Simulation scenario 4, CR phase

Setting description

ARSi more effective in the TP53- & AR- biomarker signature

Simulations setting

Survival curves (by signature)

PFS distributions (by signature)

Treatment effects (by signature)

signature	var	Other	ARSi	Taxane_CT	Platinum_CT	PARPi
all	param	scale = 0.112, shape = 1.05	scale = 0.084, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 11.7, median = 8.4	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1.33, hr = 0.74	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
TP53- & AR-	param	scale = 0.112, shape = 1.05	scale = 0.042, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 23.4, median = 16.9	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.67, hr = 0.36	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
TP53+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
HRD+	param	scale = 0.112, shape = 1.05	scale = 0.087, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 11.3, median = 8.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1.28, hr = 0.77	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
TEfus+	param	scale = 0.112, shape = 1.05	scale = 0.093, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 10.5, median = 7.6	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1.2, hr = 0.83	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1

Survival curves (by subgroup)

PFS distributions (by subgroup)

Treatment effects (by subgroup)

subtype	var	Other	ARSi	Taxane_CT	Platinum_CT	PARPi
—-	param	scale = 0.112, shape = 1.05	scale = 0.042, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 23.4, median = 16.9	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.67, hr = 0.36	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—+	param	scale = 0.112, shape = 1.05	scale = 0.042, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 23.4, median = 16.9	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.67, hr = 0.36	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+–	param	scale = 0.112, shape = 1.05	scale = 0.042, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 23.4, median = 16.9	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.67, hr = 0.36	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+-+	param	scale = 0.112, shape = 1.05	scale = 0.042, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 23.4, median = 16.9	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.67, hr = 0.36	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+—	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+–+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1

Errors and power

graduation (counts and proportions):

ARSi Taxane_CT Platinum_CT PARPi all 29 2 1 0 TP53- & AR- 414 6 3 2 TP53+ 6 0 3 2 HRD+ 5 0 1 1 TEfus+ 8 3 2 3

ARSi Taxane_CT Platinum_CT PARPi all 0.058 0.004 0.002 0.000 TP53- & AR- 0.828 0.012 0.006 0.004 TP53+ 0.012 0.000 0.006 0.004 HRD+ 0.010 0.000 0.002 0.002 TEfus+ 0.016 0.006 0.004 0.006

futility (counts and proportions):

ARSi Taxane_CT Platinum_CT PARPi all 4 4 2 1 TP53- & AR- 1 386 405 401 TP53+ 31 39 26 26 HRD+ 2 39 58 36 TEfus+ 6 61 43 40

ARSi Taxane_CT Platinum_CT PARPi all 0.008 0.008 0.004 0.002 TP53- & AR- 0.002 0.772 0.810 0.802 TP53+ 0.062 0.078 0.052 0.052 HRD+ 0.004 0.078 0.116 0.072 TEfus+ 0.012 0.122 0.086 0.080

max sample size (counts and proportions):

ARSi Taxane_CT Platinum_CT PARPi all 0 0 0 0 TP53- & AR- 50 18 19 25 TP53+ 4 11 10 7 HRD+ 0 0 0 0 TEfus+ 1 0 0 0

ARSi Taxane_CT Platinum_CT PARPi all 0.000 0.000 0.000 0.000 TP53- & AR- 0.100 0.036 0.038 0.050 TP53+ 0.008 0.022 0.020 0.014 HRD+ 0.000 0.000 0.000 0.000 TEfus+ 0.002 0.000 0.000 0.000

Errors & power

The overall error was 0.09.
The corresponding errors separate for the different treatments were:

       ARSi   Taxane_CT Platinum_CT       PARPi 
      0.044       0.022       0.020       0.016 

The overall power was 0.828.
The corresponding power separate for the different treatments were:

       ARSi   Taxane_CT Platinum_CT       PARPi 
      0.828       0.000       0.000       0.000 

Median results at the end of the trial

By signature:

signature	var	Control	ARSi	Taxane_CT	Platinum_CT	PARPi
all	graduation	0	29	2	1	0
	futility	0	4	4	2	1
	max_n	0	0	0	0	0
	n	411 (348, 451)	159 (104, 256)	174 (126, 248)	163 (118, 247)	173 (124, 251)
	n_unique	379 (321, 417)	146 (94, 242)	160 (115, 228)	150 (108, 230)	159 (113, 234)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	5 (4, 8)	11 (6, 24)	19 (9, 27)	22 (22, 22)
	post_p	NA (NA, NA)	0.97 (0.67, 1)	0.04 (0, 0.28)	0.04 (0, 0.3)	0.05 (0, 0.32)
	rate	0.094 (0.087, 0.101)	0.077 (0.061, 0.09)	0.114 (0.102, 0.126)	0.114 (0.102, 0.126)	0.112 (0.101, 0.126)
TP53- & AR-	graduation	0	414	6	3	2
	futility	0	1	386	405	401
	max_n	0	50	18	19	25
	n	175 (109, 205)	35 (25, 151)	43 (25, 126)	41 (26, 130)	46 (26, 137)
	n_unique	163 (100, 191)	33 (24, 141)	40 (23, 119)	38 (24, 119)	43 (24, 128)
	time_trial	36 (36, 36)	11 (7, 36)	24 (14, 36)	23 (13, 36)	23 (14, 36)
	time_stop	NA (NA, NA)	9 (7, 22)	21 (13, 33)	20 (13, 32)	20 (13, 32)
	post_p	NA (NA, NA)	1 (0.97, 1)	0.02 (0, 0.14)	0.01 (0, 0.12)	0.01 (0, 0.13)
	rate	0.075 (0.066, 0.084)	0.042 (0.032, 0.051)	0.115 (0.096, 0.144)	0.118 (0.097, 0.147)	0.114 (0.096, 0.145)
TP53+	graduation	0	6	0	3	2
	futility	0	31	39	26	26
	max_n	0	4	11	10	7
	n	181 (159, 204)	83 (34, 120)	88 (52, 125)	85 (57, 123)	87 (55, 125)
	n_unique	166 (145, 188)	76 (33, 111)	82 (48, 116)	79 (51, 114)	81 (49, 115)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	15 (10, 30)	19 (13, 27)	20 (13, 33)	20 (13, 34)
	post_p	NA (NA, NA)	0.5 (0.12, 0.9)	0.46 (0.1, 0.88)	0.46 (0.1, 0.86)	0.48 (0.11, 0.89)
	rate	0.111 (0.102, 0.125)	0.112 (0.096, 0.133)	0.115 (0.099, 0.135)	0.114 (0.099, 0.134)	0.112 (0.097, 0.136)
HRD+	graduation	0	5	0	1	1
	futility	0	2	39	58	36
	max_n	0	0	0	0	0
	n	108 (90, 124)	40 (23, 61)	50 (29, 73)	56 (37, 78)	58 (41, 80)
	n_unique	99 (81, 114)	36 (20, 57)	45 (27, 67)	51 (34, 72)	54 (37, 74)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (29, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	20 (19, 25)	26 (18, 33)	20 (13, 32)	21 (12, 31)
	post_p	NA (NA, NA)	0.63 (0.18, 0.97)	0.21 (0.03, 0.64)	0.2 (0.03, 0.68)	0.21 (0.03, 0.68)
	rate	0.096 (0.083, 0.112)	0.09 (0.068, 0.123)	0.115 (0.094, 0.145)	0.114 (0.095, 0.14)	0.112 (0.095, 0.139)
TEfus+	graduation	0	8	3	2	3
	futility	0	6	61	43	40
	max_n	0	1	0	0	0
	n	147 (126, 168)	58 (29, 88)	75 (43, 101)	70 (45, 95)	71 (48, 96)
	n_unique	136 (116, 154)	53 (25, 81)	69 (39, 93)	63 (41, 87)	64 (43, 89)
	time_trial	36 (36, 36)	36 (36, 36)	36 (30, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	20 (13, 27)	20 (10, 34)	24 (15, 32)	25 (13, 34)
	post_p	NA (NA, NA)	0.71 (0.26, 0.97)	0.24 (0.02, 0.66)	0.23 (0.03, 0.7)	0.25 (0.03, 0.73)
	rate	0.1 (0.089, 0.113)	0.092 (0.071, 0.112)	0.114 (0.097, 0.137)	0.114 (0.096, 0.141)	0.112 (0.096, 0.139)

