	23 (13, 34)
		n					9 (4, 17)	9 (4, 17)	5 (2, 11)	5 (2, 11)					5 (2, 11)	5 (2, 12)	5 (2, 11)	5 (2, 11)
		post_p					0.81 (0.61, 0.98)	0.78 (0.58, 0.98)	0.73 (0.54, 0.92)	0.71 (0.54, 0.93)					0.72 (0.53, 0.92)	0.72 (0.54, 0.94)	0.72 (0.52, 0.92)	0.71 (0.54, 0.93)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.031 (0, 0.056)	0.035 (0, 0.064)	0.032 (0, 0.062)	0.028 (0, 0.073)					0.03 (0, 0.07)	0.03 (0, 0.062)	0.03 (0, 0.075)	0.027 (0, 0.07)
	PARPi	count					241	241	241	241					241	241	241	241
		time					26 (13, 35)	26 (13, 35)	26 (13, 35)	26 (13, 35)					26 (13, 35)	26 (13, 35)	26 (13, 35)	26 (13, 35)
		n					9 (3, 19)	10 (3, 19)	6 (2, 11)	5 (2, 11)					5 (2, 11)	5 (2, 11)	5 (2, 12)	5 (2, 12)
		post_p					0.8 (0.6, 0.98)	0.84 (0.6, 0.99)	0.73 (0.54, 0.92)	0.75 (0.54, 0.95)					0.74 (0.53, 0.94)	0.73 (0.54, 0.94)	0.74 (0.54, 0.95)	0.76 (0.54, 0.95)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.033 (0, 0.064)	0.034 (0, 0.063)	0.028 (0, 0.062)	0.031 (0, 0.07)					0.029 (0, 0.075)	0.029 (0, 0.063)	0.03 (0, 0.066)	0.028 (0, 0.064)
TEfus+	Taxane_CT	count		2		2		2		2		2		2		2		2
		time		12 (11, 13)		12 (11, 13)		12 (11, 13)		12 (11, 13)		12 (11, 13)		12 (11, 13)		12 (11, 13)		12 (11, 13)
		n		4 (3, 5)		14 (12, 16)		3 (2, 4)		2 (1, 3)		2 (1, 3)		2 (1, 2)		2 (2, 3)		0 (0, 0)
		post_p		0.57 (0.55, 0.59)		0.84 (0.8, 0.87)		0.53 (0.51, 0.55)		0.6 (0.55, 0.65)		0.59 (0.58, 0.59)		0.52 (0.5, 0.53)		0.55 (0.55, 0.55)		NA (NA, NA)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0.073 (0.064, 0.081)		0.065 (0.051, 0.079)		0.059 (0.012, 0.105)		0 (0, 0)		0 (0, 0)		0.039 (0.008, 0.07)		0.032 (0.006, 0.058)		NA (NA, NA)
	Platinum_CT	count		18		18		18		18		18		18		18		18
		time		17 (12, 28)		17 (12, 28)		17 (12, 28)		17 (12, 28)		17 (12, 28)		17 (12, 28)		17 (12, 28)		17 (12, 28)
		n		3 (1, 5)		8 (4, 15)		5 (4, 9)		3 (2, 7)		3 (1, 5)		4 (1, 7)		3 (1, 5)		4 (3, 9)
		post_p		0.61 (0.54, 0.76)		0.78 (0.62, 0.87)		0.77 (0.53, 0.93)		0.6 (0.54, 0.81)		0.66 (0.51, 0.76)		0.63 (0.52, 0.9)		0.58 (0.52, 0.78)		0.63 (0.53, 0.9)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.057 (0, 0.11)		0.072 (0.027, 0.101)		0.034 (0.012, 0.068)		0.013 (0, 0.07)		0.047 (0, 0.112)		0.071 (0.016, 0.109)		0 (0, 0.052)		0.016 (0, 0.07)
	PARPi	count		27		27		27		27		27		27		27		27
		time		16 (11, 30)		16 (11, 30)		16 (11, 30)		16 (11, 30)		16 (11, 30)		16 (11, 30)		16 (11, 30)		16 (11, 30)
		n		4 (2, 7)		9 (4, 25)		5 (2, 12)		3 (3, 8)		3 (2, 7)		3 (0, 8)		3 (1, 6)		3 (1, 5)