By subgroup combinations:

subtype	var	Control	ARSi	Taxane_CT	Platinum_CT	PARPi
—-	graduation	0	441	396	409	403
	futility	0	0	0	0	0
	max_n	0	50	18	19	25
	n	111 (72, 136)	27 (20, 105)	22 (9, 77)	18 (8, 82)	22 (9, 89)
	n_unique	104 (66, 128)	26 (18, 99)	20 (8, 74)	17 (7, 78)	20 (8, 84)
	post_p	NA (NA, NA)	1 (0.91, 1)	0.08 (0, 0.33)	0.07 (0.01, 0.3)	0.07 (0, 0.3)
	rate	0.075 (0.063, 0.087)	0.042 (0.032, 0.053)	0.115 (0.091, 0.172)	0.119 (0.091, 0.181)	0.117 (0.092, 0.166)
—+	graduation	0	442	404	412	408
	futility	0	0	0	0	0
	max_n	0	50	18	19	25
	n	19 (11, 27)	4 (1, 15)	7 (3, 19)	6 (2, 17)	6 (2, 18)
	n_unique	18 (10, 25)	4 (1, 14)	6 (3, 17)	6 (2, 15)	6 (2, 16)
	post_p	NA (NA, NA)	0.82 (0.5, 0.97)	0.28 (0.1, 0.57)	0.28 (0.1, 0.56)	0.3 (0.11, 0.57)
	rate	0.075 (0.049, 0.11)	0.042 (0.019, 0.085)	0.124 (0.081, 0.238)	0.13 (0.078, 0.3)	0.124 (0.074, 0.291)
–+-	graduation	0	70	42	30	28
	futility	0	0	0	0	0
	max_n	0	4	11	10	7
	n	61 (49, 76)	24 (9, 56)	25 (7, 53)	24 (8, 55)	24 (7, 56)
	n_unique	57 (44, 70)	23 (8, 53)	23 (7, 50)	23 (7, 51)	22 (7, 52)
	post_p	NA (NA, NA)	0.46 (0.11, 0.89)	0.43 (0.11, 0.84)	0.44 (0.12, 0.84)	0.42 (0.11, 0.87)
	rate	0.112 (0.094, 0.134)	0.115 (0.088, 0.182)	0.12 (0.093, 0.212)	0.119 (0.091, 0.198)	0.121 (0.089, 0.21)
–++	graduation	0	82	94	67	63
	futility	0	0	0	0	0
	max_n	0	5	11	10	7
	n	42 (32, 52)	14 (4, 36)	19 (8, 39)	17 (5, 34)	16 (5, 35)
	n_unique	39 (28, 49)	13 (4, 33)	17 (7, 36)	15 (4, 33)	15 (4, 33)
	post_p	NA (NA, NA)	0.44 (0.15, 0.85)	0.44 (0.13, 0.84)	0.46 (0.13, 0.88)	0.44 (0.14, 0.87)
	rate	0.113 (0.091, 0.142)	0.123 (0.085, 0.228)	0.122 (0.091, 0.185)	0.121 (0.085, 0.236)	0.121 (0.085, 0.25)
-+–	graduation	0	441	402	414	408
	futility	0	0	0	0	0
	max_n	0	50	17	19	25
	n	20 (11, 27)	2 (0, 12)	7 (2, 18)	8 (3, 18)	7 (3, 19)
	n_unique	18 (10, 25)	2 (0, 11)	6 (2, 17)	7 (3, 17)	7 (3, 17)
	post_p	NA (NA, NA)	0.77 (0.43, 0.96)	0.28 (0.12, 0.6)	0.27 (0.1, 0.6)	0.27 (0.11, 0.59)
	rate	0.075 (0.053, 0.109)	0.045 (0.012, 0.117)	0.125 (0.078, 0.283)	0.123 (0.079, 0.257)	0.122 (0.081, 0.234)
-+-+	graduation	0	442	408	417	413
	futility	0	0	0	0	0
	max_n	0	50	17	19	25
	n	20 (11, 27)	2 (0, 13)	6 (2, 18)	7 (3, 18)	7 (3, 19)
	n_unique	18 (10, 25)	2 (0, 13)	6 (2, 17)	7 (3, 17)	7 (3, 18)
	post_p	NA (NA, NA)	0.77 (0.44, 0.96)	0.29 (0.11, 0.58)	0.26 (0.1, 0.55)	0.27 (0.1, 0.58)
	rate	0.075 (0.051, 0.11)	0.044 (0.013, 0.12)	0.124 (0.08, 0.286)	0.128 (0.078, 0.271)	0.12 (0.079, 0.236)
-++-	graduation	0	77	73	82	55
	futility	0	0	0	0	0
	max_n	0	4	11	10	7
	n	11 (7, 16)	4 (1, 10)	5 (1, 10)	5 (2, 12)	6 (2, 12)
	n_unique	10 (6, 15)	4 (1, 9)	4 (1, 9)	5 (2, 11)	6 (2, 11)
	post_p	NA (NA, NA)	0.48 (0.24, 0.79)	0.44 (0.22, 0.77)	0.46 (0.22, 0.78)	0.51 (0.22, 0.82)
	rate	0.116 (0.075, 0.186)	0.125 (0.068, 0.363)	0.142 (0.068, 0.39)	0.127 (0.072, 0.327)	0.118 (0.071, 0.283)
-+++	graduation	0	89	120	115	86
	futility	0	0	0	0	0
	max_n	0	5	11	10	7
	n	11 (7, 16)	4 (1, 10)	5 (1, 10)	6 (2, 12)	6 (2, 12)
	n_unique	10 (6, 15)	4 (1, 9)	4 (1, 10)	5 (2, 11)	6 (2, 11)
	post_p	NA (NA, NA)	0.45 (0.24, 0.78)	0.44 (0.24, 0.79)	0.45 (0.21, 0.81)	0.45 (0.21, 0.81)
	rate	0.116 (0.075, 0.182)	0.134 (0.07, 0.363)	0.132 (0.067, 0.408)	0.126 (0.073, 0.308)	0.129 (0.071, 0.325)
+—	graduation	0	33	6	3	1
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	19 (13, 26)	8 (3, 18)	11 (5, 20)	8 (3, 17)	8 (3, 18)
	n_unique	17 (12, 23)	7 (2, 16)	10 (4, 18)	8 (3, 15)	8 (3, 16)
	post_p	NA (NA, NA)	0.45 (0.19, 0.79)	0.49 (0.19, 0.84)	0.46 (0.18, 0.86)	0.48 (0.18, 0.85)
	rate	0.112 (0.084, 0.164)	0.125 (0.08, 0.268)	0.12 (0.081, 0.222)	0.119 (0.075, 0.337)	0.125 (0.07, 0.311)
+–+	graduation	0	47	68	48	44
	futility	0	0	0	0	0
	max_n	0	1	0	0	0
	n	16 (10, 21)	7 (2, 15)	8 (4, 16)	6 (2, 13)	7 (2, 15)
	n_unique	14 (9, 20)	6 (2, 14)	8 (3, 16)	6 (2, 13)	6 (2, 14)
	post_p	NA (NA, NA)	0.48 (0.21, 0.85)	0.48 (0.18, 0.82)	0.45 (0.2, 0.8)	0.44 (0.21, 0.82)
	rate	0.116 (0.075, 0.17)	0.121 (0.071, 0.299)	0.123 (0.081, 0.254)	0.129 (0.067, 0.321)	0.124 (0.072, 0.317)
+-+-	graduation	0	70	42	30	28
	futility	0	0	0	0	0
	max_n	0	4	11	10	7
	n	15 (10, 21)	6 (2, 14)	8 (3, 15)	7 (3, 14)	7 (2, 15)
	n_unique	14 (9, 20)	5 (2, 13)	7 (2, 14)	6 (3, 13)	6 (2, 14)
	post_p	NA (NA, NA)	0.47 (0.2, 0.83)	0.47 (0.2, 0.8)	0.45 (0.2, 0.83)	0.47 (0.23, 0.82)
	rate	0.116 (0.081, 0.165)	0.122 (0.072, 0.323)	0.119 (0.076, 0.267)	0.125 (0.074, 0.273)	0.127 (0.07, 0.292)
+-++	graduation	0	82	94	67	63
	futility	0	0	0	0	0
	max_n	0	5	11	10	7
	n	16 (10, 22)	6 (2, 14)	8 (3, 16)	7 (2, 15)	7 (2, 16)
	n_unique	14 (9, 20)	5 (1, 13)	7 (2, 15)	6 (2, 13)	6 (2, 14)
	post_p	NA (NA, NA)	0.45 (0.19, 0.84)	0.48 (0.2, 0.82)	0.42 (0.19, 0.83)	0.48 (0.21, 0.84)
	rate	0.116 (0.081, 0.169)	0.128 (0.073, 0.358)	0.122 (0.076, 0.272)	0.135 (0.076, 0.335)	0.12 (0.073, 0.348)
++–	graduation	0	40	44	60	37
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	11 (7, 16)	5 (1, 10)	5 (2, 11)	6 (2, 11)	6 (3, 11)
	n_unique	10 (6, 15)	4 (1, 9)	5 (2, 10)	5 (2, 11)	5 (2, 11)
	post_p	NA (NA, NA)	0.45 (0.24, 0.82)	0.46 (0.23, 0.81)	0.46 (0.21, 0.79)	0.47 (0.21, 0.83)
	rate	0.114 (0.077, 0.187)	0.127 (0.066, 0.316)	0.124 (0.067, 0.288)	0.125 (0.073, 0.306)	0.123 (0.07, 0.28)
++-+	graduation	0	54	99	97	72
	futility	0	0	0	0	0
	max_n	0	1	0	0	0
	n	11 (6, 16)	5 (1, 10)	5 (2, 11)	6 (2, 12)	5 (2, 13)
	n_unique	10 (6, 15)	4 (1, 10)	4 (1, 10)	5 (2, 11)	5 (2, 12)
	post_p	NA (NA, NA)	0.47 (0.24, 0.78)	0.47 (0.23, 0.8)	0.46 (0.21, 0.8)	0.47 (0.21, 0.8)
	rate	0.114 (0.074, 0.183)	0.127 (0.068, 0.297)	0.13 (0.066, 0.37)	0.131 (0.075, 0.338)	0.128 (0.073, 0.309)
+++-	graduation	0	77	73	82	55
	futility	0	0	0	0	0
	max_n	0	4	11	10	7
	n	11 (6, 16)	5 (1, 11)	5 (2, 11)	6 (2, 12)	6 (2, 12)
	n_unique	10 (6, 15)	4 (1, 10)	5 (1, 10)	6 (2, 11)	5 (2, 12)
	post_p	NA (NA, NA)	0.47 (0.22, 0.83)	0.44 (0.22, 0.81)	0.45 (0.21, 0.77)	0.46 (0.2, 0.79)
	rate	0.113 (0.071, 0.18)	0.128 (0.065, 0.348)	0.134 (0.065, 0.349)	0.129 (0.076, 0.329)	0.13 (0.072, 0.327)
++++	graduation	0	89	120	115	86
	futility	0	0	0	0	0
	max_n	0	5	11	10	7
	n	11 (7, 17)	5 (1, 11)	5 (1, 11)	6 (2, 12)	6 (2, 11)
	n_unique	10 (6, 15)	4 (1, 10)	4 (1, 10)	6 (2, 11)	5 (2, 11)
	post_p	NA (NA, NA)	0.47 (0.23, 0.83)	0.44 (0.23, 0.79)	0.48 (0.23, 0.81)	0.46 (0.22, 0.8)
	rate	0.114 (0.075, 0.186)	0.125 (0.063, 0.348)	0.13 (0.067, 0.383)	0.124 (0.071, 0.271)	0.124 (0.072, 0.306)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	ARSi	Taxane_CT	Platinum_CT	PARPi
all	count	29	2	1
	time_stop	5 (4, 8)	6 (5, 7)	6 (6, 6)
	n_trt	34 (27, 49)	30 (26, 35)	31 (31, 31)
	n_control	51 (43, 77)	66 (56, 77)	57 (57, 57)
	post_p	0.95 (0.87, 0.99)	0.94 (0.9, 0.98)	0.9 (0.9, 0.9)
	order	1 (1, 1.2)	1 (1, 1)	1 (1, 1)
TP53- & AR-	count	414	6	3	2
	time_stop	10 (7, 22)	12 (10, 14)	12 (11, 13)	12 (11, 14)
	n_trt	34 (26, 90)	29 (27, 37)	28 (26, 30)	28 (28, 29)
	n_control	41 (27, 101)	48 (46, 56)	36 (35, 41)	64 (53, 76)
	post_p	0.95 (0.88, 1)	0.91 (0.89, 0.95)	0.88 (0.86, 0.92)	0.92 (0.87, 0.98)
	order	1 (1, 1)	1.5 (1, 2)	1 (1, 1.8)	2 (2, 2)
TP53+	count	6		3	2
	time_stop	10 (10, 14)		17 (12, 31)	16 (14, 18)
	n_trt	36 (30, 48)		44 (34, 108)	34 (30, 38)
	n_control	48 (43, 62)		82 (47, 148)	79 (70, 88)
	post_p	0.97 (0.93, 0.98)		0.99 (0.99, 1)	0.94 (0.93, 0.95)
	order	2 (1, 2)		2 (1.2, 2)	2 (2, 2)
HRD+	count	5		1	1
	time_stop	20 (19, 22)		15 (15, 15)	11 (11, 11)
	n_trt	28 (27, 37)		25 (25, 25)	25 (25, 25)
	n_control	56 (49, 71)		42 (42, 42)	26 (26, 26)
	post_p	0.98 (0.92, 0.99)		1 (1, 1)	0.94 (0.94, 0.94)
	order	2 (1.4, 2)		2 (2, 2)	2 (2, 2)
TEfus+	count	8	3	2	3
	time_stop	20 (16, 25)	8 (6, 13)	12 (11, 12)	11 (11, 14)
	n_trt	36 (26, 50)	26 (25, 33)	28 (28, 28)	27 (26, 28)
	n_control	78 (60, 98)	30 (26, 44)	37 (31, 43)	45 (39, 48)
	post_p	0.98 (0.93, 1)	0.96 (0.94, 0.98)	0.99 (0.98, 0.99)	0.93 (0.89, 0.98)
	order	2 (1.7, 2.3)	2 (1.2, 2.8)	1.5 (1.1, 1.9)	2 (2, 2)