		post_p		0.62 (0.52, 0.78)		0.75 (0.55, 0.91)		0.73 (0.56, 0.93)		0.66 (0.54, 0.84)		0.56 (0.53, 0.76)		0.58 (0.51, 0.79)		0.57 (0.54, 0.79)		0.58 (0.52, 0.84)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.073 (0, 0.096)		0.071 (0, 0.1)		0.024 (0, 0.044)		0 (0, 0.047)		0.081 (0, 0.132)		0.056 (0, 0.123)		0.022 (0, 0.073)		0.023 (0, 0.074)

Futility:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	ARSi	count	14	14	14	14	14	14	14	14	14	14	14	14	14	14	14	14
		time	14 (3, 30)	14 (3, 30)	14 (3, 30)	14 (3, 30)	14 (3, 30)	14 (3, 30)	14 (3, 30)	14 (3, 30)	14 (3, 30)	14 (3, 30)	14 (3, 30)	14 (3, 30)	14 (3, 30)	14 (3, 30)	14 (3, 30)	14 (3, 30)
		n	20 (9, 41)	2 (1, 5)	10 (6, 16)	4 (1, 10)	2 (0, 4)	2 (0, 5)	1 (0, 3)	2 (0, 3)	3 (0, 7)	2 (0, 5)	2 (0, 4)	2 (0, 6)	0 (0, 3)	2 (0, 4)	0 (0, 3)	1 (0, 4)
		post_p	0.36 (0.08, 0.48)	0.42 (0.26, 0.48)	0.42 (0.09, 0.48)	0.35 (0.21, 0.48)	0.39 (0.32, 0.46)	0.38 (0.28, 0.46)	0.41 (0.3, 0.44)	0.39 (0.27, 0.46)	0.4 (0.23, 0.49)	0.42 (0.34, 0.47)	0.47 (0.35, 0.5)	0.43 (0.25, 0.48)	0.35 (0.23, 0.43)	0.42 (0.27, 0.48)	0.41 (0.35, 0.45)	0.42 (0.24, 0.5)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.137 (0.103, 0.244)	0.152 (0.097, 0.397)	0.128 (0.072, 0.249)	0.153 (0.119, 0.336)	0.182 (0.086, 0.424)	0.141 (0.099, 0.358)	0.176 (0, 0.437)	0.134 (0.086, 0.275)	0.163 (0.093, 0.512)	0.176 (0.114, 0.378)	0.104 (0, 0.267)	0.169 (0.127, 0.385)	0.286 (0.1, 1.281)	0.133 (0, 0.308)	0.714 (0.113, 4.647)	0.188 (0.098, 0.801)
	Taxane_CT	count	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6
		time	9 (4, 30)	9 (4, 30)	9 (4, 30)	9 (4, 30)	9 (4, 30)	9 (4, 30)	9 (4, 30)	9 (4, 30)	9 (4, 30)	9 (4, 30)	9 (4, 30)	9 (4, 30)	9 (4, 30)	9 (4, 30)	9 (4, 30)	9 (4, 30)
		n	8 (4, 26)	4 (0, 12)	6 (2, 12)	10 (8, 14)	2 (0, 4)	2 (0, 5)	1 (0, 1)	0 (0, 1)	4 (2, 10)	4 (1, 7)	4 (2, 4)	2 (2, 4)	0 (0, 2)	0 (0, 4)	0 (0, 3)	0 (0, 2)
		post_p	0.36 (0.26, 0.47)	0.44 (0.27, 0.47)	0.43 (0.25, 0.47)	0.41 (0.17, 0.49)	0.3 (0.13, 0.41)	0.37 (0.37, 0.38)	0.35 (0.35, 0.47)	0.4 (0.34, 0.45)	0.42 (0.26, 0.48)	0.46 (0.28, 0.47)	0.4 (0.3, 0.46)	0.46 (0.38, 0.48)	0.39 (0.39, 0.43)	0.35 (0.23, 0.46)	0.37 (0.12, 0.46)	0.39 (0.31, 0.48)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.12 (0.106, 0.305)	0.122 (0.088, 0.275)	0.14 (0.103, 0.251)	0.138 (0.088, 0.219)	0.243 (0.183, 1.153)	0.22 (0.129, 0.274)	0.517 (0.105, 1.094)	1.009 (0.522, 1.496)	0.149 (0.064, 0.211)	0.165 (0.093, 0.213)	0.209 (0.156, 0.294)	0.136 (0.026, 1.099)	0.184 (0.147, 1.928)	0.094 (0.066, 0.122)	0.257 (0.158, 0.361)	0.286 (0.057, 0.516)
TP53- & AR-	ARSi	count	243	243			243	243
		time	15 (7, 29)	15 (7, 29)			15 (7, 29)	15 (7, 29)