Futility:

signature	var	ARSi	Taxane_CT	Platinum_CT	PARPi
all	count	4	4	2	1
	time_stop	4 (3, 4)	16 (9, 27)	24 (20, 28)	22 (22, 22)
	n_trt	28 (27, 29)	72 (47, 103)	83 (71, 95)	84 (84, 84)
	n_control	38 (33, 42)	186 (95, 292)	250 (234, 266)	249 (249, 249)
	post_p	0.25 (0.19, 0.27)	0.02 (0, 0.03)	0.01 (0, 0.02)	0.01 (0.01, 0.01)
	order	1 (1, 1)	3 (1.3, 5.4)	4.5 (3.3, 5.7)	3 (3, 3)
TP53- & AR-	count	1	386	405	401
	time_stop	9 (9, 9)	21 (13, 33)	20 (13, 32)	20 (13, 32)
	n_trt	25 (25, 25)	37 (25, 100)	35 (25, 96)	39 (25, 94)
	n_control	26 (26, 26)	100 (57, 170)	100 (56, 165)	96 (54, 164)
	post_p	0.26 (0.26, 0.26)	0.06 (0, 0.2)	0.05 (0, 0.19)	0.06 (0, 0.19)
	order	1 (1, 1)	2 (1, 4)	2 (1, 4)	2 (1, 4)
TP53+	count	31	39	26	26
	time_stop	16 (10, 30)	19 (13, 27)	20 (13, 32)	22 (13, 34)
	n_trt	36 (25, 70)	41 (27, 68)	40 (25, 62)	43 (26, 58)
	n_control	79 (37, 147)	90 (51, 128)	87 (52, 152)	104 (62, 170)
	post_p	0.05 (0.02, 0.15)	0.08 (0.04, 0.22)	0.06 (0.01, 0.16)	0.04 (0, 0.14)
	order	1 (1, 4)	2 (1, 4)	2.5 (1, 5)	2 (1, 5)
HRD+	count	2	39	58	36
	time_stop	24 (21, 28)	26 (18, 33)	20 (13, 32)	21 (12, 31)
	n_trt	28 (26, 30)	29 (25, 46)	36 (26, 50)	32 (25, 63)
	n_control	78 (61, 95)	75 (47, 107)	58 (30, 95)	59 (28, 99)
	post_p	0.04 (0.04, 0.04)	0.04 (0, 0.16)	0.04 (0, 0.15)	0.04 (0, 0.19)
	order	3 (2.2, 3.8)	3 (2, 4.2)	3 (1, 4.3)	3 (1, 4.5)
TEfus+	count	6	61	43	40
	time_stop	20 (12, 26)	21 (11, 34)	24 (16, 33)	26 (15, 34)
	n_trt	30 (25, 37)	41 (26, 70)	39 (26, 58)	47 (28, 78)
	n_control	90 (42, 114)	82 (40, 129)	96 (60, 131)	108 (53, 137)
	post_p	0.06 (0.02, 0.11)	0.04 (0, 0.15)	0.04 (0.01, 0.14)	0.05 (0.01, 0.12)
	order	2 (1, 3.5)	3 (1, 5)	3 (1.2, 5)	4 (2, 6)

By subgroup combinations

Graduation:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	ARSi	count	29	29	29	29	29	29	29	29	29	29	29	29	29	29	29	29
		time	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)
		n	17 (11, 25)	2 (1, 5)	8 (4, 11)	3 (0, 5)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	1 (0, 3)	1 (0, 2)	0 (0, 3)	0 (0, 2)	0 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 1)
		post_p	0.66 (0.56, 0.9)	0.55 (0.51, 0.64)	0.59 (0.52, 0.71)	0.55 (0.52, 0.66)	0.57 (0.54, 0.59)	0.53 (0.51, 0.6)	0.58 (0.53, 0.72)	0.52 (0.5, 0.54)	0.54 (0.52, 0.58)	0.54 (0.52, 0.58)	0.56 (0.53, 0.57)	0.52 (0.51, 0.6)	0.54 (0.52, 0.58)	0.52 (0.52, 0.6)	0.54 (0.53, 0.62)	0.55 (0.53, 0.57)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.027 (0.005, 0.061)	0 (0, 0.021)	0.08 (0, 0.113)	0 (0, 0.104)	0 (0, 0.027)	0 (0, 0)	0 (0, 0.137)	0 (0, 1.004)	0 (0, 0.083)	0 (0, 0.271)	0 (0, 0.064)	0 (0, 0)	0 (0, 0.01)	0 (0, 0.05)	0 (0, 0)	0 (0, 0.313)
	Taxane_CT	count	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
		time	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)
		n	3 (1, 5)	2 (0, 3)	4 (3, 4)	6 (5, 7)	0 (0, 1)	0 (0, 0)	0 (0, 1)	1 (0, 2)	3 (2, 4)	4 (2, 6)	2 (2, 2)	4 (4, 5)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 1)
		post_p	0.62 (0.62, 0.62)	0.58 (0.58, 0.58)	0.56 (0.55, 0.57)	0.55 (0.53, 0.58)	0.55 (0.55, 0.55)	NA (NA, NA)	0.55 (0.55, 0.55)	0.52 (0.52, 0.52)	0.54 (0.53, 0.55)	0.6 (0.55, 0.65)	0.57 (0.53, 0.61)	0.58 (0.58, 0.58)	0.54 (0.54, 0.54)	NA (NA, NA)	0.52 (0.52, 0.52)	0.53 (0.53, 0.53)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0 (0, 0)	0 (0, 0)	0.055 (0.011, 0.099)	0.048 (0.01, 0.087)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0.035 (0.007, 0.063)	0.019 (0.004, 0.034)	0 (0, 0)	0.065 (0.013, 0.117)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)
	Platinum_CT	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
		time	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)
		n	8 (8, 8)	0 (0, 0)	5 (5, 5)	0 (0, 0)	1 (1, 1)	6 (6, 6)	2 (2, 2)	1 (1, 1)	2 (2, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	2 (2, 2)	1 (1, 1)	2 (2, 2)	1 (1, 1)
		post_p	0.67 (0.67, 0.67)	NA (NA, NA)	0.56 (0.56, 0.56)	NA (NA, NA)	NA (NA, NA)	0.56 (0.56, 0.56)	0.52 (0.52, 0.52)	0.57 (0.57, 0.57)	0.51 (0.51, 0.51)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.55 (0.55, 0.55)	NA (NA, NA)	0.56 (0.56, 0.56)	0.57 (0.57, 0.57)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0 (0, 0)	NA (NA, NA)	0.06 (0.06, 0.06)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.308 (0.308, 0.308)	0.922 (0.922, 0.922)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53- & AR-	ARSi	count	414	414			414	414
		time	10 (7, 22)	10 (7, 22)			10 (7, 22)	10 (7, 22)
		n	26 (20, 64)	4 (1, 11)			2 (0, 8)	2 (0, 8)
		post_p	0.87 (0.74, 1)	0.6 (0.52, 0.8)			0.58 (0.51, 0.86)	0.58 (0.51, 0.84)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.037 (0.016, 0.056)	0.017 (0, 0.074)			0 (0, 0.073)	0 (0, 0.07)
	Taxane_CT	count	6	6			6	6
		time	12 (10, 14)	12 (10, 14)			12 (10, 14)	12 (10, 14)
		n	23 (18, 28)	4 (1, 5)			2 (0, 6)	2 (0, 4)
		post_p	0.76 (0.75, 0.91)	0.61 (0.52, 0.75)			0.61 (0.56, 0.7)	0.56 (0.53, 0.58)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.053 (0.031, 0.076)	0.014 (0, 0.045)			0 (0, 0.029)	0 (0, 0.081)
	Platinum_CT	count	3	3			3	3
		time	12 (11, 13)	12 (11, 13)			12 (11, 13)	12 (11, 13)
		n	16 (14, 18)	4 (3, 5)			5 (3, 5)	3 (3, 5)
		post_p	0.84 (0.84, 0.84)	0.61 (0.54, 0.61)			0.61 (0.57, 0.66)	0.55 (0.52, 0.68)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.033 (0.03, 0.035)	0.055 (0.011, 0.088)			0.067 (0.037, 0.072)	0.083 (0.036, 0.1)
	PARPi	count	2	2			2	2
		time	12 (11, 14)	12 (11, 14)			12 (11, 14)	12 (11, 14)
		n	10 (5, 16)	4 (4, 5)			6 (4, 8)	8 (6, 10)
		post_p	0.66 (0.62, 0.71)	0.66 (0.65, 0.67)			0.65 (0.56, 0.75)	0.64 (0.57, 0.7)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.053 (0.039, 0.067)	0 (0, 0)			0.054 (0.011, 0.098)	0.04 (0.035, 0.044)
TP53+	ARSi	count			6	6			6	6			6	6			6	6
		time			10 (10, 14)	10 (10, 14)			10 (10, 14)	10 (10, 14)			10 (10, 14)	10 (10, 14)			10 (10, 14)	10 (10, 14)
		n			18 (13, 20)	6 (4, 10)			2 (2, 4)	2 (0, 4)			3 (1, 4)	2 (0, 6)			2 (0, 5)	2 (0, 5)
		post_p			0.79 (0.71, 0.86)	0.72 (0.63, 0.89)			0.59 (0.54, 0.69)	0.63 (0.55, 0.78)			0.55 (0.52, 0.6)	0.58 (0.52, 0.8)			0.57 (0.54, 0.58)	0.6 (0.56, 0.8)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.076 (0.049, 0.09)	0.048 (0.038, 0.093)			0 (0, 0.087)	0.013 (0, 0.066)			0.033 (0, 0.125)	0.051 (0, 0.095)			0.125 (0, 0.192)	0.088 (0.018, 0.09)
	Platinum_CT	count			3	3			3	3			3	3			3	3
		time			17 (12, 31)	17 (12, 31)			17 (12, 31)	17 (12, 31)			17 (12, 31)	17 (12, 31)			17 (12, 31)	17 (12, 31)
		n			16 (10, 38)	7 (5, 25)			4 (4, 5)	5 (3, 5)			4 (3, 9)	1 (1, 19)			4 (2, 7)	4 (2, 4)