		n	22 (16, 54)	5 (2, 10)			3 (1, 7)	3 (0, 6)
		post_p	0.32 (0.09, 0.47)	0.4 (0.21, 0.48)			0.4 (0.2, 0.48)	0.41 (0.27, 0.48)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.13 (0.103, 0.178)	0.156 (0.09, 0.369)			0.145 (0.074, 0.489)	0.144 (0.07, 0.427)
	Taxane_CT	count	196	196			196	196
		time	20 (12, 32)	20 (12, 32)			20 (12, 32)	20 (12, 32)
		n	22 (10, 50)	5 (3, 12)			4 (2, 8)	4 (1, 8)
		post_p	0.34 (0.1, 0.48)	0.38 (0.2, 0.48)			0.37 (0.19, 0.48)	0.38 (0.19, 0.47)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.129 (0.106, 0.194)	0.149 (0.094, 0.266)			0.143 (0.087, 0.321)	0.143 (0.082, 0.451)
	Platinum_CT	count	5	5			5	5
		time	17 (13, 23)	17 (13, 23)			17 (13, 23)	17 (13, 23)
		n	27 (14, 35)	3 (2, 5)			5 (3, 6)	3 (2, 6)
		post_p	0.26 (0.16, 0.44)	0.43 (0.28, 0.48)			0.4 (0.38, 0.46)	0.34 (0.23, 0.42)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.118 (0.113, 0.22)	0.152 (0.09, 0.401)			0.073 (0.052, 0.138)	0.165 (0.135, 0.281)
	PARPi	count	5	5			5	5
		time	14 (12, 15)	14 (12, 15)			14 (12, 15)	14 (12, 15)
		n	20 (16, 23)	3 (1, 3)			5 (3, 7)	5 (0, 7)
		post_p	0.22 (0.1, 0.35)	0.27 (0.22, 0.38)			0.48 (0.39, 0.49)	0.44 (0.42, 0.48)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.138 (0.117, 0.197)	0.722 (0.295, 28.445)			0.078 (0.055, 0.152)	0.096 (0.075, 0.113)
TP53+	ARSi	count			79	79			79	79			79	79			79	79
		time			20 (12, 33)	20 (12, 33)			20 (12, 33)	20 (12, 33)			20 (12, 33)	20 (12, 33)			20 (12, 33)	20 (12, 33)
		n			14 (7, 28)	8 (4, 20)			3 (1, 5)	2 (1, 5)			4 (2, 8)	3 (1, 7)			2 (0, 6)	3 (0, 6)
		post_p			0.34 (0.09, 0.46)	0.34 (0.14, 0.46)			0.37 (0.24, 0.46)	0.43 (0.29, 0.48)			0.4 (0.19, 0.49)	0.38 (0.26, 0.48)			0.4 (0.22, 0.48)	0.4 (0.23, 0.48)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.135 (0.106, 0.259)	0.142 (0.109, 0.235)			0.17 (0.077, 0.509)	0.179 (0.061, 0.414)			0.181 (0.104, 0.414)	0.167 (0.108, 0.427)			0.171 (0.094, 0.789)	0.157 (0.087, 0.588)
	Taxane_CT	count			63	63			63	63			63	63			63	63
		time			18 (10, 32)	18 (10, 32)			18 (10, 32)	18 (10, 32)			18 (10, 32)	18 (10, 32)			18 (10, 32)	18 (10, 32)
		n			12 (6, 29)	11 (5, 21)			2 (0, 6)	2 (0, 5)			4 (2, 9)	4 (2, 10)			2 (0, 6)	2 (0, 6)
		post_p			0.33 (0.13, 0.48)	0.38 (0.13, 0.48)			0.41 (0.26, 0.48)	0.38 (0.21, 0.48)			0.38 (0.22, 0.48)	0.42 (0.22, 0.48)			0.41 (0.24, 0.48)	0.41 (0.29, 0.48)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.139 (0.103, 0.235)	0.136 (0.101, 0.276)			0.133 (0.073, 0.644)	0.162 (0.069, 0.672)			0.159 (0.108, 0.399)	0.164 (0.097, 0.334)			0.174 (0.091, 0.454)	0.163 (0.066, 1.401)
HRD+	ARSi	count					107	107	107	107					107	107	107	107
		time					29 (23, 34)	29 (23, 34)	29 (23, 34)	29 (23, 34)					29 (23, 34)	29 (23, 34)	29 (23, 34)	29 (23, 34)
		n					4 (1, 9)	4 (1, 9)	4 (1, 6)	4 (1, 7)					4 (1, 7)	3 (2, 7)	3 (1, 6)	4 (1, 7)
		post_p					0.29 (0.16, 0.45)	0.32 (0.16, 0.45)	0.33 (0.17, 0.45)	0.38 (0.19, 0.48)					0.34 (0.17, 0.47)	0.34 (0.19, 0.47)	0.34 (0.2, 0.46)	0.37 (0.15, 0.47)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.151 (0.089, 0.48)	0.145 (0.09, 0.507)	0.164 (0.088, 0.356)	0.144 (0.076, 0.3)					0.157 (0.08, 0.374)	0.159 (0.092, 0.434)	0.163 (0.088, 0.719)	0.149 (0.086, 0.437)
	Taxane_CT	count					123	123	123	123					123	123	123	123
		time					28 (20, 34)	28 (20, 34)	28 (20, 34)	28 (20, 34)					28 (20, 34)	28 (20, 34)	28 (20, 34)	28 (20, 34)
		n					4 (2, 10)	5 (2, 11)	3 (1, 6)	3 (1, 7)					4 (1, 6)	3 (1, 6)	3 (1, 6)	3 (1, 7)
		post_p					0.3 (0.14, 0.45)	0.33 (0.14, 0.47)	0.36 (0.2, 0.46)	0.36 (0.21, 0.48)					0.36 (0.19, 0.48)	0.37 (0.19, 0.46)	0.34 (0.22, 0.48)	0.34 (0.22, 0.48)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.147 (0.09, 0.334)	0.127 (0.083, 0.338)	0.149 (0.084, 0.349)	0.153 (0.085, 0.45)					0.129 (0.074, 0.464)	0.16 (0.08, 0.509)	0.182 (0.079, 0.615)	0.142 (0.087, 0.403)
TEfus+	ARSi	count		62		62		62		62		62		62		62		62
		time		22 (16, 34)		22 (16, 34)		22 (16, 34)		22 (16, 34)		22 (16, 34)		22 (16, 34)		22 (16, 34)		22 (16, 34)
		n		6 (2, 12)		11 (4, 27)		3 (0, 7)		3 (1, 7)		4 (2, 8)		4 (2, 9)		2 (0, 6)		3 (1, 6)
		post_p		0.38 (0.19, 0.47)		0.3 (0.14, 0.46)		0.37 (0.17, 0.45)		0.37 (0.22, 0.48)		0.39 (0.22, 0.48)		0.39 (0.22, 0.48)		0.36 (0.18, 0.45)		0.4 (0.2, 0.48)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.15 (0.096, 0.383)		0.139 (0.109, 0.234)		0.141 (0.085, 0.264)		0.158 (0.073, 0.403)		0.151 (0.108, 0.446)		0.163 (0.09, 0.409)		0.163 (0.082, 0.472)		0.138 (0.083, 0.348)
	Taxane_CT	count		76		76		76		76		76		76		76		76
		time		22 (12, 32)		22 (12, 32)		22 (12, 32)		22 (12, 32)		22 (12, 32)		22 (12, 32)		22 (12, 32)		22 (12, 32)
		n		5 (2, 12)		11 (6, 21)		4 (1, 10)		3 (0, 5)		5 (2, 9)		5 (2, 11)		3 (0, 5)		2 (0, 6)
		post_p		0.36 (0.18, 0.47)		0.36 (0.13, 0.48)		0.37 (0.17, 0.46)		0.38 (0.22, 0.49)		0.36 (0.21, 0.47)		0.38 (0.21, 0.48)		0.38 (0.22, 0.48)		0.39 (0.26, 0.48)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0.161 (0.104, 0.336)		0.134 (0.104, 0.232)		0.146 (0.094, 0.446)		0.166 (0.065, 0.642)		0.175 (0.092, 0.463)		0.157 (0.097, 0.325)		0.172 (0.074, 0.471)		0.165 (0.091, 0.523)