		post_p			0.8 (0.79, 0.82)	0.82 (0.79, 0.83)			0.54 (0.53, 0.6)	0.58 (0.55, 0.79)			0.65 (0.64, 0.7)	0.62 (0.55, 0.9)			0.79 (0.59, 0.82)	0.62 (0.54, 0.66)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.083 (0.074, 0.092)	0.083 (0.017, 0.097)			0.128 (0.098, 0.19)	0.069 (0.044, 0.104)			0.033 (0.007, 0.093)	0 (0, 0.066)			0.044 (0.009, 0.05)	0.105 (0.021, 0.132)
	PARPi	count			2	2			2	2			2	2			2	2
		time			16 (14, 18)	16 (14, 18)			16 (14, 18)	16 (14, 18)			16 (14, 18)	16 (14, 18)			16 (14, 18)	16 (14, 18)
		n			10 (8, 11)	6 (6, 6)			4 (3, 6)	2 (2, 3)			4 (2, 6)	1 (0, 2)			2 (1, 4)	4 (4, 5)
		post_p			0.8 (0.75, 0.85)	0.75 (0.72, 0.78)			0.65 (0.59, 0.71)	0.54 (0.53, 0.54)			0.67 (0.56, 0.78)	0.56 (0.56, 0.56)			0.53 (0.51, 0.56)	0.71 (0.68, 0.73)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.056 (0.049, 0.063)	0.031 (0.006, 0.056)			0.088 (0.065, 0.112)	0.133 (0.12, 0.147)			0.035 (0.007, 0.064)	0.117 (0.117, 0.117)			0.03 (0.006, 0.054)	0.097 (0.056, 0.138)
HRD+	ARSi	count					5	5	5	5					5	5	5	5
		time					20 (19, 22)	20 (19, 22)	20 (19, 22)	20 (19, 22)					20 (19, 22)	20 (19, 22)	20 (19, 22)	20 (19, 22)
		n					1 (0, 3)	4 (2, 7)	4 (3, 9)	3 (1, 6)					3 (1, 6)	4 (1, 8)	5 (4, 7)	3 (1, 6)
		post_p					0.52 (0.51, 0.71)	0.75 (0.58, 0.86)	0.79 (0.72, 0.83)	0.66 (0.53, 0.74)					0.59 (0.53, 0.72)	0.58 (0.56, 0.86)	0.65 (0.64, 0.78)	0.66 (0.55, 0.85)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.056 (0.011, 0.088)	0.024 (0.009, 0.083)	0.033 (0.012, 0.08)	0.064 (0.012, 0.108)					0.071 (0.025, 0.092)	0 (0, 0.068)	0.057 (0.055, 0.072)	0.022 (0, 0.09)
	Platinum_CT	count					1	1	1	1					1	1	1	1
		time					15 (15, 15)	15 (15, 15)	15 (15, 15)	15 (15, 15)					15 (15, 15)	15 (15, 15)	15 (15, 15)	15 (15, 15)
		n					5 (5, 5)	7 (7, 7)	0 (0, 0)	4 (4, 4)					5 (5, 5)	2 (2, 2)	1 (1, 1)	1 (1, 1)
		post_p					0.62 (0.62, 0.62)	0.85 (0.85, 0.85)	NA (NA, NA)	0.82 (0.82, 0.82)					0.8 (0.8, 0.8)	0.6 (0.6, 0.6)	0.6 (0.6, 0.6)	0.57 (0.57, 0.57)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.072 (0.072, 0.072)	0.022 (0.022, 0.022)	NA (NA, NA)	0.035 (0.035, 0.035)					0.025 (0.025, 0.025)	0.115 (0.115, 0.115)	0 (0, 0)	0 (0, 0)
	PARPi	count					1	1	1	1					1	1	1	1
		time					11 (11, 11)	11 (11, 11)	11 (11, 11)	11 (11, 11)					11 (11, 11)	11 (11, 11)	11 (11, 11)	11 (11, 11)
		n					2 (2, 2)	3 (3, 3)	2 (2, 2)	3 (3, 3)					5 (5, 5)	3 (3, 3)	3 (3, 3)	4 (4, 4)
		post_p					0.61 (0.61, 0.61)	0.59 (0.59, 0.59)	0.55 (0.55, 0.55)	0.52 (0.52, 0.52)					0.58 (0.58, 0.58)	0.56 (0.56, 0.56)	0.58 (0.58, 0.58)	0.66 (0.66, 0.66)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0 (0, 0)	0 (0, 0)	0 (0, 0)	0.128 (0.128, 0.128)					0.036 (0.036, 0.036)	0 (0, 0)	0 (0, 0)	0.094 (0.094, 0.094)
TEfus+	ARSi	count		8		8		8		8		8		8		8		8
		time		20 (16, 25)		20 (16, 25)		20 (16, 25)		20 (16, 25)		20 (16, 25)		20 (16, 25)		20 (16, 25)		20 (16, 25)
		n		4 (2, 8)		12 (8, 15)		3 (0, 5)		4 (1, 5)		4 (2, 6)		4 (1, 11)		4 (1, 8)		4 (1, 5)
		post_p		0.77 (0.6, 0.93)		0.82 (0.71, 0.88)		0.81 (0.67, 0.91)		0.62 (0.5, 0.75)		0.6 (0.53, 0.72)		0.58 (0.51, 0.8)		0.71 (0.57, 0.79)		0.56 (0.53, 0.78)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.035 (0, 0.07)		0.083 (0.05, 0.088)		0.007 (0, 0.041)		0.062 (0.037, 0.111)		0.089 (0.06, 0.105)		0.088 (0, 0.135)		0 (0, 0.094)		0.079 (0, 0.095)
	Taxane_CT	count		3		3		3		3		3		3		3		3
		time		8 (6, 13)		8 (6, 13)		8 (6, 13)		8 (6, 13)		8 (6, 13)		8 (6, 13)		8 (6, 13)		8 (6, 13)
		n		1 (0, 3)		14 (11, 19)		1 (0, 3)		1 (0, 3)		4 (4, 4)		3 (3, 5)		0 (0, 2)		1 (0, 2)
		post_p		0.6 (0.52, 0.67)		0.8 (0.77, 0.83)		0.53 (0.53, 0.53)		0.6 (0.57, 0.63)		0.54 (0.51, 0.65)		0.54 (0.52, 0.58)		0.64 (0.64, 0.64)		0.59 (0.59, 0.59)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0.038 (0.008, 0.068)		0.051 (0.028, 0.082)		0.072 (0.014, 0.13)		0 (0, 0)		0 (0, 0.037)		0.065 (0.039, 0.079)		0 (0, 0)		0 (0, 0)
	Platinum_CT	count		2		2		2		2		2		2		2		2
		time		12 (11, 12)		12 (11, 12)		12 (11, 12)		12 (11, 12)		12 (11, 12)		12 (11, 12)		12 (11, 12)		12 (11, 12)
		n		4 (4, 5)		8 (8, 9)		7 (5, 9)		2 (2, 2)		2 (0, 3)		0 (0, 0)		3 (3, 3)		2 (0, 3)
		post_p		0.62 (0.6, 0.64)		0.79 (0.75, 0.83)		0.71 (0.63, 0.78)		0.61 (0.6, 0.61)		0.6 (0.6, 0.6)		NA (NA, NA)		0.54 (0.53, 0.55)		0.68 (0.68, 0.68)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.024 (0.005, 0.043)		0.043 (0.037, 0.048)		0.035 (0.026, 0.043)		0.027 (0.005, 0.048)		0 (0, 0)		NA (NA, NA)		0.057 (0.049, 0.065)		0 (0, 0)
	PARPi	count		3		3		3		3		3		3		3		3
		time		11 (11, 14)		11 (11, 14)		11 (11, 14)		11 (11, 14)		11 (11, 14)		11 (11, 14)		11 (11, 14)		11 (11, 14)
		n		1 (1, 6)		4 (3, 6)		5 (5, 5)		2 (2, 6)		3 (1, 4)		1 (1, 3)		3 (3, 5)		3 (2, 5)
		post_p		0.61 (0.54, 0.8)		0.64 (0.6, 0.74)		0.54 (0.51, 0.62)		0.73 (0.66, 0.82)		0.68 (0.6, 0.75)		0.57 (0.56, 0.58)		0.65 (0.56, 0.72)		0.56 (0.52, 0.66)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0 (0, 0.049)		0.043 (0.009, 0.097)		0.08 (0.016, 0.101)		0 (0, 0.099)		0 (0, 0)		0 (0, 0)		0.062 (0.058, 0.105)		0.071 (0.014, 0.082)

Futility:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	ARSi	count	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4
		time	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)
		n	14 (12, 17)	3 (1, 5)	6 (5, 6)	3 (2, 3)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	2 (1, 2)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)
		post_p	0.44 (0.37, 0.48)	0.42 (0.4, 0.43)	0.44 (0.39, 0.47)	0.42 (0.38, 0.47)	NA (NA, NA)	0.48 (0.48, 0.48)	NA (NA, NA)	NA (NA, NA)	0.44 (0.43, 0.47)	NA (NA, NA)	0.41 (0.41, 0.41)	0.48 (0.48, 0.48)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.47 (0.47, 0.47)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.076 (0.05, 0.094)	0.056 (0, 0.256)	0.232 (0.205, 0.25)	0.208 (0.054, 1.418)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0.095 (0, 0.588)	NA (NA, NA)	1.414 (1.414, 1.414)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)
	Taxane_CT	count	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4
		time	16 (9, 27)	16 (9, 27)	16 (9, 27)	16 (9, 27)	16 (9, 27)	16 (9, 27)	16 (9, 27)	16 (9, 27)	16 (9, 27)	16 (9, 27)	16 (9, 27)	16 (9, 27)	16 (9, 27)	16 (9, 27)	16 (9, 27)	16 (9, 27)
		n	12 (6, 32)	4 (2, 6)	6 (3, 9)	8 (7, 12)	4 (0, 10)	4 (1, 6)	2 (1, 3)	0 (0, 1)	8 (6, 12)	6 (5, 7)	6 (4, 7)	2 (1, 4)	2 (2, 3)	0 (0, 2)	1 (0, 2)	2 (0, 3)
		post_p	0.11 (0.02, 0.16)	0.35 (0.27, 0.36)	0.33 (0.2, 0.43)	0.44 (0.44, 0.46)	0.37 (0.32, 0.45)	0.42 (0.3, 0.48)	0.33 (0.26, 0.36)	0.4 (0.4, 0.4)	0.4 (0.32, 0.43)	0.45 (0.21, 0.49)	0.4 (0.19, 0.44)	0.36 (0.35, 0.45)	0.41 (0.29, 0.48)	0.4 (0.36, 0.44)	0.4 (0.35, 0.44)	0.28 (0.21, 0.44)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.16 (0.126, 0.387)	0.151 (0.118, 0.547)	0.18 (0.168, 0.243)	0.102 (0.099, 0.131)	0.134 (0.116, 0.293)	0.095 (0.06, 0.232)	0.312 (0.2, 0.332)	0.467 (0.467, 0.467)	0.13 (0.107, 0.169)	0.127 (0.094, 0.504)	0.109 (0.094, 0.534)	0.162 (0.111, 0.269)	0.238 (0.196, 0.313)	0.469 (0.267, 0.672)	0.31 (0.281, 0.339)	0.514 (0.151, 1.106)
	Platinum_CT	count	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
		time	24 (20, 28)	24 (20, 28)	24 (20, 28)	24 (20, 28)	24 (20, 28)	24 (20, 28)	24 (20, 28)	24 (20, 28)	24 (20, 28)	24 (20, 28)	24 (20, 28)	24 (20, 28)	24 (20, 28)	24 (20, 28)	24 (20, 28)	24 (20, 28)
		n	26 (13, 38)	7 (6, 8)	10 (8, 13)	2 (1, 4)	10 (8, 12)	2 (1, 2)	2 (1, 3)	2 (2, 3)	4 (4, 4)	2 (2, 3)	2 (1, 4)	2 (1, 4)	2 (2, 3)	2 (2, 3)	2 (1, 3)	3 (3, 3)
		post_p	0.18 (0.09, 0.27)	0.14 (0.1, 0.18)	0.41 (0.35, 0.46)	0.31 (0.24, 0.39)	0.27 (0.15, 0.39)	0.3 (0.29, 0.31)	0.33 (0.27, 0.38)	0.4 (0.35, 0.44)	0.35 (0.3, 0.39)	0.35 (0.3, 0.39)	0.22 (0.22, 0.22)	0.28 (0.28, 0.28)	0.41 (0.34, 0.48)	0.32 (0.31, 0.33)	0.37 (0.3, 0.45)	0.4 (0.32, 0.48)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.13 (0.107, 0.152)	0.222 (0.147, 0.298)	0.122 (0.118, 0.127)	0.291 (0.235, 0.348)	0.14 (0.126, 0.155)	0.611 (0.263, 0.958)	0.321 (0.238, 0.405)	0.171 (0.082, 0.259)	0.193 (0.179, 0.208)	0.391 (0.208, 0.574)	0.25 (0.25, 0.25)	0.175 (0.175, 0.175)	0.186 (0.109, 0.262)	0.32 (0.303, 0.338)	0.285 (0.247, 0.322)	0.162 (0.108, 0.216)
	PARPi	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
		time	22 (22, 22)	22 (22, 22)	22 (22, 22)	22 (22, 22)	22 (22, 22)	22 (22, 22)	22 (22, 22)	22 (22, 22)	22 (22, 22)	22 (22, 22)	22 (22, 22)	22 (22, 22)	22 (22, 22)	22 (22, 22)	22 (22, 22)	22 (22, 22)
		n	25 (25, 25)	1 (1, 1)	12 (12, 12)	1 (1, 1)	11 (11, 11)	9 (9, 9)	1 (1, 1)	4 (4, 4)	2 (2, 2)	3 (3, 3)	3 (3, 3)	1 (1, 1)	5 (5, 5)	3 (3, 3)	2 (2, 2)	1 (1, 1)
		post_p	0.24 (0.24, 0.24)	0.36 (0.36, 0.36)	0.33 (0.33, 0.33)	0.31 (0.31, 0.31)	0.45 (0.45, 0.45)	0.35 (0.35, 0.35)	0.42 (0.42, 0.42)	0.35 (0.35, 0.35)	0.36 (0.36, 0.36)	0.39 (0.39, 0.39)	0.29 (0.29, 0.29)	0.42 (0.42, 0.42)	0.36 (0.36, 0.36)	0.49 (0.49, 0.49)	0.23 (0.23, 0.23)	0.38 (0.38, 0.38)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.107 (0.107, 0.107)	30.678 (30.678, 30.678)	0.145 (0.145, 0.145)	1.506 (1.506, 1.506)	0.082 (0.082, 0.082)	0.139 (0.139, 0.139)	0.221 (0.221, 0.221)	0.153 (0.153, 0.153)	0.575 (0.575, 0.575)	0.175 (0.175, 0.175)	0.268 (0.268, 0.268)	0.287 (0.287, 0.287)	0.112 (0.112, 0.112)	0.166 (0.166, 0.166)	0.326 (0.326, 0.326)	0.64 (0.64, 0.64)
TP53- & AR-	ARSi	count	1	1			1	1
		time	9 (9, 9)	9 (9, 9)			9 (9, 9)	9 (9, 9)
		n	18 (18, 18)	3 (3, 3)			1 (1, 1)	3 (3, 3)
		post_p	0.45 (0.45, 0.45)	0.45 (0.45, 0.45)			0.38 (0.38, 0.38)	0.47 (0.47, 0.47)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.087 (0.087, 0.087)	0.063 (0.063, 0.063)			0.214 (0.214, 0.214)	0.153 (0.153, 0.153)
	Taxane_CT	count	386	386			386	386
		time	21 (13, 33)	21 (13, 33)			21 (13, 33)	21 (13, 33)
		n	20 (9, 59)	6 (3, 15)			6 (2, 15)	6 (2, 16)
		post_p	0.19 (0.03, 0.43)	0.34 (0.15, 0.48)			0.38 (0.17, 0.48)	0.38 (0.17, 0.48)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.114 (0.088, 0.176)	0.131 (0.082, 0.258)			0.134 (0.086, 0.298)	0.131 (0.084, 0.325)
	Platinum_CT	count	405	405			405	405
		time	20 (13, 32)	20 (13, 32)			20 (13, 32)	20 (13, 32)
		n	17 (8, 59)	6 (2, 14)			7 (3, 15)	7 (3, 15)
		post_p	0.19 (0.02, 0.45)	0.38 (0.16, 0.48)			0.34 (0.12, 0.48)	0.34 (0.15, 0.48)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.118 (0.09, 0.198)	0.137 (0.083, 0.328)			0.127 (0.085, 0.277)	0.128 (0.088, 0.287)
	PARPi	count	401	401			401	401
		time	20 (13, 32)	20 (13, 32)			20 (13, 32)	20 (13, 32)
		n	19 (9, 63)	5 (2, 14)			7 (3, 15)	7 (3, 16)
		post_p	0.21 (0.03, 0.43)	0.38 (0.2, 0.48)			0.36 (0.18, 0.48)	0.37 (0.17, 0.48)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.116 (0.087, 0.175)	0.128 (0.081, 0.344)			0.126 (0.078, 0.247)	0.122 (0.082, 0.25)
TP53+	ARSi	count			31	31			31	31			31	31			31	31
		time			16 (10, 30)	16 (10, 30)			16 (10, 30)	16 (10, 30)			16 (10, 30)	16 (10, 30)			16 (10, 30)	16 (10, 30)
		n			13 (8, 26)	7 (4, 16)			2 (0, 5)	2 (1, 5)			4 (1, 6)	4 (0, 5)			2 (0, 5)	2 (1, 7)
		post_p			0.24 (0.11, 0.45)	0.34 (0.18, 0.47)			0.43 (0.32, 0.48)	0.38 (0.25, 0.49)			0.4 (0.29, 0.48)	0.4 (0.15, 0.45)			0.41 (0.19, 0.46)	0.43 (0.32, 0.48)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.14 (0.108, 0.182)	0.148 (0.107, 0.293)			0.167 (0.109, 1.08)	0.194 (0.08, 1.276)			0.154 (0.108, 0.415)	0.163 (0.093, 0.385)			0.268 (0.114, 0.574)	0.165 (0.058, 0.871)
	Taxane_CT	count			39	39			39	39			39	39			39	39
		time			19 (13, 27)	19 (13, 27)			19 (13, 27)	19 (13, 27)			19 (13, 27)	19 (13, 27)			19 (13, 27)	19 (13, 27)
		n			10 (5, 34)	10 (6, 17)			2 (0, 4)	2 (0, 5)			5 (2, 7)	3 (2, 8)			2 (0, 5)	2 (0, 5)
		post_p			0.34 (0.15, 0.47)	0.36 (0.14, 0.45)			0.37 (0.22, 0.47)	0.4 (0.28, 0.49)			0.4 (0.23, 0.47)	0.38 (0.27, 0.47)			0.41 (0.27, 0.49)	0.42 (0.23, 0.49)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.136 (0.098, 0.281)	0.13 (0.104, 0.205)			0.234 (0.109, 0.456)	0.237 (0.096, 0.897)			0.169 (0.088, 0.335)	0.162 (0.102, 0.517)			0.194 (0.101, 0.792)	0.256 (0.098, 0.611)
	Platinum_CT	count			26	26			26	26			26	26			26	26
		time			20 (13, 32)	20 (13, 32)			20 (13, 32)	20 (13, 32)			20 (13, 32)	20 (13, 32)			20 (13, 32)	20 (13, 32)
		n			13 (6, 20)	5 (2, 16)			3 (1, 5)	3 (2, 6)			4 (2, 11)	2 (1, 5)			4 (0, 9)	3 (1, 7)
		post_p			0.35 (0.11, 0.43)	0.4 (0.14, 0.48)			0.39 (0.24, 0.48)	0.38 (0.18, 0.46)			0.36 (0.24, 0.49)	0.37 (0.2, 0.46)			0.37 (0.28, 0.47)	0.4 (0.25, 0.49)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.146 (0.113, 0.224)	0.142 (0.104, 0.402)			0.225 (0.095, 1.059)	0.174 (0.114, 0.274)			0.185 (0.104, 0.505)	0.178 (0.126, 0.436)			0.17 (0.101, 0.347)	0.174 (0.1, 0.293)
	PARPi	count			26	26			26	26			26	26			26	26
		time			22 (13, 34)	22 (13, 34)			22 (13, 34)	22 (13, 34)			22 (13, 34)	22 (13, 34)			22 (13, 34)	22 (13, 34)
		n			11 (5, 26)	8 (4, 21)			2 (1, 5)	4 (1, 6)			3 (1, 6)	3 (1, 5)			4 (2, 7)	3 (0, 8)
		post_p			0.24 (0.09, 0.39)	0.37 (0.16, 0.47)			0.39 (0.22, 0.46)	0.34 (0.24, 0.44)			0.39 (0.2, 0.47)	0.39 (0.2, 0.47)			0.41 (0.26, 0.47)	0.39 (0.24, 0.47)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.157 (0.112, 0.336)	0.137 (0.11, 0.435)			0.224 (0.126, 0.562)	0.206 (0.116, 0.351)			0.198 (0.112, 0.369)	0.177 (0.106, 1.014)			0.154 (0.112, 0.32)	0.179 (0.093, 0.435)
HRD+	ARSi	count					2	2	2	2					2	2	2	2
		time					24 (21, 28)	24 (21, 28)	24 (21, 28)	24 (21, 28)					24 (21, 28)	24 (21, 28)	24 (21, 28)	24 (21, 28)
		n					2 (0, 4)	0 (0, 1)	4 (3, 5)	3 (2, 4)					4 (3, 5)	4 (4, 5)	4 (3, 4)	6 (3, 10)
		post_p					0.43 (0.43, 0.43)	0.41 (0.41, 0.41)	0.45 (0.43, 0.48)	0.36 (0.25, 0.47)					0.26 (0.15, 0.38)	0.36 (0.29, 0.42)	0.31 (0.29, 0.33)	0.43 (0.37, 0.48)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.114 (0.114, 0.114)	0.099 (0.099, 0.099)	0.086 (0.061, 0.111)	0.169 (0.144, 0.195)					0.441 (0.333, 0.548)	0.14 (0.137, 0.142)	0.196 (0.195, 0.196)	0.16 (0.115, 0.204)
	Taxane_CT	count					39	39	39	39					39	39	39	39
		time					26 (18, 33)	26 (18, 33)	26 (18, 33)	26 (18, 33)					26 (18, 33)	26 (18, 33)	26 (18, 33)	26 (18, 33)
		n					7 (3, 15)	6 (2, 16)	3 (1, 5)	2 (1, 5)					5 (2, 7)	3 (1, 5)	3 (1, 5)	3 (0, 7)
		post_p					0.36 (0.18, 0.47)	0.32 (0.12, 0.45)	0.35 (0.22, 0.48)	0.36 (0.23, 0.45)					0.42 (0.23, 0.48)	0.36 (0.21, 0.46)	0.36 (0.23, 0.46)	0.36 (0.17, 0.49)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.134 (0.092, 0.243)	0.148 (0.093, 0.472)	0.228 (0.115, 0.816)	0.288 (0.147, 0.65)					0.161 (0.092, 0.275)	0.232 (0.131, 0.429)	0.219 (0.125, 0.816)	0.192 (0.113, 0.446)
	Platinum_CT	count					58	58	58	58					58	58	58	58
		time					20 (13, 32)	20 (13, 32)	20 (13, 32)	20 (13, 32)					20 (13, 32)	20 (13, 32)	20 (13, 32)	20 (13, 32)
		n					6 (4, 15)	6 (2, 11)	4 (1, 7)	4 (1, 7)					4 (2, 7)	3 (2, 6)	4 (1, 6)	3 (2, 5)
		post_p					0.35 (0.12, 0.47)	0.33 (0.15, 0.43)	0.4 (0.24, 0.48)	0.39 (0.26, 0.48)					0.43 (0.26, 0.49)	0.4 (0.23, 0.47)	0.39 (0.2, 0.47)	0.38 (0.27, 0.47)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.135 (0.093, 0.265)	0.155 (0.1, 0.407)	0.156 (0.104, 0.447)	0.142 (0.092, 0.432)					0.16 (0.083, 0.279)	0.177 (0.109, 0.447)	0.168 (0.102, 0.44)	0.153 (0.102, 0.366)
	PARPi	count					36	36	36	36					36	36	36	36
		time					21 (12, 31)	21 (12, 31)	21 (12, 31)	21 (12, 31)					21 (12, 31)	21 (12, 31)	21 (12, 31)	21 (12, 31)
		n					6 (4, 14)	6 (3, 16)	3 (2, 7)	4 (1, 7)					3 (1, 8)	4 (1, 6)	4 (1, 6)	3 (1, 8)
		post_p					0.3 (0.15, 0.42)	0.35 (0.14, 0.48)	0.37 (0.23, 0.49)	0.39 (0.23, 0.48)					0.36 (0.17, 0.46)	0.38 (0.26, 0.49)	0.4 (0.28, 0.48)	0.38 (0.21, 0.47)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.146 (0.091, 0.243)	0.13 (0.076, 0.286)	0.179 (0.092, 0.624)	0.183 (0.077, 0.462)					0.2 (0.1, 1.086)	0.173 (0.099, 0.485)	0.18 (0.126, 0.539)	0.178 (0.102, 0.607)
TEfus+	ARSi	count		6		6		6		6		6		6		6		6
		time		20 (12, 26)		20 (12, 26)		20 (12, 26)		20 (12, 26)		20 (12, 26)		20 (12, 26)		20 (12, 26)		20 (12, 26)
		n		4 (1, 6)		6 (2, 10)		2 (0, 6)		2 (0, 4)		3 (3, 8)		4 (2, 6)		4 (2, 4)		4 (2, 6)
		post_p		0.48 (0.42, 0.5)		0.34 (0.21, 0.44)		0.44 (0.34, 0.48)		0.39 (0.26, 0.41)		0.36 (0.19, 0.39)		0.37 (0.2, 0.47)		0.45 (0.34, 0.49)		0.42 (0.3, 0.49)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.089 (0.02, 0.11)		0.16 (0.131, 0.262)		0.13 (0.069, 0.176)		0.41 (0.14, 5.111)		0.2 (0.149, 0.493)		0.177 (0.122, 0.229)		0.173 (0.127, 0.23)		0.221 (0.081, 0.365)
	Taxane_CT	count		61		61		61		61		61		61		61		61
		time		21 (11, 34)		21 (11, 34)		21 (11, 34)		21 (11, 34)		21 (11, 34)		21 (11, 34)		21 (11, 34)		21 (11, 34)
		n		5 (2, 11)		11 (6, 23)		4 (1, 10)		2 (0, 7)		5 (2, 10)		5 (2, 8)		2 (1, 5)		2 (0, 7)
		post_p		0.3 (0.12, 0.48)		0.33 (0.17, 0.46)		0.36 (0.17, 0.48)		0.41 (0.22, 0.48)		0.39 (0.23, 0.48)		0.4 (0.24, 0.49)		0.39 (0.22, 0.48)		0.4 (0.25, 0.48)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0.144 (0.084, 0.266)		0.135 (0.108, 0.231)		0.155 (0.087, 0.388)		0.199 (0.116, 0.494)		0.152 (0.108, 0.364)		0.147 (0.105, 0.253)		0.229 (0.122, 0.634)		0.2 (0.118, 0.711)
	Platinum_CT	count		43		43		43		43		43		43		43		43
		time		24 (16, 33)		24 (16, 33)		24 (16, 33)		24 (16, 33)		24 (16, 33)		24 (16, 33)		24 (16, 33)		24 (16, 33)
		n		5 (2, 8)		8 (3, 22)		6 (2, 11)		3 (2, 8)		4 (1, 7)		3 (1, 7)		3 (1, 7)		4 (1, 7)
		post_p		0.31 (0.17, 0.44)		0.4 (0.19, 0.49)		0.3 (0.16, 0.47)		0.35 (0.18, 0.48)		0.34 (0.2, 0.47)		0.42 (0.23, 0.49)		0.34 (0.18, 0.48)		0.37 (0.25, 0.48)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.145 (0.108, 0.273)		0.138 (0.101, 0.373)		0.128 (0.086, 0.323)		0.185 (0.107, 0.373)		0.187 (0.122, 0.476)		0.159 (0.118, 0.372)		0.207 (0.12, 0.505)		0.172 (0.104, 0.579)
	PARPi	count		40		40		40		40		40		40		40		40
		time		26 (15, 34)		26 (15, 34)		26 (15, 34)		26 (15, 34)		26 (15, 34)		26 (15, 34)		26 (15, 34)		26 (15, 34)
		n		5 (1, 15)		7 (3, 21)		7 (4, 18)		4 (1, 8)		5 (1, 10)		4 (2, 8)		4 (1, 7)		5 (1, 8)
		post_p		0.33 (0.12, 0.47)		0.33 (0.17, 0.47)		0.27 (0.12, 0.43)		0.35 (0.2, 0.46)		0.4 (0.19, 0.49)		0.39 (0.22, 0.48)		0.38 (0.22, 0.48)		0.4 (0.26, 0.48)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.13 (0.079, 0.362)		0.152 (0.12, 0.276)		0.129 (0.084, 0.212)		0.185 (0.109, 0.491)		0.177 (0.101, 0.467)		0.157 (0.108, 1.154)		0.183 (0.108, 0.451)		0.163 (0.1, 0.654)